Factors Affecting the Dose of Cisplatin in Concurrent Chemoradiotherapy with High-Dose Cisplatin for Head and Neck Cancer

2021 ◽  
Vol 114 (2) ◽  
pp. 159-166
Author(s):  
Ryosuke Kitoh ◽  
Yoh-ichiro Iwasa ◽  
Kentaro Mori
2021 ◽  
Author(s):  
Hundo Cho ◽  
Seok Yun Kang ◽  
Hyun Woo Lee ◽  
Yong Won Choi ◽  
Tae-Hwan Kim ◽  
...  

Abstract Background The risk of thromboembolic events (TEE) in cancer patients, especially those receiving cisplatin-based chemotherapy, is higher than that of general population. Methods The study investigated the incidence of TEE in 257 head and neck (H&N) cancer patients, during or within 6 months of completion of concurrent chemoradiotherapy (CCRT) with cisplatin, and analyzed factors affecting TEE occurrence. Results TEE occurred in 5 patients, an incidence rate of 1.9%. Khorana score was the only factor associated with TEE occurrence (p = 0.010). Conclusions The incidence of TEE in H&N cancer patients who underwent CCRT with cisplatin was relatively low when compared to other types of cancer. However, patients with a high Khorana score require more careful surveillance for possible TEE occurrence.


Author(s):  
Kenneth R. Stevens ◽  
Amy Britsch ◽  
William T. Moss

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