Vascular Inflammation and Angiographic Severity of Coronary Artery Disease in Young Asian Indians

2014 ◽  
Vol 5 (1) ◽  
pp. 15-21
Author(s):  
Imran Ahmed ◽  
Achyut Sarkar ◽  
Arindam Pande ◽  
Naveen Chandra GS ◽  
Shailesh Patil ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Asian Indians ◽  
Vascular Inflammation ◽  
Artery Disease

scholarly journals Vascular inflammation and angiographic severity of coronary artery disease in young Asian Indians

2014 ◽  
Vol 66 ◽  
pp. S1
Author(s):  
Imran Ahmed ◽  
Achyut Sarkar ◽  
Arindam Pande ◽  
G.S. Naveen Chandra ◽  
Shailesh Patil ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Asian Indians ◽  
Vascular Inflammation ◽  
Artery Disease

scholarly journals Can vascular inflammation correlate to angiographic severity of coronary artery disease in young Asian Indians?

2015 ◽  
Vol 67 ◽  
pp. S48
Author(s):  
Imran Ahmed ◽  
Achyut Sarkar ◽  
Arnab Datta ◽  
Bhabani Chatterjee ◽  
Jayanta Saha ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Asian Indians ◽  
Vascular Inflammation ◽  
Artery Disease

scholarly journals A common variant in chromosome 9p21 associated with coronary artery disease in Asian Indians

2009 ◽  
Vol 88 (1) ◽  
pp. 113-118 ◽  
Author(s):  
Arindam Maitra ◽  
Debabrata Dash ◽  
Shibu John ◽  
Prathima R. Sannappa ◽  
Anupam P. Das ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Asian Indians ◽  
Common Variant ◽  
Chromosome 9P21 ◽  
Artery Disease

scholarly journals APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Shiwali Goyal ◽  
Yosuke Tanigawa ◽  
Weihua Zhang ◽  
Jin-Fang Chai ◽  
Marcio Almeida ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Genetic Variation ◽  
Coronary Artery ◽  
American Indians ◽  
Asian Indians ◽  
Small Subset ◽  
Serum Triglycerides ◽  
Artery Disease ◽  
Cad Risk

Abstract Background Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a lack of data in other Europeans and non-Europeans. Also, whether genetically increased plasma TG due to ApoC-III is causally associated with increased CAD risk is still unclear and inconsistent. The objectives of this study were to verify the cardioprotective role of earlier reported six LoF variants of APOC3 in South Asians and other multi-ethnic cohorts and to evaluate the causal association of TG raising common variants for increasing CAD risk. Methods We performed gene-centric and Mendelian randomization analyses and evaluated the role of genetic variation encompassing APOC3 for affecting circulating TG and the risk for developing CAD. Results One rare LoF variant (rs138326449) with a 37% reduction in TG was associated with lowered risk for CAD in Europeans (p = 0.007), but we could not confirm this association in Asian Indians (p = 0.641). Our data could not validate the cardioprotective role of other five LoF variants analysed. A common variant rs5128 in the APOC3 was strongly associated with elevated TG levels showing a p-value 2.8 × 10− 424. Measures of plasma ApoC-III in a small subset of Sikhs revealed a 37% increase in ApoC-III concentrations among homozygous mutant carriers than the wild-type carriers of rs5128. A genetically instrumented per 1SD increment of plasma TG level of 15 mg/dL would cause a mild increase (3%) in the risk for CAD (p = 0.042). Conclusions Our results highlight the challenges of inclusion of rare variant information in clinical risk assessment and the generalizability of implementation of ApoC-III inhibition for treating atherosclerotic disease. More studies would be needed to confirm whether genetically raised TG and ApoC-III concentrations would increase CAD risk.

scholarly journals Association of Interaction Between Smoking and CYP 2C19*3 Polymorphism With Coronary Artery Disease in a Uighur Population

2010 ◽  
Vol 16 (5) ◽  
pp. 579-583 ◽  
Author(s):  
Yi-Ning Yang ◽  
Xin-Lei Wang ◽  
Yi-Tong Ma ◽  
Xiang Xie ◽  
Zhen-Yan Fu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Vascular Inflammation ◽  
Multiple Logistic Regression Analysis ◽  
Rflp Analysis ◽  
Biologically Active ◽  
Pcr Rflp ◽  
Cyp2c19 Gene ◽  
Independent Risk Factors ◽  
Artery Disease

Objectives: Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which are potent endogenous vasodilators and inhibitors of vascular inflammation. The purpose of this study is to explore the relationship between the interaction of CYP2C19*3 polymorphism and smoking and coronary artery disease (CAD) in a Uighur population. Methods: In a Chinese Uighur case-control study of patients with CAD (n = 336) and healthy controls (n = 370), we investigated the roles of polymorphism in the CYP2C19 gene by the use of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The CYP2C19*3 AG + AA genotype was significantly more prevalent in patients with CAD (6.25.0% vs 2.96%; P = .03). Multiple logistic regression analysis showed 4 independent risk factors: the interaction of CYP2C19*3 and smoking (OR 7.22, 95% confidence interval [CI] 2.32-10.23; P = .009), smoking (OR 3.23, 95% CI 1.72-5.44; P = .003), blood sugar (OR 2.12, 95% CI 1.03-4.21; P < .01), and hypertension (OR 1.74, 95% CI 0.98-2.34; P = .013). Conclusions: The CYP2C19*3 polymorphism and CAD were synergistically and significantly associated in Chinese Uighur patients.

Sign in / Sign up

Export Citation Format

Share Document