scholarly journals Correlation between Alteration of Sharp-wave Ripple Coupled Cortical Oscillation and Long-term Memory Deficit in Alzheimer Disease Model Mice

2021 ◽  
Vol 30 (6) ◽  
pp. 430-440
Author(s):  
Hyunwoo Yang ◽  
Yong Jeong
Keyword(s):  
Alzheimer Disease ◽  
Disease Model ◽  
Memory Deficit ◽  
Long Term Memory ◽  
Term Memory ◽  
Sharp Wave

scholarly journals Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3

2021 ◽  
Author(s):  
Andras Ecker ◽  
Bence Bagi ◽  
Eszter Vertes ◽  
Orsolya Steinbach-Nemeth ◽  
Maria Rita Karlocai ◽  
...  
Keyword(s):  
Place Cells ◽  
Data Driven ◽  
Long Term Memory ◽  
Term Memory ◽  
Cellular Adaptation ◽  
Sharp Wave ◽  
Synaptic Interactions ◽  
Area Ca3 ◽  
Reversed Order

Hippocampal place cells are activated sequentially as an animal explores its environment. These activity sequences are internally recreated ("replayed"), either in the same or reversed order, during bursts of activity (sharp wave-ripples; SWRs) that occur in sleep and awake rest. SWR-associated replay is thought to be critical for the creation and maintenance of long-term memory. We sought to identify the cellular and network mechanisms of SWRs and replay by constructing and simulating a data-driven model of area CA3 of the hippocampus. Our results show that the structure of recurrent excitatory interactions established during learning not only determines the content of replay, but is essential for the generation of the SWRs as well. We find that bidirectional replay requires the interplay of the experimentally confirmed, temporally symmetric plasticity rule, and cellular adaptation. Our model provides a unifying framework for diverse phenomena involving hippocampal plasticity, representations, and dynamics.

136 EFFECTS OF ETHANOL ADMINISTRATION ON LONG-TERM MEMORY DEFICIT INDUCED BY PARTIAL CHRONIC SLEEP DEPRIVATION IN MICE

2009 ◽  
Vol 10 ◽  
pp. S37
Author(s):  
L. Sanday ◽  
C.L. Patti ◽  
S.R. Kameda ◽  
M.L. Andersen ◽  
S. Tufik ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Memory Deficit ◽  
Ethanol Administration ◽  
Long Term Memory ◽  
Term Memory ◽  
Chronic Sleep Deprivation ◽  
Chronic Sleep

scholarly journals Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease

2018 ◽  
Author(s):  
Dongzhi Ran ◽  
Baogang Xie ◽  
Zongjie Gan ◽  
Xicui Sun ◽  
Huaiyu Gu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Memory Deficit ◽  
Long Term Memory ◽  
Term Memory ◽  
Drosophila Model

scholarly journals Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Przemyslaw Jarzebowski ◽  
Clara S Tang ◽  
Ole Paulsen ◽  
Y Audrey Hay
Keyword(s):  
Cholinergic Neurons ◽  
Memory Formation ◽  
Long Term Memory ◽  
Term Memory ◽  
Goal Location ◽  
Optogenetic Stimulation ◽  
Sharp Wave ◽  
Network States ◽  
Stimulation Of

The hippocampus plays a central role in long-term memory formation, and different hippocampal network states are thought to have different functions in this process. These network states are controlled by neuromodulatory inputs, including the cholinergic input from the medial septum. Here, we used optogenetic stimulation of septal cholinergic neurons to understand how cholinergic activity affects different stages of spatial memory formation in a reward-based navigation task in mice. We found that optogenetic stimulation of septal cholinergic neurons (1) impaired memory formation when activated at goal location but not during navigation; (2) reduced sharp wave-ripple (SWR) incidence at goal location; and (3) reduced SWR incidence and enhanced theta-gamma oscillations during sleep. These results underscore the importance of appropriate timing of cholinergic input in long-term memory formation, which might help explain the limited success of cholinesterase inhibitor drugs in treating memory impairment in Alzheimer's disease.

scholarly journals Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

2020 ◽  
Author(s):  
Przemyslaw Jarzebowski ◽  
Clara S Tang ◽  
Ole Paulsen ◽  
Y. Audrey Hay
Keyword(s):  
Cholinergic Neurons ◽  
Memory Formation ◽  
Long Term Memory ◽  
Term Memory ◽  
Goal Location ◽  
Optogenetic Stimulation ◽  
Sharp Wave ◽  
Network States ◽  
Stimulation Of

The hippocampus plays a central role in long-term memory formation, and different hippocampal network states are thought to have different functions in this process. These network states are controlled by neuromodulatory inputs, including the cholinergic input from the medial septum. Here, we used optogenetic stimulation of septal cholinergic neurons to understand how cholinergic activity affects different stages of spatial memory formation in a reward-based navigation task in mice. We found that optogenetic stimulation of septal cholinergic neurons (1) impaired memory formation when activated at goal location but not during navigation; (2) reduced sharp wave-ripple (SWR) incidence at goal location; and (3) reduced SWR incidence and enhanced theta-gamma oscillations during sleep. These results underscore the importance of appropriate timing of cholinergic input in long-term memory formation, which might help explain the limited success of cholinesterase inhibitor drugs in treating memory impairment in Alzheimer's disease.

scholarly journals Structural Anatomical Investigation of Long-Term Memory Deficit in Behavioral Frontotemporal Dementia

2018 ◽  
Vol 62 (4) ◽  
pp. 1887-1900 ◽  
Author(s):  
Maxime Bertoux ◽  
Emma C. Flanagan ◽  
Matthew Hobbs ◽  
Amparo Ruiz-Tagle ◽  
Carolina Delgado ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Memory Deficit ◽  
Long Term Memory ◽  
Term Memory

Short-term and long-term memory deficit following intracarotid Amytal injection: Further support for the memory consolidation hypothesis

1989 ◽  
Vol 11 (2) ◽  
pp. 167-185 ◽  
Author(s):  
Isabelle Rouleau ◽  
Raymonde Labrecque ◽  
Jean-Marc Saint-Hilaire ◽  
Bruno Cardu ◽  
Normand Giard
Keyword(s):  
Memory Consolidation ◽  
Memory Deficit ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory

scholarly journals A Verbal Long Term Memory Deficit in Frontal Lobe Damaged Patients

Cortex ◽  
1986 ◽  
Vol 22 (2) ◽  
pp. 229-242 ◽  
Author(s):  
Wolfgang Jetter ◽  
Ulrich Poser ◽  
Robert B. Freeman ◽  
Hans J. Markowitsch
Keyword(s):  
Frontal Lobe ◽  
Memory Deficit ◽  
Long Term Memory ◽  
Term Memory
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