Ultrastructural And Light Microscopic Study To Determine The Potential Role Of Mast Cells In Pathogenesis Of Oral Lichen Planus.

Introduction. Oral lichen planus (OLP) is a chronic T cell mediated disease of oral mucosa, skin, and its appendages with a prevalence of 0.5 to 2.6% worldwide. Oral lichenoid reactions (OLR) are a group of lesions with diverse aetiologies but have clinical and histological features similar to OLP, thereby posing a great challenge in differentiating both lesions. Mast cells are multifunctional immune cells that play a major role in the pathogenesis of lichen planus by release of certain chemical mediators. Increased mast cell densities with significant percentage of degranulation have been observed as a consistent finding in pathogenesis of oral lichen planus. Aim. The current study was aimed at quantifying the mast cells in histopathological sections of OLP and OLR thereby aiding a means of distinguishing these lesions. Materials and Methods. The study group involved 21 cases of oral lichen planus, 21 cases of oral lichenoid reactions, and 10 control specimens of normal buccal mucosa. All the cases were stained with Toluidine Blue and routine haematoxylin and eosin and the mast cells were quantified. Statistical Analysis Used. The results were analyzed using the Kruskal–Wallis test and an intergroup analysis was performed using Mann–Whitney U test. Conclusion. The number of mast cells showed an increased value in oral lichen planus when compared to oral lichenoid reaction and thus an estimation of mast cells count could aid in distinguishing OLP from OLR histopathologically.

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Triggers of oral lichen planus flares and the potential role of trigger avoidance in disease management

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2017.05.508 ◽

2017 ◽

Vol 124 (3) ◽

pp. 248-252 ◽

Cited By ~ 7

Author(s):

Hannah X. Chen ◽

Rachel Blasiak ◽

Edwin Kim ◽

Ricardo Padilla ◽

Donna A. Culton

Keyword(s):

Disease Management ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Potential Role ◽

Oral Lichen

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Detection of microRNA expressions in tissues and exfoliative cells reveals the potential role of miR-203 in oral lichen planus

Journal of Chinese Pharmaceutical Sciences ◽

10.5246/jcps.2014.05.038 ◽

2014 ◽

Vol 23 (5) ◽

Author(s):

Zhendong Feng ◽

Demin Zhou

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Potential Role ◽

Oral Lichen

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Linear Oral Lichen Planus: A Rare Presentation

10.20944/preprints202006.0363.v1 ◽

2020 ◽

Author(s):

Prashanth Panta ◽

David Felix ◽

Dimitrios Andreadis ◽

Mukund Seshadri

Keyword(s):

Psychological Distress ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Potential Role ◽

Mechanical Trauma ◽

Low Grade ◽

Rare Presentation ◽

Koebner Phenomenon ◽

Oral Lichen

Mucosal irritation caused by cusps of upper and lower teeth represents a source of persistent, low grade mechanical trauma. This type of trauma can initiate and/or perpetuate oral lichen planus in a few susceptible patients. Here, we report a rare case of bilateral white linear striations in the buccal mucosa of a young patient, associated with sharp cusps. Oral lesions demonstrated a unique cuspal signature highlighting the causal role of subtle mucosal trauma in the genesis of reticular-oral lichen planus. Lesions appeared to be exacerbated by significant psychological distress experienced by the patient. Although the Koebner phenomenon is well reported in the cutaneous lichen planus literature, such presentations are relatively rare in the oral cavity. This report emphasizes the potential role of low-grade cuspal trauma/irritation in conjunction with psychological distress in the genesis of oral lichen planus.

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Role of apoptosis in erosive and reticular oral lichen planus exhibiting variable epithelial thickness

Brazilian Dental Journal ◽

10.1590/s0103-64402008000300001 ◽

2008 ◽

Vol 19 (3) ◽

pp. 179-185 ◽

Cited By ~ 21

Author(s):

Juliana M. Caldeira Brant ◽

Anilton C. Vasconcelos ◽

Luciana V. Rodrigues

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

Oral Lichen Planus ◽

Chronic Inflammatory Disease ◽

Mechanical Trauma ◽

Epithelial Thickness ◽

Healthy Mucosa ◽

Toxic Agents ◽

Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory disease with different clinical types. Reticular and erosive forms are the most common. Although the cause of OLP remains speculative, many findings suggest auto-immune involvement, mediated by T lymphocytes against the basal keratinocytes. Inflammation, mechanical trauma or toxic agents can affect the epithelial homeostasia. Increased apoptosis may cause a decrease in epithelial thickness reflecting in the activity of the lesion. The objective of this study was to evaluate the occurrence of apoptosis and epithelial thickness in reticular and erosive forms of OLP. 15 samples of OLP each type (reticular and erosive) plus 10 of healthy mucosa were collected and processed. After morphometry, the apoptotic index and epitelial thickness were obtained. TUNEL and M30 CytoDEATH immunohistochemical assay were used to validate the morphologic criteria used. Apoptosis in the erosive OLP was significantly more intense than in the reticular type and both forms of OLP presented more apoptosis than the healthy oral mucosa. Healthy oral mucosa was thicker than both OLP forms and thicker in OLP reticular form than in the erosive one. The clinical differences between reticular and erosive forms of OLP are related to variations in epithelial thickness and in intensity of apoptosis.

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Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis

Medicina ◽

10.3390/medicina55060257 ◽

2019 ◽

Vol 55 (6) ◽

pp. 257

Author(s):

Hamid Reza Mozaffari ◽

Maryam Molavi ◽

Pia Lopez-Jornet ◽

Masoud Sadeghi ◽

Mohsen Safaei ◽

...

Keyword(s):

Lichen Planus ◽

Interferon Gamma ◽

Oral Lichen Planus ◽

Meta Analysis ◽

Interleukin 4 ◽

Cochrane Library ◽

Pathological Effect ◽

Ifn Γ ◽

Oral Lichen

Background and Objectives: Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interleukin-4 ratio in the severity and development of OLP. Materials and Methods: The Scopus, Cochrane Library, PubMed, and Web of Science databases were systematically searched to retrieve the relevant studies published up from the database inception to March 2019. The crude mean difference (MD) and 95% confidence interval (CI) were calculated by RevMan 5.3 software using a random-effects model. A sensitivity analysis was performed on the results using the CMA 2.0 software. A total of 98 studies were retrieved from the databases, of which at last seven studies were included in this meta-analysis. Results: The findings showed that the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.22 (95% CI: −1.16, 0.72; p = 0.64) and 0.17 (95% CI: −1.50, 1.84; p = 0.84) in OLP patients compared to controls, respectively. In addition, the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.15 (95% CI: −0.53, 0.23; p = 0.43) and −0.39 (95% CI: −0.63, −0.15; p = 0.001) in patients with erythematous/ulcerative subtype compared to patients with reticular subtype, respectively. Conclusions: In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity.

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