Nasal colonization with Streptococcus pneumoniae and Staphylococcus aureus among hospitalized patients with laboratory-confirmed influenza

2018 ◽  
Vol 92 (2) ◽  
pp. 133-135
Author(s):  
Aaron Campigotto ◽  
Andrew E. Simor ◽  
Allison McGeer ◽  
Alexander Kiss ◽  
Samira Mubareka
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Hospitalized Patients ◽  
Nasal Colonization ◽  
And Staphylococcus Aureus

scholarly journals Pharmacokinetics and Pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in Human Skin Blister Fluid

2000 ◽  
Vol 44 (5) ◽  
pp. 1352-1355 ◽  
Author(s):  
Andrej Trampuz ◽  
Markus Wenk ◽  
Zarko Rajacic ◽  
Werner Zimmerli
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Oral Dose ◽  
Human Skin ◽  
Bactericidal Activity ◽  
Ex Vivo ◽  
Blister Fluid ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Skin Blister ◽  
And Staphylococcus Aureus

ABSTRACT The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.

Letters to the Editor

PEDIATRICS ◽  
1980 ◽  
Vol 66 (1) ◽  
pp. 154-155
Author(s):  
Charles M. Ginsburg ◽  
John D. Nelson
Keyword(s):  
Staphylococcus Aureus ◽  
Haemophilus Influenzae ◽  
Bacterial Pneumonia ◽  
Hospitalized Patients ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Letters To The Editor ◽  
And Staphylococcus Aureus

We do not disagree with the recommendations of Drs Fischer, Bass, and Arthur for treating hospitalized patients with pneumonia. They might have mentioned, additionally, the possible utility of cefamandole as an alternative to a penicillinase-resistant penicillin plus chloramphenicol for hospitalized infants with presumed bacterial pneumonia. We are currently evaluating cefuroxime, which has a similar in vitro spectrum, and are finding it effective in patients with pneumonia due to Haemophilus influenzae type b, pneumococci and Staphylococcus aureus.

scholarly journals Hydrogen Peroxide-Mediated Interference Competition by Streptococcus pneumoniae Has No Significant Effect on Staphylococcus aureus Nasal Colonization of Neonatal Rats

2008 ◽  
Vol 191 (2) ◽  
pp. 571-575 ◽  
Author(s):  
Elisa Margolis
Keyword(s):  
Hydrogen Peroxide ◽  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Interference Competition ◽  
Inhibitory Effect ◽  
Nasal Colonization ◽  
Neonatal Rats ◽  
Mixed Inoculum ◽  
Relative Scarcity

ABSTRACT It has been proposed that the relative scarcity of Staphylococcus aureus and Streptococcus pneumoniae cocolonization in the nasopharynxes of humans can be attributed to hydrogen peroxide-mediated interference competition. Previously it has been shown in vitro that H2O2 produced by S. pneumoniae is bactericidal to S. aureus. To ascertain whether H2O2 has this inhibitory effect in the nasal passages of neonatal rats, colonization experiments were performed with S. aureus and S. pneumoniae. The results of these experiments with neonatal rats are inconsistent with the hypothesis that hydrogen peroxide-mediated killing of S. aureus by S. pneumoniae is responsible for the relative scarcity of cocolonization by these bacteria. In mixed-inoculum colonization experiments and experiments where S. aureus invaded the nasopharynxes of rats with established S. pneumoniae populations, the density of S. aureus did not differ whether the S. pneumoniae strain was H2O2 secreting or non-H2O2 secreting (SpxB). Moreover, the advantage of catalase production by S. aureus in competition with a non-catalase-producing strain (KatA) during nasal colonization was no greater in the presence of H2O2-producing S. pneumoniae than in the presence of non-H2O2-producing S. pneumoniae.

scholarly journals Epidemiology of Streptococcus pneumoniae and Staphylococcus aureus colonization in healthy Venezuelan children

2010 ◽  
Vol 30 (1) ◽  
pp. 7-19 ◽  
Author(s):  
B. Quintero ◽  
M. Araque ◽  
C. van der Gaast-de Jongh ◽  
F. Escalona ◽  
M. Correa ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
And Staphylococcus Aureus

Mucosal Pathology of the Nose and Sinuses: A Study in Experimental Maxillary Sinusitis in Rabbits Induced by Streptococcus Pneumoniae, Bacteroides Fragilis, and Staphylococcus Aureus

1993 ◽  
Vol 7 (3) ◽  
pp. 125-132 ◽  
Author(s):  
Masaya Fukami ◽  
Tomas Norlander ◽  
Pontus Stierna ◽  
Karl Magnus Westrin ◽  
Bengt Carlsöö ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Nasal Mucosa ◽  
Maxillary Sinusitis ◽  
Bacteroides Fragilis ◽  
Sensory Epithelium ◽  
Squamous Cell Metaplasia ◽  
Tissue Factors ◽  
Tissue Reactions ◽  
And Staphylococcus Aureus

Unilateral maxillary sinusitis was experimentally induced in New Zealand White rabbits with Streptococcus pneumoniae serotype 3, Bacteroides fragilis NCTC 9343, and Staphylococcus aureus V8 in order to study possible differences in the inflammatory response of the sinus and nasal mucosa at different time-intervals during a 12-week period of infection. The initial sinus mucosal response, most pronounced in pneumococcal sinusitis, was characterized by leukocytosis, epithelial desquamation, and squamous cell metaplasia. Tissue reactions at later intervals included fibrosis of lamina propria, gland involution, polyp formation, and bone remodelling, and were most pronounced in S. aureus and B. fragilis sinusitis. The nasal mucosa was altered with a redistribution of goblet cells, development of polyps in the ethmoidal region, involution of Bowman's glands and locally, areas of degenerated olfactory sensory epithelium. These findings endorse that the degree of local pathology depends on the infecting microorganism's specific pathogenetic factors. However, local tissue factors guiding the cellular inflammatory proliferative and regenerative processes are also of fundamental importance for the type of pathological changes occurring in an infected nasal or sinus mucosa.

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