scholarly journals An Investigation of the Use of a Metered-Dose Inhaler(MDI) in Patients with Bronchial Asthma and the Pharmaceutical Instructions.

1999 ◽  
Vol 25 (1) ◽  
pp. 65-68
Author(s):  
YOSHIKO YAHATA ◽  
NORIKO YOKOZAWA ◽  
AIKO OSAWA ◽  
TOMOHIRO KAWADA ◽  
YOSHITAKA KURASAWA ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Metered Dose

scholarly journals STUDY OF EFFICACY OF METERED DOSE INHALER (MDI) AND DRY POWDER INHALER (DPI) FOR DELIVERY OF SALBUTAMOL IN TREATMENT OF ACUTE EXACERBATION OF ASTHMA IN PATIENTS, ATTENDING IN TERTIARY CARE HOSPITAL AT, PATNA

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Ajit Kumar ◽  
Raj Narayan Seth
Keyword(s):  
Acute Exacerbation ◽  
Bronchial Asthma ◽  
Tertiary Care ◽  
Dry Powder Inhaler ◽  
Dose Inhaler ◽  
Care Hospital ◽  
Metered Dose Inhaler ◽  
Dry Powder ◽  
Accessory Muscle ◽  
Metered Dose

Objective: Present study was undertaken to compare the efficacy of Metered dose inhaler (MDI) with spacer and with Dry powder inhaler (DPI) for delivery of salbutamol in acute exacerbation of bronchial asthma. It is a randomized controlled trial study. Material and Methods: A total of 78 children in the age group of 6-14 years who presented with a mild or moderate acute exacerbation of asthma were included in the study. Salbutamol dose of 400µg were given to all the children’s by either a MDI with spacer or a DPI in randomized pattern. All the changes in the wheezing and accessory muscle scores, Sa02, and PEFR were noted. Results: Out of 78 children, 42 were assigned to the MDI spacer group and 36 to rotahaler (DPI) group. After receiving treatment, the PEFR improved by about 14% in both the groups. The oxygen saturation increased by 2.1% in both the groups. Within each group, the improvement in PEFR, Sa02, wheeze and accessory muscle score after the treatment was statistically significant. Conclusion: Metered dose inhaler with spacer and Dry powder inhaler are equally effective in delivering salbutamol in therapy of mild to moderate acute exacerbations of bronchial asthma in children between 6-14 years of age Keyword: DPI, Salbutamol, Treatment, Asthma, Children, MDI, PEFR

scholarly journals A COMPARATIVE STUDY OF METERED DOSE INHALER WITH SPACER AND DRY POWDER INHALER FOR DELIVERY OF SALBUTAMOL IN ACUTE EXACERBATIONS OF BRONCHIAL ASTHMA

2021 ◽  
pp. 25-26
Author(s):  
Rakesh Kumar
Keyword(s):  
Acute Exacerbation ◽  
Bronchial Asthma ◽  
Statistical Tests ◽  
Dry Powder Inhaler ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Dry Powder ◽  
Accessory Muscle ◽  
Acute Exacerbations ◽  
Metered Dose

Objective: To compare the efficacy of metered dose inhaler with spacer with dry powder inhaler for delivery of salbutamol in acute exacerbation of bronchial asthma Design:Randomized controlled trial in the Setting of Department of Pediatrics, Patna Medical College and Hospital Patna Methods: Children in the age group of 5 - 12 years who presented with a mild or moderate acute exacerbation of asthma were randomized to receive 400 mcg salbutamol by either a MDI with spacer or a DPI. The changes in the wheezing and accessory muscle scores, SaO2, and PEFR were recorded and subjected to statistical tests for significance. Results: Two hundred and fifty-three children were studied; 128 were assigned to the MDI-spacer group and 125 to rotahaler (DPI) group. After receiving treatment, the PEFR improved by about 11% in both the groups. The oxygen saturation increased by 2% in both the groups.Within each group, the improvement in PETR, SaO2, wheeze and accessory muscle score after the treatment was statistically significant. Conclusion: Metered dose inhaler with spacer and dry powder inhaler are equally effective in delivering salbutamol in therapy of mild to moderate acute exacerbations of bronchial asthma in children between 5-12 years of age.

scholarly journals The comparison the efficacy of budesonide by nebulizer, metered dose inhaler and dry powder inhaler in chronic stable bronchial asthma

2018 ◽  
Vol 7 (7) ◽  
pp. 1333
Author(s):  
Dilshad Ali Rizvi ◽  
Afroz Abidi ◽  
Abhishek Agarwal ◽  
Ali Ahmad
Keyword(s):  
Pulmonary Function ◽  
Bronchial Asthma ◽  
Vital Capacity ◽  
Dry Powder Inhaler ◽  
Forced Expiratory Volume ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Dry Powder ◽  
Function Test ◽  
Metered Dose

Background: The study has been performed to evaluate the efficacy of budesonide delivery by different form of devices like nebulizer, metered dose inhaler and dry powder inhaler to adult patients of chronic stable bronchial asthma. The changes in pulmonary function test parameters have been consider for evaluation.Methods: This prospective study was undertaken to assess the relative efficiency of budesonide administered from devices like nebulizer, metered dose inhaler and dry powder inhaler in adult patients of chronic stable bronchial asthma. Fifty subjects where administered budesonide (1mg) via nebulizer, budesonide (400 microgram) by metered dose inhaler and dry powder inhaler consecutively each week for four weeks under direct supervision. To analyze the effect of budesonide delivered through different devices pulmonary function test was carried out on the subject before and one hour after administration of the drug on each visit.Results: No significant difference in Peak expiratory flow rate (P=0.77), forced expiratory volume in one second (P=0.851), forced vital capacity (P=0.178) and forced expiratory volume in one second and forced vital capacity ratio (P=0.298) was seen after giving budesonide by different devices.Conclusions: Budesonide delivered by different devices (nebulizer, metered dose inhaler, and dry powder inhaler) have similar effect on lung function in patients of chronic stable bronchial asthma. In the daily clinical practice, the correct choice of an inhaler device should be related with the patient's characteristics. They may be used interchangeably depending on availability, cost and compliance of the patients.

scholarly journals Comparison of clinical efficacy of nebulised salbutamol and salbutamol metered dose inhaler in children with mild or moderate exacerbation of bronchial asthma

2017 ◽  
Vol 4 (3) ◽  
pp. 741
Author(s):  
Jose O. ◽  
Sunil Daniel ◽  
Minu Krishnan
Keyword(s):  
Bronchial Asthma ◽  
Clinical Efficacy ◽  
Dose Inhaler ◽  
P Value ◽  
Metered Dose Inhaler ◽  
Medical College ◽  
Need For Power ◽  
Nebulised Salbutamol ◽  
Industrialized Nations ◽  
Metered Dose

Background: Bronchial asthma is the commonest chronic disease in industrialized nations. Aerosol therapy has revolutionized the treatment of bronchial asthma in children as in adults. Even though nebulisation is a simple technique, it is expensive and there is a need for power source. The aim of the study was to compare the clinical efficacy of nebulised salbutamol and salbutamol metered dose inhaler (MDI) in children with mild or moderate exacerbation of Bronchial asthma.Methods: This study was a hospital based randomized control study carried out between March 2009 to December 2009 on children attending OP or casualty of Government Medical College, Alappuzha with mild or moderate exacerbation of bronchial asthma.Results: 60 subjects were selected for the study out of which 30 were assigned to salbutamol MDI group and the other 30 to salbutamol nebulisation group. After the administration of drug, all the studied variables showed significant improvement in both groups (p value <0.001). Percentage predicted PEFR increased by about 27% in nebulisation group and 26% in MDI group; however this difference was not statistically significant (P value = 0.99).Conclusions: In this study we concluded that the efficacy of salbutamol in mild or moderate acute exacerbation of asthma was similar when the drug is delivered either by nebuliser or MDI with spacer.  

scholarly journals Clinical Investigation of Pharmaceutical Instructions for the Use of a Metered Dose Inhaler by Inpatients with Bronchial Asthma.

1998 ◽  
Vol 24 (1) ◽  
pp. 63-70 ◽  
Author(s):  
FUMIYOSHI OJIMA ◽  
HIDENORI NAKAMURA ◽  
TOHRU SHOJI ◽  
HITONOBU TOMOIKE ◽  
YOSHITO NAKAGAWA
Keyword(s):  
Bronchial Asthma ◽  
Clinical Investigation ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Metered Dose

scholarly journals Comparison of clinical outcomes of inhaled formoterol or fluticasone versus formoterol or mometasone in the patients of bronchial asthma

2020 ◽  
Vol 9 (12) ◽  
pp. 1797
Author(s):  
Sharad Chadda ◽  
Mushtaq Ahmed ◽  
Tajinder Kaur ◽  
Prashant Singh ◽  
Amit Kumar Mehto
Keyword(s):  
Bronchial Asthma ◽  
Forced Expiratory Volume ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Treatment Regimens ◽  
Significant Difference ◽  
Metered Dose ◽  
Group A ◽  
The Mean ◽  
Group B

Background: This study was undertaken because of paucity of literature regarding outcomes of inhaled formeterol/fluticasone versus formoterol/mometasone in asthmatic patients.Methods: Fifty newly (male/female) recruited cases of bronchial asthma were diagnosed on the basis of spirometry. The patients were allocated to two groups viz group A and B. Group-A received mometasone furoate/formoterol (200/10 μg OD) and Group-B received fluticasone/formoterol (200/10 μg OD) respectively. The drugs were administered through metered-dose inhaler (MDI).Results: The mean FEV1/FVC ratio recorded (64.40±9.01) before starting the treatment has significantly changed to (68.92±8.58) after starting the treatment. Mean forced expiratory volume (47.56±14.73%) noted before the use of bronchodilator also changed to mean FEV1 63.98±15.17. Mean forced expiratory volume recorded before treatment (55.02±5.01) in a group who were treated with formoterol/mometasone combination changed to (72.06±5.86) after treatment. However, the mean forced expiratory volume recorded before treatment 54.92±4.47 in a group who were treated with formoterol/fluticasone combination changed to 75.48±5.03 after the treatment. While comparing the two treatment regimens, it is evident from the results that there is no significant difference in FEV1 between the groups. However, the post bronchodilator FEV1 was significantly (p<0.001) higher among the patient group which were treated with fluticasone/formoterol combination than the group who were treated with mometasone/formoterol combination. No significant adverse effect of either of two regimens was observed thus showing that both the combinations are comparatively safe for use.Conclusions: This study reveals that both the treatment regimens showed a significant improvement in lung functions without any significant adverse event.

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