scholarly journals Parkinson's Disease: An update on Pathophysiology, Epidemiology, Diagnosis and Management Part 5: Management Strategies

2020 ◽  
Vol 13 (3) ◽  
Author(s):  
Abdulrazak Abyad
2021 ◽  
Vol 11 (8) ◽  
pp. 1027
Author(s):  
Diego Santos García ◽  
Marta Blázquez-Estrada ◽  
Matilde Calopa ◽  
Francisco Escamilla-Sevilla ◽  
Eric Freire ◽  
...  

Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its prevalence is estimated to increase in the future. PD has a great impact on patients’ and caregivers’ lives and also entails a substantial socioeconomic burden. The aim of the present study was to examine the current situation and the 10-year PD forecast for Spain in order to optimize and design future management strategies. This study was performed using the modified Delphi method to try to obtain a consensus among a panel of movement disorders experts. According to the panel, future PD management will improve diagnostic capacity and follow-up, it will include multidisciplinary teams, and innovative treatments will be developed. The expansion of new technologies and studies on biomarkers will have an impact on future PD management, leading to more accurate diagnoses, prognoses, and individualized therapies. However, the socio-economic impact of the disease will continue to be significant by 2030, especially for patients in advanced stages. This study highlighted the unmet needs in diagnosis and treatment and how crucial it is to establish recommendations for future diagnostic and therapeutic management of PD.


2021 ◽  
Vol 50 (11) ◽  
pp. 793-800
Author(s):  
Sophie Waller ◽  
Laura Williams ◽  
Hugo Morales-Briceño ◽  
Victor SC Fung

2020 ◽  
Vol 91 (7) ◽  
pp. 703-711
Author(s):  
Mark John Kelly ◽  
Fahd Baig ◽  
Michele Tao-Ming Hu ◽  
David Okai

Impulse control behaviours (ICBs) are a range of behaviours linked by their reward-based, repetitive natures. They can be precipitated in Parkinson’s disease (PD) by dopamine replacement therapy, often with detrimental consequences for patients and caregivers. While now a well-recognised non-motor feature of treated PD, much remains unknown about the influence of risk factors, pathophysiological mechanisms, vulnerability factors for specific types of behaviour and the optimal management strategies. Imaging studies have identified structural and functional changes in striatal and prefrontal brain regions, among others. Gene association studies indicate a role for genetic predisposition to PD-ICB. Clinical observational studies have identified potential modifiable and non-modifiable risk factors. Psychological studies shed light on the neurocognitive domains implicated in PD-ICBs and identify psychosocial determinants that may perpetuate the cycle of impulsive and harm-avoidance behaviours. Based on these results, a range of pharmacological and non-pharmacological management strategies have been trialled in PD-ICBs with varying success. The purpose of this review is to update clinicians on the evidence around the pathophysiology of PD-ICB. We aim to translate our findings into an interpretable biopsychosocial model that can be applied to the clinical assessment and management of individual cases of PD-ICB.


2020 ◽  
Vol 20 (6) ◽  
pp. 619-626
Author(s):  
Srimathy Vijayan ◽  
Bhajan Singh ◽  
Soumya Ghosh ◽  
Rick Stell ◽  
Frank L. Mastaglia

Prescriber ◽  
2006 ◽  
Vol 17 (21) ◽  
pp. 56-63
Author(s):  
Graham Hughes ◽  
David Burn

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