Lower Antibody Response in Chickens Homozygous for the Mx Resistant Allele to Avian Influenza

SUMMARYSera of 197 apparently well persons were tested for residual haemagglutination-inhibiting antibodies against live Hong Kong/68, A/FM/47 and A/PR/34 strains. Sera of 62 well persons, regularly exposed to contacts with swine, were tested against an inactivated A/New Jersey/76 antigen.Those born some time before and during a certain influenza era showed a significantly greater proportion of homologous residual titres against the subtype prevailing in that influenza era, than those born after the termination of the same era.In each of the seven age groups tested both the percentage of positives and the geometric mean titres were usually highest against the Hong Kong strain (representing the most recent era); the next highest were those against the FM1 strain and the lowest were those against the PR8 strain (representing the most distant of these three influenza eras).The serological involvement of donors exposed to regular contacts with swine was relatively stronger against the New Jersey antigen than the response of other serum donors shown against the other three, more recent, prototypes of influenza virus A. The oldest age groups showed significantly lower antibody response against the PR8, FM1 and Hong Kong strains (but not against the New Jersey antigen) than the next one or two of the younger age groups.

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Specific antibody response of mice after immunization with COS-7 cell derived avian influenza virus (H5N1) recombinant proteins

Journal of Immune Based Therapies and Vaccines ◽

10.1186/1476-8518-5-10 ◽

2007 ◽

Vol 5 (1) ◽

pp. 10 ◽

Cited By ~ 1

Author(s):

Navin Horthongkham ◽

Tananun Srihtrakul ◽

Niracha Athipanyasilp ◽

Sontana Siritantikorn ◽

Wannee Kantakamalakul ◽

...

Keyword(s):

Influenza Virus ◽

Avian Influenza ◽

Antibody Response ◽

Avian Influenza Virus ◽

Recombinant Proteins ◽

Specific Antibody ◽

Specific Antibody Response ◽

Virus H5n1 ◽

Avian Influenza Virus H5n1

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Antibody Response and Viral Shedding Profile of Egyptian Geese (Alopochen aegyptiacus) Infected with Low Pathogenicity H7N1 and H6N8 Avian Influenza Viruses

Avian Diseases Digest ◽

10.1637/10121-992012-digest.1 ◽

2012 ◽

Vol 7 (2) ◽

pp. e9-e11

Author(s):

Christina E. Burger ◽

Celia Abolnik ◽

Geoffrey T. Fosgate

Keyword(s):

Avian Influenza ◽

Antibody Response ◽

Influenza Viruses ◽

Avian Influenza Viruses ◽

Viral Shedding

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Protective measures and human antibody response during an avian influenza H7N3 outbreak in poultry in British Columbia, Canada

Canadian Medical Association Journal ◽

10.1503/cmaj.060204 ◽

2006 ◽

Vol 176 (1) ◽

pp. 47-53 ◽

Cited By ~ 32

Author(s):

D. M. Skowronski ◽

Y. Li ◽

S. A. Tweed ◽

T. W.S. Tam ◽

M. Petric ◽

...

Keyword(s):

British Columbia ◽

Avian Influenza ◽

Antibody Response ◽

Human Antibody ◽

Protective Measures

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Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.1993.tb05965.x ◽

2008 ◽

Vol 92 (1) ◽

pp. 169-173 ◽

Cited By ~ 35

Author(s):

E. E. ARREAZA ◽

J. J. GIBBONS ◽

G. W. SISKIND ◽

M. E. WEKSLER

Keyword(s):

Antibody Response ◽

Tetanus Toxoid ◽

Idiotypic Antibody ◽

Lower Antibody Response

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Effect of recombinantfowlpox virusexpressing chicken interferon-γ on active immunity induced by avian influenza vaccines of H5 subtype in chickens

Chinese Journal of Agricultural Biotechnology ◽

10.1079/cjb200551 ◽

2005 ◽

Vol 2 (1) ◽

pp. 29-32

Author(s):

Jia Li-Jun ◽

Liu Xiu-Fan ◽

Zhang Yan-Mei ◽

Peng Da-Xin ◽

Zhang Ru-Kuan

Keyword(s):

Avian Influenza ◽

Antibody Response ◽

Protective Efficacy ◽

Interferon Γ ◽

Influenza Vaccines ◽

Inactivated Vaccine ◽

Dependent Manner ◽

Fowlpox Virus ◽

Ifn Γ ◽

H5 Subtype

AbstractTo evaluate the potential adjuvant effect of chicken interferon-γ (IFN-γ) expressed by recombinantfowlpox virus(rFPV–IFN-γ), SPF chickens and commercial chickens with (MAb+) and without (MAb−) maternal antibodies were immunized with rFPV–IFN-γ plus either H5 subtype avian influenza vaccine based on recombinantfowlpox virus(rFPV–HA) or conventional inactivated vaccine. In the assay of humoral responses, rFPV–IFN-γ plus vaccines induced a slightly lower titre of haemagglutinin inhibition (HI) antibody response than either rFPV–HA or inactivated vaccine alone, in both MAb−and MAb+chickens. As for protective efficacy, the combinations of rFPV–IFN-γ and both vaccines induced 95–100% protection against lethal challenge withhighly pathogenic avian influenza virusin SPF chickens and MAb−chickens, which were equal to those induced by either vaccine alone. However, immunization of MAb+chickens with 106pfu rFPV–HA plus 105pfu rFPV–IFN-γ showed higher protection efficacy (33.5%) than that (11.4–15.8%) induced by treatments with other dosage combinations. These findings show that IFN-γ expressed by recombinantfowlpox viruscould not promote HI antibody response induced by H5 avian influenza vaccines in chickens. The results also suggest that rFPV–IFN-γ enhances the protection of chickens in a dose-dependent and immune status-dependent manner.

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