scholarly journals Atypical Clinical Manifestations of Acute Poststreptococcal Glomerulonephritis

Author(s):  
Toru Watanabe
2020 ◽  
Vol 145 (04) ◽  
pp. 240-247
Author(s):  
Martin Kimmel

AbstractGlomerulonephritis, secondary to bacterial, or, more rarely, viral or parasitic infections, is called infection-associated. The epidemiology of infection-associated glomerulonephritis has changed in recent decades. For a long time, the classic form has been acute poststreptococcal glomerulonephritis (APGN), but in developed countries its incidence has declined sharply. However, there is an increase in staphylococcal associated glomerulonephritis (SAGN). The clinical manifestations of APGN and SAGN are different: APGN typically presents with a glomerulonephritis after an infectious latency period (post-infectious), while SAGN typically shows an immune complex glomerulonephritis concomitant with infection (para-infectious). SAGN often presents with an occult infections in older patients with multiple comorbidities.


PEDIATRICS ◽  
1967 ◽  
Vol 40 (6) ◽  
pp. 1028-1030
Author(s):  
WARREN F. DODGE ◽  
BENJAMIN H. SPARGO ◽  
LUTHER B. TRAVIS

Additional cases of acute glomerulonephritis in sibling contacts were observed in from one fourth (proven by renal biopsy) to one half (proven and suspected) of the index case sibships examined. These data suggest that the occurrence of acute glomerulonephritis in family contacts of children with sporadic acute poststreptococcal glomerulonephritis is so common as to warrant close observation of the other siblings.


2017 ◽  
Vol 18 (3-4) ◽  
pp. 75
Author(s):  
H. Alatas ◽  
I.G.N. Wila Wirya ◽  
T. Tambunan

Seventy children who were hospitalized for kidney diseases in the Nephrological ward Department of Child Health, University of Indonesia, Jakarta were used in this study. Thirty seven patients sufferfng from acute poststreptococcal Glomerulonephritis (A.G.N.), 3 patients with Membranoproliferative Glomerulonephritis (M.P.G.N.) and 30 patients with Nephrotic Syndrome due to other causes were examined for complement concentration. A total of 80 samples were examined for C3 and 25 samples for C4 concentration using the immunediffusion plates. Almost all patients with A.G.N. and M.P.G.N. showed depression of C3. C4 concentration was normal except in 2 patients, 1 with A.G.N. and the other With M.P.G.N. This suggest activation of complement at the C3 level by the alternating pathway in most of the patients. C3 concentration in A.G.N. patients returned to normal after 8-10 weeks. In MPGN the depression was persistent in 2 patients, while in 1 patient it returned to normal level after 3 months of Immunosuppressive treatment.


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