Vitamin E administration does not ameliorate tramadol‐associated impairment of testicular function in Wistar rats

Andrologia ◽  
2019 ◽  
Vol 52 (1) ◽  
Author(s):  
Augustine L. Udefa ◽  
Favour N. Beshel ◽  
Justina N. Nwangwa ◽  
Isaac D. Mkpe ◽  
Onisofien S. Ofuru ◽  
...  
Keyword(s):  
Vitamin E ◽  
Wistar Rats ◽  
Testicular Function

scholarly journals Could Co-Administration of Panax Ginseng and Vitamin E be More Effective in Reversing Nicotine- and Chronic Stress-induced Reproductive Toxicity in Male Albino Wistar Rats?

2018 ◽  
Vol 17 (1) ◽  
pp. 1-11
Author(s):  
Bisong, Sunday Agba ◽  
Ukoh, Imoh Emmanuel ◽  
Odey, Paul ◽  
Ebong, Patrick Ekong
Keyword(s):  
Vitamin E ◽  
Panax Ginseng ◽  
Chronic Stress ◽  
Wistar Rats ◽  
Reproductive Toxicity

scholarly journals Effectiveness of Vitamin C and Vitamin E Antioxidant Combination on Caspase-3 Expression in Wistar White Rat Pulmonum Contusion

2020 ◽  
Vol 3 (1) ◽  
pp. 31-44
Author(s):  
Bermansyah ◽  
Gama Satria ◽  
Ahmad Umar
Keyword(s):  
Cell Death ◽  
Vitamin E ◽  
Vitamin C ◽  
Wistar Rats ◽  
Caspase 3 ◽  
Cell Function ◽  
Pulmonary Contusion ◽  
Tnf Α ◽  
Male Wistar Rats

Introduction.Pulmonary contusions can cause a progressive inflammatory response. Activation of TNF-α cytokines and reactive oxygen species (ROS) can cause pulmonary cell death. Antioxidants can have the potential to neutralize ROS. The purpose of this study is to determine the effectiveness of antioxidant administration in maintaining pulmonary cell function in wistar rats that have been induced to experience pulmonary contusions through caspase-3 levels. Methods.This study was an in vivo experimental study conducted on thirty male wistar rats and divided into five groups (n = 6): control, pulmonary contusion + asthaxanthine 5 mg/kgBW, pulmonary contusion + vitamin C and E 50 mg/kgBW, pulmonary contusion + vitamin C and E 100 mg/kgBW, pulmonary contusion + vitamin C and E 200 mg/kgBW. The value of Caspase-3 is evaluated by the IHC. All data analyzes used SPSS 18. Results. Low doses of antioxidants have the potential to reduce pulmonary cell death in wistar rats induced by pulmonary contusions.Conclussion. Vitamin C and E effective to reduce polmonary cell death in pulmonary contusion.Keywords: antioxidants, vitamin C, vitamin E, pulmonary contusions animal model, apoptosis, caspase-3

scholarly journals Evaluation of Aqueous Leaf Extract of Cissampelos mucronata on Testicular Function Indices in Wistar Rats

2015 ◽  
Vol 5 (4) ◽  
pp. 233-241 ◽  
Author(s):  
T. Olaolu ◽  
O. Akinwande ◽  
A. Olaolu
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Testicular Function ◽  
Aqueous Leaf Extract

Content and Redistribution of Vitamin E in Tissues of Wistar Rats Under Oxidative Stress Induced by Hydrazine

2002 ◽  
Vol 42 (3) ◽  
pp. 363-368 ◽  
Author(s):  
J. Antosiewicz, A. Matuszkiewicz, R. A
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Wistar Rats

An investigation into the effects of ketoconazole on testicular function in Wistar rats

1986 ◽  
Vol 111 (2) ◽  
pp. 246-251 ◽  
Author(s):  
A. I. Vawda ◽  
A. G. Davies
Keyword(s):  
Germ Cells ◽  
Wistar Rats ◽  
Term Treatment ◽  
Plasma Testosterone ◽  
Testicular Function ◽  
Sperm Number ◽  
Abnormal Sperm ◽  
Long Term Treatment ◽  
Sexually Mature

Abstract. Ketoconazole was administered orally to sexually mature Wistar rats and testicular function assessed. A single oral dose of 24 mg ketoconazole/kg body weight lowered plasma testosterone and DHT levels by 83 and 50%, respectively within 2 h, without altering gonadotrophin levels. Treatment for up to 7 days decreased epididvmal sperm number and motility and increased the proportion of abnormal sperm. The sperm appeared to be most affected 3 days after a single dose of ketoconazole and recovery had taken place by the seventh day. Daily treatment for up to 90 days also decreased sperm number and motility and increased the proportion of abnormal sperm, but did not affect testicular germ cells. No significant change was noted in the weights of the testis, epididymis, seminal vesicle and prostate; nor was there a change in testicular DNA, RNA and protein contents. Although fertility appeared to be impaired by long-term treatment, some of the treated rats mated successfully.

Chronic administration of gabapentin and a gabapentin-carbamazepine combination reversibly suppress testicular function in male Wistar rats ( Rattus norvegicus )

2017 ◽  
Vol 24 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Opeyemi Samson Osuntokun ◽  
Gbola Olayiwola ◽  
Ayowole Oladele ◽  
Idowu Ola ◽  
Oludele AyokaAbiodun
Keyword(s):  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Chronic Administration ◽  
Testicular Function ◽  
Male Wistar Rats

Alterations in Ca2+ homeostasis and oxidative damage induced by ethion in erythrocytes of Wistar rats: Ameliorative effect of vitamin E

2011 ◽  
Vol 31 (3) ◽  
pp. 378-386 ◽  
Author(s):  
G.K. Bhatti ◽  
J.S. Bhatti ◽  
R. Kiran ◽  
R. Sandhir
Keyword(s):  
Vitamin E ◽  
Oxidative Damage ◽  
Wistar Rats ◽  
Ameliorative Effect

scholarly journals The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet

2019 ◽  
Vol 56 (2) ◽  
pp. 337-340
Author(s):  
Daniela Miricescu ◽  
Daniela Gabriela Balan ◽  
Catalina Radulescu ◽  
Radu Radulescu ◽  
Iulia-Ioana Stanescu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Drug Delivery Systems ◽  
Wistar Rats ◽  
Male Rats ◽  
Control Group ◽  
Daily Dose ◽  
Hypercaloric Diet ◽  
Antioxidant Effects ◽  
Wistar Male Rats ◽  
Biomarkers Of Oxidative Stress

PLGA (Poli-lactic-co-glycolic acid) nanoparticles (NPs) are curently used as drug delivery systems for many types of drugs including antioxidants such as vitamin E. The main aim of our study was to test the antioxidant effects of PLGA-vitamin E on Wistar male rats. Two groups of Wistar rats received a hypercaloric diet for 21 days: the first group received besides the hypercaloric diet a daily dose of PLGA loaded with vitamin E and the control group received only the hypercaloric diet. Spleen cellular lysate has been used to detect biomarkers of oxidative stress such as malondialdehyde, glutathione, advanced human oxidative protein and vitamin E. After 3 weeks of treatment, statistical significant changes have been detected between the two groups.

scholarly journals Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

2019 ◽  
Vol 56 (3) ◽  
pp. 520-534
Author(s):  
Daniela Miricescu ◽  
Alexandra Totan ◽  
Iulia Ioana Stanescu ◽  
Andreea Didilescu ◽  
Ruxandra Sfeatcu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Wistar Rats ◽  
Plga Nanoparticles ◽  
Water Soluble ◽  
Control Group ◽  
Daily Dose ◽  
Total Antioxidant ◽  
Poorly Water Soluble ◽  
Hypercaloric Diet ◽  
Hepatic Level

The hypercaloric diet leads to obesity which is a risk factor for developing many systemic diseases such as diabetes, cardiovascular diseases and cancer. The purpose of our study was to observe the antioxidants effects of entrapped alfa-tocopherol (vitamin E) and lutein in Poly Lactic-CO-Glycolic acid (PLGA) in Wistar rats that received 3 weeks hypercaloric diet. Hepatic and splenic lysates have been used to detect changes in total antioxidant capacity (TAC) and advanced oxidative protein products (AOPP). The AOPP liver levels were statistically decreased in the case of rats groups that received a daily dose of PLGA-lutein or PLGA-vitamin E versus the control group. The AOPP level was decreased but statistically insignificant in Wistar rats spleen who received a daily dose of PLGA-lutein. At hepatic level, TAC was statistically increased in rats groups that received a daily dose of vitamin E or lutein. An increased statistical level of TAC was observed in the spleen cell lysing in Wistar rats who received the daily dose of PLGA-vitamin E. Entrapment of vitamin E and lutein in PLGA structure has diminished the effects of hypercaloric diet and can be considered a attractive and promising approach to enhance the bioavailability and activity of poorly water soluble compounds.

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