scholarly journals Prevalence of Polyoma BK Virus (BKPyV) , Epstein-Barr Virus (EBV) and Human Papilloma Virus (HPV) in Oropharyngeal Cancer

2015 ◽  
Vol 64 (4) ◽  
pp. 323-328 ◽  
Author(s):  
Dorota Polz-Gruszka ◽  
Kamal Morshed ◽  
Adrian Jarzyński ◽  
Małgorzata Polz-Dacewicz
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Oropharyngeal Cancer ◽  
Epstein Barr Virus ◽  
Bk Virus ◽  
Papilloma Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
Pre Treatment ◽  
Paraffin Tissue

The aim of this study was to analyze the prevalence of BK virus, Human Papillomavirus and Epstein-Barr virus in oropharyngeal cancer, and to test our hypothesis that BKV/HPV/EBV co-infection plays a role in oropharyngeal squamous cell carcinoma. The correlation between viral infection, OSCC, anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. The examination samples were collected from 62 patients from paraffin tissue blocks. Males (90.3%) with, smoking (83.9%) and alcohol abuse (67.7%) problems prevailed in the studied group. G2 histological type was recognized in 80.6% cases. T4 (77.4%) and N2 (56.5%) traits occurred in the majority of patients. No cases of metastasis were observed (M0 100%). HPV – 24.2%, EBV – 27.4% and BKV 17.7% were detected in the studied samples. We observed co-infection EBV/BKV in 8% of cases, HPV/BKV in 4.8%, and HPV/EBV in 9% cases. Only in two cases co-infection of all three viruses was found.

scholarly journals Coinfection with Epstein–Barr Virus (EBV), Human Papilloma Virus (HPV) and Polyoma BK Virus (BKPyV) in Laryngeal, Oropharyngeal and Oral Cavity Cancer

2017 ◽  
Vol 18 (12) ◽  
pp. 2752 ◽  
Author(s):  
Bartłomiej Drop ◽  
Małgorzata Strycharz-Dudziak ◽  
Ewa Kliszczewska ◽  
Małgorzata Polz-Dacewicz
Keyword(s):  
Oral Cavity ◽  
Human Papilloma Virus ◽  
Epstein Barr Virus ◽  
Oral Cavity Cancer ◽  
Bk Virus ◽  
Papilloma Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5834 ◽  
Author(s):  
Jose Manuel Vazquez-Guillen ◽  
Gerardo C. Palacios-Saucedo ◽  
Lydia Guadalupe Rivera-Morales ◽  
Monica Valeria Alonzo-Morado ◽  
Saira Berenice Burciaga-Bernal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epstein Barr Virus ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
Barr Virus ◽  
Hpv Genotypes ◽  
Epstein Barr

Background Human papillomavirus (HPV) is recognized as an important risk factor for laryngeal carcinogenesis. Although HPV-16 and 18 have been strongly implicated, the presence of other high-risk HPV (HR-HPV) genotypes or the coinfection with Epstein-Barr virus (EBV) or Merkel cell polyomavirus (MCPV) may increase the risk, but their etiological association has not been definitively established. Methods We characterized the genotype-specific HPV and the frequency of EBV and MCPV infections through the detection of their DNA in 195 laryngeal specimens of squamous cell carcinoma (SCC) histologically confirmed. Results HPV DNA was detected in 93 (47.7%) specimens. HPV-11 was the most frequent with 68 cases (73.1%), and HPV-52 was the most frequently HR-HPV found with 51 cases, which corresponds to 54.8% of all HPV-positive specimens. EBV DNA was detected in 54 (27.7%) tumor tissue specimens of which 25 (46.3%) were in coinfection with HPV. MCPV DNA was detected only in 11 (5.6%) cases of which 5 (45.4%) were in coinfection with an HR-HPV. No association between the presence of DNA of the three examined viruses and the patient smoking habits, alcohol consumption, age, the keratinization status, differentiation grade, or localization of the tumor in the larynx were found. Discussion HPV-52 was the most prevalent HR-HPV, which may suggest that this and other genotypes in addition to HPV-16 and 18 could be considered for prophylaxis. However, further studies including non-cancer larynx cases and the evaluation of other molecular markers and viral co-infection mechanisms are needed to determine the role of the different HR-HPV genotypes, EBV, and MCPV in the etiology of SCC of the larynx.

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