scholarly journals Appraising the Clinical Efficacy of Herbal Topical Medications in the Treatment of Recurrent Aphthous Stomatitis - A Review

2021 ◽  
Vol 13 (4) ◽  
pp. 342-351
Author(s):  
Kavitha Muthu ◽  
Deepshika Saravanan ◽  
Saravanan Rethinam ◽  
Sathyasree Madeswaran ◽  
Nanditha Suresh
Keyword(s):  
Clinical Efficacy ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Topical Medications

scholarly journals CLINICAL EFFICACY AND SAFETY OF HERBAL MEDICINE THERAPY IN RECURRENT APHTHOUS STOMATITIS: A SYSTEMATIC REVIEW

2021 ◽  
pp. 14-20
Author(s):  
NOVIA TRI HASANAH ◽  
WAHYU HIDAYAT
Keyword(s):  
Systematic Review ◽  
Herbal Medicine ◽  
Adverse Effects ◽  
Pain Score ◽  
Clinical Efficacy ◽  
Biological Activities ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Efficacy And Safety ◽  
Ulcer Size

Recurrent aphthous stomatitis is the most common oral mucous ulcerative lesion with challenging treatment. Herbal medicine therapy can propose clinical efficacy and safety due to its large biological activities. The objective was to review the clinical efficacy and safety of herbal medicine therapy in terms of ulcer size, pain score, healing duration, and adverse effects in recurrent aphthous stomatitis. A systematic was conducted based on the PRISMA statement. The search was performed using four electronic databases, namely PubMed, Cochrane, Science Direct, and Google Scholar for articles published from 2016 until 2021 using specific keywords. The search was limited to randomized controlled trials (RCTs), in English, full text, and study in humans. The main outcome is expected to be ulcer size, pain score, healing duration, and adverse effects. Quality assessment of selected articles was conducted using the Quality Appraisal of Randomized Trials Checklist (Cochrane Risk of Bias tool). The methodology quality of studies was evaluated using the Cochrane Handbook for Systematic Review of Interventions and Rev Man software. Five articles were eligible for analysis. The population of the sample study ranged from 34-70 patients of 15-65 y old. The herbs used were Aloe vera (Aloe barbadensis Miller), curcumin (Curcuma longa), licorice (Glycyrrhiza glabra), tobacco (Nicotiana tabacum L.), and pomegranate (Punica granatum Linn.). This review showed that there is some evidence of the clinical efficacy and safety of herbal medicine therapy in improved outcomes of recurrent aphthous stomatitis treatment with minimum adverse effects.

scholarly journals Genetic and immunologic findings in children with recurrent aphthous stomatitis with systemic inflammation

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Martina Girardelli ◽  
Erica Valencic ◽  
Valentina Moressa ◽  
Roberta Margagliotta ◽  
Alessandra Tesser ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Systemic Inflammation ◽  
Lupus Erythematosus ◽  
Early Onset ◽  
Disease Onset ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Monogenic Disorders ◽  
Pathogenic Variants ◽  
Targeted Treatments

Abstract Background Recurrent aphthous stomatitis with systemic signs of inflammation can be encountered in inflammatory bowel disease, Behçet’s disease (BD), Systemic Lupus Erythematosus (SLE). In addition, it has been proposed that cases with very early onset in childhood can be underpinned by rare monogenic defects of immunity, which may require targeted treatments. Thus, subjects with early onset recurrent aphthous stomatitis receiving a clinical diagnosis of BD-like or SLE-like disease may deserve a further diagnostic workout, including immunologic and genetic investigations. Objective To investigate how an immunologic, genetic and transcriptomics assessment of interferon inflammation may improve diagnosis and care in children with recurrent aphthous stomatitis with systemic inflammation. Methods Subjects referred to the pediatric rheumatologist for recurrent aphthous stomatitis associated with signs of systemic inflammation from January 2015 to January 2020 were enrolled in the study and underwent analysis of peripheral lymphocyte subsets, sequencing of a 17-genes panel and measure of interferon score. Results We enrolled 15 subjects (12 females, median age at disease onset 4 years). The clinical diagnosis was BD in 8, incomplete BD in 5, BD/SLE overlap in 1, SLE in 1. Pathogenic genetic variants were detected in 3 patients, respectively 2 STAT1 gain of function variants in two patients classified as BD/SLE overlap and SLE, and 1 TNFAIP3 mutation (A20 haploinsufficiency) in patients with BD. Moreover 2 likely pathogenic variants were identified in DNASE1L3 and PTPN22, both in patients with incomplete BD. Interferon score was high in the two patients with STAT1 GOF mutations, in the patient with TNFAIP3 mutation, and in 3 genetic-negative subjects. In two patients, the treatment was modified based on genetic results. Conclusions Although recurrent aphthous stomatitis associated with systemic inflammation may lead to a clinical diagnosis of BD or SLE, subjects with early disease onset in childhood deserve genetic investigation for rare monogenic disorders. A wider genetic panel may help disclosing the genetic background in the subset of children with increased interferon score, who tested negative in this study.

Results of Double-Blind Placebo-Controlled Challenge with Nickel Salts in Patients Affected by Recurrent Aphthous Stomatitis

2003 ◽  
Vol 131 (4) ◽  
pp. 296-300 ◽  
Author(s):  
M.L. Pacor ◽  
G. Di Lorenzo ◽  
N. Martinelli ◽  
G. Lombardo ◽  
A. Di Gregoli ◽  
...  
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind ◽  
Double Blind Placebo
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