Animal Toxicology Studies on the Male Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Data Analysis and Health Effects Evaluation

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known environmental poison that exist in the environment for many years. However, its effect on the male reproductive system has not been clearly stated. We conducted a meta-analysis of the effect of TCDD on the male reproductive system of rodents about TCDD. Results showed that that TCDD exposure reduced the testis weight (weighted mean difference [WMD]: −0.035, 95% confidence interval [CI]: −0.046 to −0.025), sperm count (WMD: −35, 95% CI: −42.980 to −27.019), and blood testosterone concentration (WMD: −0.171, 95% CI: −0.269 to −0.073). According to our research results, TCDD can cause damage to the male reproductive system of rodents through direct or indirect exposure. In order to further explore the potential hazards of TCDD to humans, more human-related research needs to be carried out.

Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study

Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients’ indirect exposure to inorganic particles, through coresidents’ occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5–7) vs 0.5 (0–2), p=0.003 and 1 (0–2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.

Exposure of Ophthalmologists to Patients' Exhaled Droplets in Clinical Practice: A Numerical Simulation of SARS-CoV-2 Exposure Risk

Background: Lack of quantification of direct and indirect exposure of ophthalmologists during ophthalmic diagnostic process makes it hard to estimate the infectious risk of aerosol pathogen faced by ophthalmologists at working environment.Methods: Accurate numerical models of thermal manikins and computational fluid dynamics simulations were used to investigate direct (droplet inhalation and mucosal deposition) and indirect exposure (droplets on working equipment) within a half-minute procedure. Three ophthalmic examination or treatment scenarios (direct ophthalmoscopic examination, slit-lamp microscopic examination, and ophthalmic operation) were selected as typical exposure distance, two breathing modes (normal breathing and coughing), three levels of ambient RH (40, 70, and 95%) and three initial droplet sizes (50, 70, and 100 μm) were considered as common working environmental condition.Results: The exposure of an ophthalmologist to a patient's expiratory droplets during a direct ophthalmoscopic examination was found to be 95 times that of a person during normal interpersonal interaction at a distance of 1 m and 12.1, 8.8, and 9.7 times that of an ophthalmologist during a slit-lamp microscopic examination, a surgeon during an ophthalmic operation and an assistant during an ophthalmic operation, respectively. The ophthalmologist's direct exposure to droplets when the patient cough-exhaled was ~7.6 times that when the patient breath-exhaled. Compared with high indoor RH, direct droplet exposure was higher and indirect droplet exposure was lower when the indoor RH was 40%.Conclusion: During the course of performing ophthalmic examinations or treatment, ophthalmologists typically face a high risk of SARS-CoV-2 infection by droplet transmission.

Detection of CWD prions in naturally infected white-tailed deer fetuses and gestational tissues by PMCA

Chronic wasting disease (CWD) is a prevalent prion disease affecting cervids. CWD is thought to be transmitted through direct animal contact or by indirect exposure to contaminated environmental fomites. Other mechanisms of propagation such as vertical and maternal transmissions have also been suggested using naturally and experimentally infected animals. Here, we describe the detection of CWD prions in naturally-infected, farmed white-tailed deer (WTD) fetal tissues using the Protein Misfolding Cyclic Amplification (PMCA) technique. Prion seeding activity was identified in a variety of gestational and fetal tissues. Future studies should demonstrate if prions present in fetuses are at sufficient quantities to cause CWD after birth. This data confirms previous findings in other animal species and furthers vertical transmission as a relevant mechanism of CWD dissemination.

Depression and Anxiety in Mothers Who Were Pregnant During the COVID-19 Outbreak in Northern Italy: The Role of Pandemic-Related Emotional Stress and Perceived Social Support

The COVID-19 pandemic is a collective trauma that is threatening citizens' mental health resulting in increased emotional stress, reduced social support, and heightened risk for affective symptoms. The present study aimed to investigate the effects of antenatal pandemic-related emotional stress and perceived social support on the symptoms of depression and anxiety of mothers who were pregnant during the initial COVID-19 outbreak in northern Italy. A sample of 281 mothers was enrolled at eight maternity units in the first hotspot region of the COVID-19 outbreak in northern Italy. Participants filled out online questionnaires assessing the direct or indirect exposure to the SARS-CoV-2 virus, pandemic-related stress, perceived social support, as well as symptoms of depression and anxiety. Depressive and anxious symptomatology was above clinical concern, respectively, in 26 and 32% of the respondents. Mothers who reported no exposure to SARS-CoV-2 during pregnancy and those who reported at least one direct or indirect exposure did not differ in terms of affective symptoms. Continuous scores and risk for severe depression and anxiety were positively associated with prenatal pandemic-related emotional stress and negatively linked with perceived social support during pregnancy. Women who become mothers during the COVID-19 emergency may be at high risk for affective problems. Dedicated preventive programs are needed to provide adequate preventive support and care for maternal mental health during and after the COVID-19 pandemic.

Mangroves and coastal topography create economic “safe havens” from tropical storms

Evidence suggests that mangroves protect economic activity in coastal areas. We estimate this protection from mangroves and coastal elevation globally, examining both “direct” and “indirect” exposure events (< 100 km vs. ≥ 100 km distance from a cyclone’s “eye”, respectively). We find that higher elevation (≥ 50 m) or wide mangroves (≥ 10 m seaward width) alone shelter economic activity from indirect cyclone exposure, whereas protection from direct cyclone exposure occurs only in high elevation communities with wide mangroves. Our results reveal that the majority of these “safe havens” are in upper middle-income countries but provide significant benefits to populations in lower middle-income countries.

Media Monopolies Increase Misperceptions about Immigration: Evidence from German Local Newspapers

We examine how local news monopolies affect misperceptions about the size of the immigrant population in Germany. We propose a theoretical framework in which heterogeneous information from different local news outlets diffuses through social inter- actions. We posit that indirect exposure to information from multiple sources leads to more accurate beliefs in competitive markets. To causally identify the effect of local news monopolies on misperceptions, we exploit overlapping newspaper coverage areas as a source of exogenous variation in the number of available outlets. We estimate that local news monopolies increase misperceptions by 38%. We empirically demonstrate that the effect of media monopolies hinges on social interactions. For individuals with fewer close social contacts, misperceptions remain unaffected by local news monopolies. Our results suggest that consolidation in the market for news decreases constituents’ knowledge about critical policy issues.

Brief and Indirect Exposure to Natural Environment Restores the Directed Attention for the Task

The mental fatigue elicited by working and studying consumed mental resources, thereby eliciting a declined performance and an increased mental stress. The long-term continuous work and study, which is typical for modern workers and students, can increase mental fatigue and health risks. Previous studies reported that the natural environment (i.e., forest and waterside) has a restorative of mental resources (i.e., attention) and reducing stress. However, it is difficult for urban workers and students to take sufficient breaks in real natural environment. We conducted an experiment to examine whether brief and indirect exposure to the natural environment elicits a restorative of attention and reducing stress. Twenty-five undergraduate and graduate students from the university of modern city participated in the experiment. The experiment involved measuring the changes in the task performance of the participants (i.e., sustained attention to response task) and the subjective mental workload (i.e., arousal, valence, and NASA-TLX), while the attention restoration was indexed from physiological response (i.e., skin conductance level, SCL) over time. The participants had two types of resting periods in the middle of the task, i.e., by looking at a blank display (simple break) or by watching a nature video having scenes of, e.g., a forest, small waterfall, and rustling leaves (nature break). The results indicate that the natural environment indirectly depicted through the nature videos does not affect the task performance and the subjective mental workload but decreases the SCL. The results of the physiological response suggest that having rest periods depicting the natural environment, even if indirectly and briefly, can restore the directed attention (i.e., mental resources) for the task. This experiment revealed a useful method of resting for urban workers and students to restore their attention to a task.

Microaggression and Implicit Bias

Microaggression is an unconscious statement or action regarded as discrimination against a marginalized community. Microaggression coupled with implicit bias (unconscious prejudice in favor or against one person or group) can be psychologically damaging to the targeted community. The difficulty with microaggressions and implicit biases is that they are subjective and unconscious, and the offender may not view them as damaging. Microaggressions and implicit biases can affect both the patient and the physician. Whether it is the patient that is the victim of these phenomena or the physician, the goal of quality patient care is adversely affected. When patients are victims, bias can also lead to systematic dismissal of symptoms, inferior medical services, and less aggressive preventive care. Physicians who are victims of such phenomena may deal with the repeated trauma of receiving microaggressions and biases from patients and/or colleagues which may cause mental distress and ultimately functional impairment affecting work performance. In either case, repeated direct and indirect exposure of microaggressions and biases through encounters within and outside the workforce are cumulative leading to lasting internalized damage. Awareness that implicit biases and microaggressions exist and recognition that these phenomena are problematic are the first steps toward fostering a more equitable and inclusive culture. As a society and especially as health care workers, we must become increasingly culturally aware and sensitive of all communities for the ultimate good of patient care.