Surgical Management of Multifocal Chondrosarcoma in Ollier Disease

2020 ◽  
Vol 22 (5) ◽  
pp. 373-382
Author(s):  
Daniel Kotrych ◽  
Jakub Pawlik ◽  
Radomir Czajka ◽  
Karina Szczypiór-Piasecka ◽  
Paweł Łęgosz ◽  
...  
Keyword(s):  
Histological Examination ◽  
Surgical Management ◽  
Well Being ◽  
Good Prognosis ◽  
Healthy Tissue ◽  
Congenital Disease ◽  
Orthopedic Department ◽  
Ollier Disease

Ollier disease is a rare congenital disease in which multiple enchondromas occur. The tumors can transform to malignant chondrosarcomas of various histologic grades. The patient we described has been treated in our orthopedic department six times, always being referred on account of new lesions. The tumors were excised with margins of healthy tissue. Each tumor was subjected to a histological examination to determine its type and grade. Chondroid tumors should be diagnosed carefully, because the treatment depends on their histologic features. If surgery is performed, removal of the tumor with a margin of healthy tissue is crucial for the patient’s well-being and good prognosis.

scholarly journals A Mobile App for Thyroid Cancer Patients Aiming to Enhance Their Quality of Life: Protocol for a Quasiexperimental Interventional Pilot Study

10.2196/13409 ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. e13409 ◽  
Author(s):  
Evanthia Giannoula ◽  
Ioannis Iakovou ◽  
Ioannis Katsikavelas ◽  
Panagiotis Antoniou ◽  
Vasilios Raftopoulos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Thyroid Cancer ◽  
Intervention Group ◽  
Well Being ◽  
Good Prognosis ◽  
Mobile App ◽  
Information Platform ◽  
Therapeutic Procedures ◽  
Eortc Qlq

Background Thyroid cancer (TC) is one of the fastest growing cancers all over the world. Differentiated thyroid cancer (DTC) is the most frequent subtype of TC. When appropriate treatment is given, the prognosis for the patient is generally excellent. Despite the generally good prognosis of thyroid carcinomas, the symptoms may range from emotional to physical discomfort, depending on the thyroid hormone status, which can severely affect the patient. Moreover, the diagnostic and therapeutic procedures that DTC patients have to undergo, such as thyroidectomy and radioiodine therapy, significantly affect their mental and physical well-being. Often, the physician only addresses the favorable prognosis of DTC compared with other cancer types and neglects to assess issues related to the quality of life (QoL) of the patient; this was the reason we decided to design a mobile app for DTC patients and their caregivers. Objective The aim of this study is to research the feasibility and applicability of an mHealth app tailored to DTC patients, as reflected in their QoL. The main features of the developed app offer access to useful information about thyroid cancer, diagnostic tests, and the appropriate therapy administered to DTC patients. Methods Based on the existing literature, we created an up-to-date information platform regarding TC and especially DTC. In order to develop an effective app that can be implemented in current health care, we designed a section where the patient and physician can keep a medical record in an effort to enable access to such information at any time. Finally, we designed a user-friendly notification program, including pill prescription, follow-up tests, and doctor visit reminders in order to equally facilitate the lives of the patient and physician. Results Having developed this mobile app, we aim to conduct a pilot quasiexperimental interventional trial. Our intention is to enroll at least 30 TC patients and assign them to intervention or control groups. Both groups will receive standard care for treating and monitoring TC, and the intervention group will also receive and use the DTC app. TC patients’ QoL will be assessed for both control and intervention groups in order to examine the effectiveness of the DTC app. QoL will be assessed through the QoL core questionnaire European Organisation for Research and Treatment of Cancer (EORTC) QLQ-THY34 in combination with the EORTC QLQ-C30 questionnaire through quantitative statistical analysis. Conclusions The use of mHealth apps can play a significant role in patient education, disease self-management, remote monitoring of patients, and QoL improvement. However, the main limitation of the majority of existing studies has been the lack of assessing their usefulness as well as the absence of specific instruments to carry out this assessment. In light of those considerations, we developed a mobile app tailored to the needs of DTC patients. Furthermore, we evaluated its contribution to the QoL of the patients by using the EORTC QLQ-THY34 questionnaire, an accurate and safe instrument for the evaluation of the QoL in TC patients, while supporting future planned endeavors in the field. International Registered Report Identifier (IRRID) PRR1-10.2196/13409

The Diagnosis and Surgical Management of Intracardiac Quill Foreign Body in a Dog

2016 ◽  
Vol 52 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Daniel Joseph Santiago Nucci ◽  
Julius Liptak
Keyword(s):  
Computed Tomography ◽  
Foreign Body ◽  
Right Ventricle ◽  
Surgical Management ◽  
Foreign Bodies ◽  
Cardiac Injury ◽  
Median Sternotomy ◽  
Good Prognosis ◽  
Bilateral Pneumothorax ◽  
The Right

A dog was referred to Alta Vista Animal Hospital with a porcupine quill penetrating the right ventricle. The presenting complaint was tachypnea and dyspnea secondary to bilateral pneumothorax. Computed tomography revealed bilateral pneumothorax without evidence of quills. A median sternotomy was performed and the quill was removed. The dog recovered uneventfully. Quill injuries are common in dogs; however, intracardiac quill migration is rare. Dogs without evidence of severe cardiac injury secondary to intracardiac foreign bodies may have a good prognosis.

scholarly journals Appendicular and Caecal Fecalith causing Perforation: A Case Report

2020 ◽  
Vol 58 (224) ◽  
Author(s):  
Rojan Adhikari ◽  
Prashant Simkhada ◽  
Deependra Mandal ◽  
Ashok Kunwar ◽  
Saroj Prasad Dhital
Keyword(s):  
Case Report ◽  
Acute Appendicitis ◽  
Histological Examination ◽  
Surgical Management ◽  
Conservative Management ◽  
Intestinal Tract ◽  
Inflammatory Lesion ◽  
Caecal Perforation

Fecalith is a concretion of dry compact feces or hard stony mass of faeces in the intestinal tract. Thoughappendicular fecoliths are commonly encountered, caecal fecoliths are rare entities. Fecoliths areamenable to conservative management with laxatives and enemas but surgical management preventsrecurrence. We present a case of 27 years old male who was diagnosed with acute appendicitis withperitonitis. He was intraoperatively diagnosed as gangrenous and perforated retrocaecal appendixwith multiple small fecaliths and a large fecalith on cecum with perforation. Appendectomy andprimary repair of caecal perforation done. Histological examination of perforated margin confirmedas an inflammatory lesion.

scholarly journals Consequences of transvaginal follicular puncture on well-being in cows

Reproduction ◽  
2003 ◽  
pp. 555-563 ◽  
Author(s):  
S Chastant-Maillard ◽  
H Quinton ◽  
J Lauffenburger ◽  
N Cordonnier-Lefort ◽  
C Richard ◽  
...  
Keyword(s):  
Histological Examination ◽  
Milk Production ◽  
Well Being ◽  
Holstein Cows ◽  
Control Group ◽  
Physiological Measurement ◽  
Cell Counts ◽  
Challenge Tests ◽  
Follicular Puncture ◽  
The Impact

The purpose of this study was to evaluate the impact of repeated follicular puncture used in the ovum pick-up technique on the welfare of cows. The evaluation relies on the physiological measurement of stress, milk production criteria, immune status, and the histological examination of ovaries. Two groups of five Holstein cows were submitted to epidural anaesthesia and genital palpation with insertion of an intravaginal ultrasound probe for transvaginal puncture (the puncture was not performed in the control group). Animals were manipulated twice a week for 8 weeks (16 manipulation sessions). The blood cortisol concentrations increased after each session; however, the concentrations were the same in both the control and the punctured groups. Two adrenocorticotrophic hormone challenge tests, performed before the first session and after the last session, showed an unchanged adrenal sensitivity through repeated puncture sessions. The transvaginal puncture did not affect milk production, or blood and milk somatic cell counts. Ovariectomies were performed on another group of four Holstein cows at various intervals (0 to 30 days) after five similar puncture sessions. Histological examination of the ovaries 4 days after puncture revealed blood-filled follicles and haemorrhagic foci in ovarian stroma, but the examination 30 days after the last puncture session demonstrated very limited, if any, fibrosis. On the basis of the criteria chosen for this study, repeated transvaginal follicular puncture on its own does not impact adversely on the welfare of cows.

scholarly journals Single-suture craniosynostosis and the epigenome: current evidence and a review of epigenetic principles

2021 ◽  
Vol 50 (4) ◽  
pp. E10
Author(s):  
Othman Bin Alamer ◽  
Adrian E. Jimenez ◽  
Tej D. Azad
Keyword(s):  
Environmental Factors ◽  
Clinical Research ◽  
Surgical Management ◽  
Genetic Predisposition ◽  
Current Evidence ◽  
Epigenetic Mechanisms ◽  
Congenital Disease ◽  
Single Suture ◽  
Shed Light

Craniosynostosis (CS) is a congenital disease that arises due to premature ossification of single or multiple sutures, which results in skull deformities. The surgical management of single-suture CS continues to evolve and is driven by a robust body of clinical research; however, the molecular underpinnings of CS remain poorly understood. Despite long-standing hypotheses regarding the interaction of genetic predisposition and environmental factors, formal investigation of the epigenetic underpinnings of CS has been limited. In an effort to catalyze further investigation into the epigenetic basis of CS, the authors review the fundamentals of epigenetics, discuss recent studies that shed light on this emerging field, and offer hypotheses regarding the role of epigenetic mechanisms in the development of single-suture CS.

Scintigraphy and SPECT/CT of Sentinel Lymph Nodes for Planning of Operative Intervention in Breast Cancer

2018 ◽  
pp. 50-59
Author(s):  
А. Рыжков ◽  
A. Ryzhkov ◽  
М. Билик ◽  
M. Bilik ◽  
А. Крылов ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Histological Examination ◽  
Surgical Management ◽  
Sentinel Nodes ◽  
Planar Scintigraphy ◽  
Regional Lymphadenectomy ◽  
Quality Of Surgery

Purpose: To increase the effectiveness and quality of surgery treatment for patients with early stages of breast cancer. Material and methods: Since 2016, 25 patients with breast cancer were examined and went through surgery. A lymphotropic colloidal radiopharmaceutical labeled with 99mTc was used; it was administered (150 MBq) the day before the operation. 20 patients received this injection intradermally into periareolar zone, 4 patients received it peritumourally (under control of ultrasound), 1 – paratumorally. Lymphoscintigraphy was performed 3 hours after injection, the images were acquired using dual-head gamma camera Symbia E (Siemens, Germany). A static multiplanar imaging (scintigraphy) (anterior, posterior, lateral projections) was performed for the sentinel nodes (SN) mapping. 25 planar examinations were performed. In 3 cases additional SPECT/CT study was performed using a hybrid SPECT/CT Symbia T2 (Siemens, Germany). Surgical intervention was done on the next day after scintigraphy. During the surgery the hand-held gamma probe NEO 2000 (Johnson & Johnson, USA) was used to localize radioactivity. The lymph nodes with the highest count (hot lymph nodes) were removed and sent for immediate histological examination. The results of immediate histological examination were evaluated again during next studies of gross specimen and slides. Results: During scintigraphy studies planar and SPECT/CT, 26 SN were detected in 20 women (80 %). In 15 patients only one SN lymph node was found, in 4 patients – 2, and in one case 3 SN were found. Intraoperative search of SN and immediate histological examination was conducted in 22 cases, 33 SN were found, while during planar scintigraphy only 26. In three cases, after histological examination (after obtaining examination results), patient surveillance was changed, these patients did not undergo through intraoperative radiometry and a decision was to conduct a one-stage mastectomy with regional lymphadenectomy. 10 out of 22 patients which underwent intraoperative radiometry and sentinel node biopsy, with immediate histological examination had metastases in the removed nodes, therefore lymphadenectomy had been performed. In the rest 12 patients after immediate histological examination of SN no evidence of tumor growth was found, thus lymphadenectomy was not performed. In case of three patients which did not undergo through intraoperative radiometry, lymphadenectomy was performed and after histological examination only two patients had tumor-involved SN, and one patient was clear. All intraoperative results were confirmed with next follow-up histological examinations. In 5 out of 25 patients (20 %) sentinel nodes were not founded. In these 5 cases during follow up period metastases were found in regional lymph nodes, and one patient had tumor emboli in lymphatic vessels, this considered being the cause of negative scintigraphy result. In 12 cases out of 25 (48 %) it was possible to minimize surgical management, and 13 (52 %) undergo lymphadenectomy. Conclusion: 1) The integration of SPECT/CT method of sentinel nodes search allows to plan an optimal surgical management, and can positively affect the long-term follow-up result of treatment of patients with breast cancer, and improve the quality of life. 2) The sensitivity and positive prognostic value (PPV) of planar scintigraphy and intraoperative radiometry of searching for SN are 80, 100 and 73.3, 100 %, respectively. 3) Thanks to the method of lymphoscintigraphy, 12 (48 %) of 25 women it was possible to minimize surgical management without lymphadenectomy.

scholarly journals Post COVID-19 invasive mucormycosis and actinomycosis co-infection: a case report

2021 ◽  
Author(s):  
Neha Mishra ◽  
Venkata Sai Shashank Mutya ◽  
Irfan Ibrahim K. ◽  
Girish Rai
Keyword(s):  
Case Report ◽  
Bone Tissue ◽  
Histological Examination ◽  
Surgical Management ◽  
Gold Standard ◽  
Bacterial Culture ◽  
Beta Lactams ◽  
Necrotic Bone ◽  
Sulfur Granules ◽  
Aggressive Debridement

<p>Actinomyces are commensals of human oropharynx and actinomycosis is considered mainly as an endogenous infection that is triggered by a mucosal lesion. Typically, the disease presents as a slowly progressive painless indurated mass evolving into multiple abscesses with draining sinus tracts sometimes expressing a typical yellow exudate with characteristic sulfur granules. The gold standard of diagnosis is histological examination and bacterial culture of the tissue. Most isolates are susceptible to beta lactams and they are the treatment of choice along with surgical management with drainage of abscesses and excision of recalcitrant fibrotic lesions and debridement of necrotic bone tissue. Here we present a case of 37-year-old male patient who has developed severe COVID-19 infection following which he developed invasive mucormycosis followed by actinomycosis. We postulate that the lymphopenia and the use of immunosuppressants used in treatment of COVID-19 lead to mucormycosis and aggressive debridement used as a strategy in treatment of mucormycosis led to colonization of actinomyces leading to cervicofacial actinomycosis.</p>

scholarly journals Safety of surgical management of accessory sinus pericranii in infants

2021 ◽  
pp. 103-107
Author(s):  
Mohamed M. Elsherbini ◽  
Hatem Badr ◽  
Amr Farid Khalil
Keyword(s):  
Surgical Management ◽  
Surgical Intervention ◽  
Good Prognosis ◽  
Pathological Process ◽  
Safe Procedure ◽  
Sinus Pericranii ◽  
Good Outcome

Purpose: to better understand the pathological process of sinus pericranii and the safety of the surgical intervention. Methods: patients’ archive review of patients who underwent surgical management for sinus pericranii with a confirmed diagnosis and with follow up period greater than 6 months. Results: 6 infants were included; all underwent disconnection surgically with good outcome in all cases. Conclusion: disconnection surgery for sinus pericranii is a safe procedure with a good prognosis.

scholarly journals A Mobile App for Thyroid Cancer Patients Aiming to Enhance Their Quality of Life: Protocol for a Quasiexperimental Interventional Pilot Study (Preprint)

2019 ◽  
Author(s):  
Evanthia Giannoula ◽  
Ioannis Iakovou ◽  
Ioannis Katsikavelas ◽  
Panagiotis Antoniou ◽  
Vasilios Raftopoulos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Thyroid Cancer ◽  
Intervention Group ◽  
Well Being ◽  
Good Prognosis ◽  
Mobile App ◽  
Information Platform ◽  
Therapeutic Procedures ◽  
Eortc Qlq

BACKGROUND Thyroid cancer (TC) is one of the fastest growing cancers all over the world. Differentiated thyroid cancer (DTC) is the most frequent subtype of TC. When appropriate treatment is given, the prognosis for the patient is generally excellent. Despite the generally good prognosis of thyroid carcinomas, the symptoms may range from emotional to physical discomfort, depending on the thyroid hormone status, which can severely affect the patient. Moreover, the diagnostic and therapeutic procedures that DTC patients have to undergo, such as thyroidectomy and radioiodine therapy, significantly affect their mental and physical well-being. Often, the physician only addresses the favorable prognosis of DTC compared with other cancer types and neglects to assess issues related to the quality of life (QoL) of the patient; this was the reason we decided to design a mobile app for DTC patients and their caregivers. OBJECTIVE The aim of this study is to research the feasibility and applicability of an mHealth app tailored to DTC patients, as reflected in their QoL. The main features of the developed app offer access to useful information about thyroid cancer, diagnostic tests, and the appropriate therapy administered to DTC patients. METHODS Based on the existing literature, we created an up-to-date information platform regarding TC and especially DTC. In order to develop an effective app that can be implemented in current health care, we designed a section where the patient and physician can keep a medical record in an effort to enable access to such information at any time. Finally, we designed a user-friendly notification program, including pill prescription, follow-up tests, and doctor visit reminders in order to equally facilitate the lives of the patient and physician. RESULTS Having developed this mobile app, we aim to conduct a pilot quasiexperimental interventional trial. Our intention is to enroll at least 30 TC patients and assign them to intervention or control groups. Both groups will receive standard care for treating and monitoring TC, and the intervention group will also receive and use the DTC app. TC patients’ QoL will be assessed for both control and intervention groups in order to examine the effectiveness of the DTC app. QoL will be assessed through the QoL core questionnaire European Organisation for Research and Treatment of Cancer (EORTC) QLQ-THY34 in combination with the EORTC QLQ-C30 questionnaire through quantitative statistical analysis. CONCLUSIONS The use of mHealth apps can play a significant role in patient education, disease self-management, remote monitoring of patients, and QoL improvement. However, the main limitation of the majority of existing studies has been the lack of assessing their usefulness as well as the absence of specific instruments to carry out this assessment. In light of those considerations, we developed a mobile app tailored to the needs of DTC patients. Furthermore, we evaluated its contribution to the QoL of the patients by using the EORTC QLQ-THY34 questionnaire, an accurate and safe instrument for the evaluation of the QoL in TC patients, while supporting future planned endeavors in the field. INTERNATIONAL REGISTERED REPORT PRR1-10.2196/13409

Cecal Endometriosis With Intestinal Metaplasia Misdiagnosed as Neoplasm of the Cecum by Intraoperative Histological Examination

2017 ◽  
Vol 26 (1) ◽  
pp. 24-30
Author(s):  
Xinge Fu ◽  
Juhong Jiang ◽  
Bin Li ◽  
Xiao-ying Tian ◽  
Zhi Li
Keyword(s):  
Intestinal Metaplasia ◽  
Histological Examination ◽  
Surgical Management ◽  
Pseudomyxoma Peritonei ◽  
Histological Diagnosis ◽  
Cytological Atypia ◽  
Precise Diagnosis ◽  
Mucinous Epithelium ◽  
Microscopic Inspection

Appendiceal or cecal endometriosis with intestinal metaplasia is uncommon and may mimic mucinous tumors of the appendix. A 50-year-old woman was found incidentally to have an ileocecal lesion. In the intraoperative histological examination, a diagnosis of neoplasm of the cecum was made predominantly based on mucin extrusion with scattered lining mucinous epithelium. However, postoperative histological diagnosis of the lesion was cecal endometriosis with intestinal metaplasia as determined by thoroughly microscopic inspection and the presence of typical endometrial glands with surrounding endometrial-type stroma. There was no evidence of recurrence and pseudomyxoma peritonei after 1 year of follow-up. Overinterpretation of cytological atypia or mucin extrusion in endometriosis may lead to inappropriate surgical management. Therefore, in any ileocecal or appendiceal lesions with mucinous epithelia and mucin extrusions, removal of sufficient tissue from different portions of the lesion is essential for surgeons and pathologists to make a precise diagnosis in the intraoperative histological examination.

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