Biological activity screening of some hydrazone and chalcone derivatives

The intention of the present work is to quantify stigmasterol and β-sitosterol and simultaneously estimate them in the roots of Abroma augusta Linn. with the help of standard markers using HPTLC technique and to carry out the evaluation of their anti-arthritic and anti-gout activities. The fingerprinting of the methanolic extract was carried out and the individual markers were quantified by HPTLC. They were simultaneously estimated and the method was validated. The antiarthritic and antigout activities were evaluated. A system comprising of toluene: methanol (9:1% v/v) was selected for the determination of stigmasterol and β-sitosterol by HPTLC and detection was at 210nm after derivatization with anisaldehyde - sulphuric acid reagent. The methanolic extract of the plant showed good anti-arthritic and anti-gout activities. The present study is a forerunner for the development of newer herbal preparations for the treatment of arthritis and gout and also for the routine analysis of herbal constituents.

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Constituents and Biological Activities from Muehlenbeckia hastulata

Zeitschrift für Naturforschung C ◽

10.1515/znc-2002-9-1008 ◽

2002 ◽

Vol 57 (9-10) ◽

pp. 801-804 ◽

Cited By ~ 3

Author(s):

Silvia Erazo ◽

Orlando Muñoz ◽

Rubén García ◽

Igor Lemusa ◽

Nadine Backhousea ◽

...

Keyword(s):

Biological Activity ◽

Xanthine Oxidase ◽

Aerial Part ◽

Biological Activities ◽

Activity Screening ◽

Analgesic Activities

Muehlenbeckia hastulata (J. E.Sm.) Johnst. used mainly for its abortive properties was found active for oxytoxic and analgesic activities in a biological activity screening (oxytoxic, analgesic, antimicrobial, cytotoxic and xanthine oxidase assay). Epicatechin, emodin-8-glycoside and rutin were isolated from the aerial part and the root of the plant.

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Cytotoxicity Assay of 2,4-Dihydroxide-4’-Methoxychalcone Against Cervical (HeLa) Cancer Cell by MTT Assay

Biota ◽

10.20414/jb.v13i1.235 ◽

2020 ◽

Vol 13 (1) ◽

Author(s):

Novia Suryani ◽

Sabirin Matsjeh ◽

Mutmainah Mutmainah ◽

Daratu Eviana Kusuma Putri Eviana Kusuma Putri ◽

Damayanti Iskandar ◽

...

Keyword(s):

Cervical Cancer ◽

Biological Activity ◽

Hela Cell ◽

Cancer Cell ◽

Mtt Assay ◽

Antibacterial Activities ◽

Target Compound ◽

Chalcone Derivatives ◽

Chalcone Derivative ◽

Phenolic Group

Chalcone is one of the phenolic group secondary metabolic with numerous biological activity. Many studies have shown that chalcone derivatives compound has anticancer, anti-inflammatory, antimalarial, and antibacterial activities. The purpose of this research was to study the prediction potency unsaturated carbonyl system of chalcone derivative against the HeLa cell by MTT assay. Those activities assumed can inhibit the mechanism action of NF-kB that caused cervical cancer. The 2,4-dihydroxide-4’-methoxychalcone has done synthesis as a target compound by a sonochemical for 7 hours. The results showed that chalcone derivative most active against the HeLa cell.

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