First-order derivative spectrophotometric estimation of nabumetone and paracetamol in tablet dosage form

Three new simple, economic spectrophotometric methods were developed and validated for the estimation of nabumetone in bulk and tablet dosage form. First method includes determination of nabumetone at absorption maxima 330 nm, second method applied was area under curve for analysis of nabumetone in the wavelength range of 326-334 nm and third method was First order derivative spectra with scaling factor 4. Beer law obeyed in the concentration range of 10-30 μg/mL for all three methods. The correlation coefficients were found to be 0.9997, 0.9998 and 0.9998 by absorption maxima, area under curve and first order derivative spectra. Results of analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for all three methods. The developed methods were also compared statistically using one way ANOVA. The proposed methods have been successfully applied for the estimation of nabumetone in bulk and pharmaceutical tablet dosage form.

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First-order derivative spectrophotometric estimation of gemifloxacin mesylate and ambroxol HCl in tablet dosage form

GSC Biological and Pharmaceutical Sciences ◽

10.30574/gscbps.2021.14.2.0034 ◽

2021 ◽

Vol 14 (2) ◽

pp. 029-036

Author(s):

Wrushali A. Panchale ◽

Ravindra L. Bakal

Keyword(s):

Dosage Form ◽

Correlation Coefficients ◽

Order Derivative ◽

Simultaneous Estimation ◽

Zero Crossing ◽

First Order ◽

Derivative Spectroscopy ◽

Ich Guidelines ◽

Tablet Dosage

Aim of present work was to develop and validate a simple, precise and accurate uv-vis spectrophotometric method for the simultaneous estimation of gemifloxacin mesylate (GEMI) and ambroxol HCl (AMB) in their combined tablet dosage form. The method is based on first-order derivative spectroscopy. For determination of sampling wavelengths, each of GEMI and AMB were scanned in the wavelength range of 200–400 nm in the spectrum mode and sampling wavelengths were selected at 360 nm (zero crossing of GEMI) where AMB showed considerable absorbance and at 221.6 nm (zero crossing of AMB) where GEMI showed considerable absorbance. The linearity was obtained in the concentration range of 32-192 µg/ml for GEMI and 7.5-45 µg/ml for AMB. The correlation coefficients were found to be 0.9987 and 0.9992 for GEMI and AMB, respectively. The method was validated as per ICH guidelines. Mean recoveries were found satisfactory. All the data of validation study was found to be satisfactorily. The proposed method can be applied for simultaneous estimation of both the drugs

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Development of New Analytical Method for Estimation of Lansoprazole in Bulk and Tablet dosage forms

International Journal of PharmTech Research ◽

10.20902/ijptr.2019.120409 ◽

2019 ◽

Vol 12 (4) ◽

pp. 63-69

Author(s):

S R Karajgi ◽

D T Mallikarjun ◽

M Somashekhar ◽

B Shivakumar

Keyword(s):

Analytical Method ◽

Dosage Form ◽

Spectroscopic Method ◽

Dosage Forms ◽

Spectroscopic Technique ◽

Order Derivative ◽

First Order ◽

Absorbance Maximum ◽

Ich Guidelines ◽

Tablet Dosage

The present paper reports a simple, accurate and precise spectroscopic technique for estimation of Lansoprazole by first order derivative technique in tablet dosage form. The spectroscopic method for estimation of Lansoprazole by first order derivative technique was carried out using methyl alcohol as solvent. The absorbance maximum was 275nm. Beers law observed in the range of 30 - 150μg/ml concentration. The recovery studies demonstrated the accuracy of the proposed procedure and the results were established as per ICH guidelines. The technique was used successfully for the estimation of Lansoprazole in bulk and tablet and pure dosage form.

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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION DICLOXACILLIN AND CEFDOXIME PROXETIL IN TABLET DOSAGE FORM

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v2i1.49 ◽

2012 ◽

Vol 2 (1) ◽

Author(s):

Drupad Rajnikant Acharya ◽

Dipti B Patel ◽

Vikram V Patel

Keyword(s):

Spectrophotometric Method ◽

Dosage Form ◽

Order Derivative ◽

Simultaneous Estimation ◽

First Order ◽

Development And Validation ◽

Tablet Dosage

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SIMULTANEOUS ESTIMATION OF EBASTINE AND MONTELUKAST SODIUM IN TABLET DOSAGE FORM BY UV-SPECTROPHOTOMETRY AND FIRST ORDER DERIVATIVE

INDIAN DRUGS ◽

10.53879/id.50.10.p0047 ◽

2013 ◽

Vol 50 (10) ◽

pp. 47-52

Author(s):

T. N Patil ◽

◽

S. D Firke ◽

S. B Bari ◽

N. S Joshi ◽

...

Keyword(s):

Dosage Form ◽

Order Derivative ◽

Simultaneous Estimation ◽

Uv Spectrophotometry ◽

Cross Point ◽

Zero Crossing ◽

First Order ◽

Montelukast Sodium ◽

The Mean ◽

Tablet Dosage

A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of ebastine and montelukast sodium by employing first order derivative zero crossing method in methanol and water. The first order derivative absorption at 234 nm (zero cross point of ebastine) was used for quantification of montelukast sodium and 281.60 nm (zero cross point of montelukast sodium) for quantification of ebastine. The linearity was established over the concentration range of 5-25 μg/mL for both ebastine and montelukast sodium with correlation coefficient r2 0.997 and 0.998, respectively. The mean % recoveries were found to be in the range of 102.8 – 103.2 % and 101 - 105 % for ebastine and montelukast sodium, respectively. The proposed method has been validated as per ICH guideline and successfully applied to the estimation of ebastine and montelukast sodium in their combined tablet dosage form.

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SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND INDAPAMIDE BY DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR COMBINED PHARMACEUTICAL DOSAGE FORM

INDIAN DRUGS ◽

10.53879/id.51.04.p0050 ◽

2014 ◽

Vol 51 (04) ◽

pp. 50-54

Author(s):

M. P Patel ◽

◽

M. R Patel ◽

R Hasumati ◽

M. N Noolvi ◽

...

Keyword(s):

Spectrophotometric Method ◽

Dosage Form ◽

Dual Wavelength ◽

Simultaneous Estimation ◽

Uv Spectrophotometry ◽

Amlodipine Besylate ◽

Pharmaceutical Dosage Form ◽

First Order ◽

Absorbance Difference ◽

Tablet Dosage

A simple, accurate, precise, rapid, economical UV spectrophotometry method, dual wavelength spectrophotometry, has been developed and validated for estimation of Indapamide (IND) and Amlodipine besylate (AML) in combined tablet dosage form and can be used in routine analysis. In this method, the absorbance at 360 nm and 256 nm of AML were same and no interference of IND at 360 nm. was observed. So, absorbance difference at 256-360 is used for estimation of IND and absorbance at 360 nm used for AML. The method was found to be linear in the concentration range of 3-18 μg/mL for IND (r2>0.99962) and 10-60 μg/mL for AML (r2>0.99969). Mean assay was found to be 99.32% and 101.34% for IND and AML respectively. In first order derivative spectrophotometry, the absorbance at 237.4 nm (ZCP of AML) and 241 nm (ZCP of IND) were used for estimation of IND and AML respectively. The method was found to be linear in the concentration range of 1.5-9 μg/mL for IND(r2=0.99983) and 5-30 μg/mL for AML(r2=0.99966). Mean assay was found to be 99.72% and 100.28% for IND and AML respectively.

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Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form

International Journal of Spectroscopy ◽

10.1155/2013/502310 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Kaminee Parmar ◽

Sunil Baldania ◽

Dimal Shah ◽

Usmangani Chhalotiya ◽

Naimin Parmar

Keyword(s):

Spectrophotometric Method ◽

Dosage Form ◽

Correlation Coefficients ◽

Order Derivative ◽

Simultaneous Estimation ◽

Pharmaceutical Dosage Form ◽

Zero Crossing ◽

Phenylephrine Hydrochloride ◽

First Order ◽

Crossing Point

A simple, precise, accurate, and economical spectrophotometric method has been developed for simultaneous estimation of levocetirizine dihydrochloride (LCT) and phenylephrine hydrochloride (PHE) by employing first-order derivative spectrophotometric method. The first-order derivative absorption at 240 nm (zero crossing point of PHE) was used for quantification of LCT and 283.2 nm (zero crossing point of LCT) for quantification of PHE. The linearity was established over the concentration range of 4–24 μg/mL and 8–48 μg/mL for LCT and PHE with correlation coefficients (r2) 0.9964 and 0.9972, respectively. The mean % recoveries were found to be in the range of 99.14%–100.43% for LCT and 98.73%–100.83% for PHE. The proposed method has been validated as per ICH guideline and successfully applied for the simultaneous estimation of LCT and PHE in combined tablet dosage form.

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