scholarly journals An Assessment of the Efficacy of Ofloxacin Brands on Clinical Isolates of Streptococcus Pneumoniae and Staphylococcus Aureus

2015 ◽  
Vol 9 (9) ◽  
Author(s):  
Eguono Esther Anomohanran ◽  
Ubreye Benjamin Owhe-Ureghe
2000 ◽  
Vol 44 (5) ◽  
pp. 1352-1355 ◽  
Author(s):  
Andrej Trampuz ◽  
Markus Wenk ◽  
Zarko Rajacic ◽  
Werner Zimmerli

ABSTRACT The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.


Author(s):  
B. Quintero ◽  
M. Araque ◽  
C. van der Gaast-de Jongh ◽  
F. Escalona ◽  
M. Correa ◽  
...  

1993 ◽  
Vol 7 (3) ◽  
pp. 125-132 ◽  
Author(s):  
Masaya Fukami ◽  
Tomas Norlander ◽  
Pontus Stierna ◽  
Karl Magnus Westrin ◽  
Bengt Carlsöö ◽  
...  

Unilateral maxillary sinusitis was experimentally induced in New Zealand White rabbits with Streptococcus pneumoniae serotype 3, Bacteroides fragilis NCTC 9343, and Staphylococcus aureus V8 in order to study possible differences in the inflammatory response of the sinus and nasal mucosa at different time-intervals during a 12-week period of infection. The initial sinus mucosal response, most pronounced in pneumococcal sinusitis, was characterized by leukocytosis, epithelial desquamation, and squamous cell metaplasia. Tissue reactions at later intervals included fibrosis of lamina propria, gland involution, polyp formation, and bone remodelling, and were most pronounced in S. aureus and B. fragilis sinusitis. The nasal mucosa was altered with a redistribution of goblet cells, development of polyps in the ethmoidal region, involution of Bowman's glands and locally, areas of degenerated olfactory sensory epithelium. These findings endorse that the degree of local pathology depends on the infecting microorganism's specific pathogenetic factors. However, local tissue factors guiding the cellular inflammatory proliferative and regenerative processes are also of fundamental importance for the type of pathological changes occurring in an infected nasal or sinus mucosa.


2015 ◽  
Vol 64 (4) ◽  
pp. 427-431 ◽  
Author(s):  
Susanna Esposito ◽  
Leonardo Terranova ◽  
Luca Ruggiero ◽  
Beatrice Ascolese ◽  
Valentina Montinaro ◽  
...  

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