Studies on Formulation and Evaluation of Eudragit RS PO Based Nanoparticulate System of Aceclofenac for Ocular Delivery

The Liqui-Mass technology (also known as Liqui-Pellet technology) has shown promising results in terms of enhancing the drug release rate of water insoluble drugs in a simplistic approach. However, there is no current study on sustained-release formulation using the Liqui-Mass technology. In this study, an attempt was made to produce a sustained-release Liqui-Tablet for the first time using a matrix-based approach. The non-volatile co-solvent used in the investigation included Tween 80, Tween 20 and Kolliphor EL. The production of sustained-release propranolol hydrochloride Liqui-Tablet was successful, and data from the saturation solubility test and dissolution test did not show much difference among the mentioned non-volatile co-solvent. The best Liqui-Tablet formulation took 24 h for drug release to reach at around 100%. There seemed to be a synergistic retarding drug release effect when a non-volatile co-solvent and Eudragit RS PO were used together. The increase of Eudragit RS PO concentration increased the retardant effect. Kinetic drug release analysis suggests that the best formulation followed the Higuchi model. The flowability of pre-compressed Liqui-Tablet pellets had no issues and its size distribution was narrow. Liqui-Tablet was generally robust and most formulations passed the friability test. The study revealed that Liqui-Mass technology can be employed to sustain drug release.

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In vitro Release Kinetic Study of Theophylline from Eudragit RS PO and Eudragit RL PO Matrix Tablets

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v8i1.5328 ◽

1970 ◽

Vol 8 (1) ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Apurba Sarker Apu ◽

Atiqul Haque Pathan ◽

Golam Kibria ◽

Reza-ul Jalil

Keyword(s):

Release Rate ◽

Release Kinetics ◽

Matrix Tablets ◽

Release Kinetic ◽

Matrix Tablet ◽

Eudragit Rs ◽

Zero Order Release ◽

Eudragit Rl ◽

Eudragit Rs Po

The aim of the present study was to investigate the release kinetics of theophylline from permeableacrylic polymer matrix tablets. Matrix tablets were prepared by direct compression method using Eudragit RS PO andEudragit RL PO. Two batches of matrix tablets were prepared. Only Eudragit RS PO was used in the first batch, andin the second batch both Eudragit RS PO and Eudragit RL PO were used as the rate retarding polymers in differentproportions. The variation of hardness was insignificant in batches. Drug release was investigated by using USPbasket method and the results of release rates were analyzed by using correlation coefficient value of Zero orderrelease plot & Higuchi plot and exponent value of Bi-exponential release profile. Theophylline tablets having onlyEudragit RS PO showed comparatively slow release but release rate improved significantly as seen in formulationscontaining Eudragit RL PO and Eudragit RS PO. It was also revealed that, in all cases the release of theophyllinefollowed mixed release kinetics where Zero order release kinetics was predominant.Key words: Sustained release; matrix tablet; theophylline; acrylic polymers; eudragit; release rate; dissolution;hardness.DOI: 10.3329/dujps.v8i1.5328Dhaka Univ. J. Pharm. Sci. 8(1): 1-6, 2009 (June)

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Effect of Hydrophobic Polymers on the Gastro Retention Time and In vitro Release of Ciprofloxacin HCl from Co-matrix Tablets

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v9i2.7893 ◽

1970 ◽

Vol 9 (2) ◽

pp. 97-102

Author(s):

Muhammad Shahidul Islam ◽

Kumar Bishwajit Sutradhar ◽

Jakir Ahmed Chowdhury ◽

Md Selim Reza

Keyword(s):

Adhesive Strength ◽

Retention Time ◽

Xanthan Gum ◽

Water Soluble ◽

Matrix Tablets ◽

Direct Compression ◽

Eudragit Rs ◽

Water Soluble Drug ◽

Eudragit Rs Po

The present study was conducted to investigate the effect of different polymers on the release profile and bio-adhesive strength of a water soluble drug, ciprofloxacin HCl from different percentages of Eudragit RS PO and Kollidon SR based co-matrix tablets. Matrix formulations were prepared by direct compression method. The bioadhesive property was investigated in terms of retention time following in vitro wash-off method. The concentrations of polymers were varied to investigate whether these variations can cause any change in release of ciprofloxacin HCl molecule and bio-adhesion property or not. In most of the cases it is found that Eudragit RS PO based co-matrix tablets release greater percentage of active drug and that bio-adhesive strength of Kollidon SR and xanthan gum based co-matrix tablets were significantly better. Finally it was revealed that xanthan gum provided optimum bioadhesion functioning as a synergist in co-matrices and comply the USP specification as a most suitable controlled release polymer. Key words: Gastro retention time; direct compression; ciprofloxacin HCl; Eudragit RS PO; Kollidon SR; xanthan gum. DOI: http://dx.doi.org/10.3329/dujps.v9i2.7893 Dhaka Univ. J. Pharm. Sci. 9(2): 97-102, 2010 (December)

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