scholarly journals Ameliorative Effect of Vitamin E on Sensorimotor and Cognitive Changes Induced by Chronic Chlorpyrifos Exposure in Wistar Rats

Author(s):  
Suleiman F. ◽  
Joseph O. ◽  
Muftau Shittu ◽  
Mohammed U. ◽  
Suleiman O.





2017 ◽  
Vol 7 (3) ◽  
pp. 445
Author(s):  
Renu Singh ◽  
A.K. Srivastava ◽  
Neeraj Kumar Gangwar ◽  
Uttam Singh ◽  
Raghavendra Singh




2018 ◽  
Vol 17 (1) ◽  
pp. 1-11
Author(s):  
Bisong, Sunday Agba ◽  
Ukoh, Imoh Emmanuel ◽  
Odey, Paul ◽  
Ebong, Patrick Ekong


2020 ◽  
Vol 3 (1) ◽  
pp. 31-44
Author(s):  
Bermansyah ◽  
Gama Satria ◽  
Ahmad Umar

Introduction.Pulmonary contusions can cause a progressive inflammatory response. Activation of TNF-α cytokines and reactive oxygen species (ROS) can cause pulmonary cell death. Antioxidants can have the potential to neutralize ROS. The purpose of this study is to determine the effectiveness of antioxidant administration in maintaining pulmonary cell function in wistar rats that have been induced to experience pulmonary contusions through caspase-3 levels. Methods.This study was an in vivo experimental study conducted on thirty male wistar rats and divided into five groups (n = 6): control, pulmonary contusion + asthaxanthine 5 mg/kgBW, pulmonary contusion + vitamin C and E 50 mg/kgBW, pulmonary contusion + vitamin C and E 100 mg/kgBW, pulmonary contusion + vitamin C and E 200 mg/kgBW. The value of Caspase-3 is evaluated by the IHC. All data analyzes used SPSS 18. Results. Low doses of antioxidants have the potential to reduce pulmonary cell death in wistar rats induced by pulmonary contusions.Conclussion. Vitamin C and E effective to reduce polmonary cell death in pulmonary contusion.Keywords: antioxidants, vitamin C, vitamin E, pulmonary contusions animal model, apoptosis, caspase-3



2013 ◽  
Vol 33 (9) ◽  
pp. 911-927 ◽  
Author(s):  
SA Mansour ◽  
DA Mohamed ◽  
L Gamet-Payrastre

During gestation and lactation, the experimental mice dams received one of the following treatments: (a) diet free of pesticide; (b) diet enriched with endosulfan (END); 30.0 µg kg−1; (c) diet free of pesticide + oral vitamin E (α-tocopherol; 200 mg kg−1 per mouse); and (d) diet enriched with END (30.0 µg kg−1) + oral vitamin E (200 mg kg−1 per mouse). At weaning, pups and dams were killed, and selected organs as well as blood samples were collected for analyses. Compared with the control results, END induced alteration in a number of biochemical and histopathological parameters either in the dams or their offspring. The ameliorative effect of vitamin E to superoxide dismutase based on the “ameliorative index (AI)” for mothers and pups was 0.84 and 0.72, respectively. The AI for malondialdehyde reached a maximum value of nearly equal to 1.0 for dams or pups. For butyryl cholinesterase, the AI was 0.90 and 0.94 for dams and pups, respectively. In conclusion, a dietary exposure during gestation and lactation to low dose of END caused significant changes in the mother but also in the weaned animals that had not been directly exposed to this pesticide. These biological and histological alterations could be reversed to a great extent by oral supplementation of vitamin E.



Andrologia ◽  
2019 ◽  
Vol 52 (1) ◽  
Author(s):  
Augustine L. Udefa ◽  
Favour N. Beshel ◽  
Justina N. Nwangwa ◽  
Isaac D. Mkpe ◽  
Onisofien S. Ofuru ◽  
...  


2013 ◽  
Vol 23 (4) ◽  
pp. 829-834
Author(s):  
Nisar Ahmad Nisar ◽  
Mudasir Sultana ◽  
Naseer Ahmad Baba ◽  
Parveez Ahmad Para ◽  
Hina Ashraf Waiz ◽  
...  


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