scholarly journals On-chip sample preparations for Point-of-Care cellular analysis of blood

Author(s):  
Xichen Zhang ◽  
Leon Terstappen ◽  
Markus Beck
RSC Advances ◽  
2020 ◽  
Vol 10 (31) ◽  
pp. 18062-18072 ◽  
Author(s):  
Xichen Zhang ◽  
Dorothee Wasserberg ◽  
Christian Breukers ◽  
Bridgette J. Connell ◽  
Pauline J. Schipper ◽  
...  

Gellan/trehalose layers were tailored to optimize on-chip storage and release of antibodies in a simple point-of-care CD4 counting chip with excellent agreement with standard methods.


2018 ◽  
Vol 117 ◽  
pp. 659-668 ◽  
Author(s):  
Dorothee Wasserberg ◽  
Xichen Zhang ◽  
Christian Breukers ◽  
Bridgette J. Connell ◽  
Ellen Baeten ◽  
...  

Lab on a Chip ◽  
2018 ◽  
Vol 18 (3) ◽  
pp. 532-539 ◽  
Author(s):  
Dongyue Jiang ◽  
Seunguk Lee ◽  
Sung Woo Bae ◽  
Sung-Yong Park

We present a smartphone integrated optoelectrowetting (SiOEW) device as a low-cost, portable tool for on-chip sample preparation and microscopic detection of water quality.


2008 ◽  
Vol 94 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Marco Bianchessi ◽  
Sarah Burgarella ◽  
Marco Cereda

The development of new powerful applications and the improvement in fabrication techniques are promising an explosive growth in lab-on-chip use in the upcoming future. As the demand reaches significant levels, the semiconductor industry may enter in the field, bringing its capability to produce complex devices in large volumes, high quality and low cost. The lab-on-chip concept, when applied to medicine, leads to the point-of-care concept, where simple, compact and cheap instruments allow diagnostic assays to be performed quickly by untrained personnel directly at the patient's side. In this paper, some practical and economical considerations are made to support the advantages of point-of-care testing. A series of promising technologies developed by STMicroelectronics on lab-on-chips is also presented, mature enough to enter in the common medical practice. The possible use of these techniques for cancer research, diagnosis and treatment are illustrated together with the benefits offered by their implementation in point-of-care testing.


Lab on a Chip ◽  
2015 ◽  
Vol 15 (6) ◽  
pp. 1533-1544 ◽  
Author(s):  
John Nguyen ◽  
Yuan Wei ◽  
Yi Zheng ◽  
Chen Wang ◽  
Yu Sun

We present a monolithic microfluidic device capable of on-chip sample preparation for both RBC and WBC measurements from whole blood.


Lab on a Chip ◽  
2012 ◽  
Vol 12 (1) ◽  
pp. 167-173 ◽  
Author(s):  
Markus Beck ◽  
Silvia Brockhuis ◽  
Niels van der Velde ◽  
Christian Breukers ◽  
Jan Greve ◽  
...  

Nanophotonics ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 703-712 ◽  
Author(s):  
Daan Martens ◽  
Peter Bienstman

AbstractThe Mach-Zehnder interferometer (MZI) and the Vernier-cascade are highly responsive photonic sensors with large design freedom. They are therefore very suitable for interrogation through a broadband source and an on-chip spectral filter, a sensing scheme that is well equipped for point-of-care applications. In this work, the MZI is shown to outperform the Vernier-cascade through a better minimum detectable wavelength shift as well as a higher power efficiency, indicating its superiority in this sensing scheme. Fabricated MZIs yield bulk detection limits down to 8.8×10−7 refractive index units (RIU) in a point-of-care compatible measuring setup, indicating the potential of the proposed sensing scheme.


2015 ◽  
Vol 451 ◽  
pp. 240-246 ◽  
Author(s):  
Nicola Marziliano ◽  
Maria Francesca Notarangelo ◽  
Marco Cereda ◽  
Vittoria Caporale ◽  
Lucia Coppini ◽  
...  
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