scholarly journals Myocardial Ischemia: Alterations in Myocardial Cellular Energy and Diastolic Function, a Potential Role for D-Ribose

10.5772/31620 ◽  
2012 ◽  
Author(s):  
Linda M. ◽  
J. A. St. Cyr
Keyword(s):  
Myocardial Ischemia ◽  
Diastolic Function ◽  
Potential Role ◽  
Cellular Energy

Supplementation with selenium and coenzyme Q10 in critically ill patients

2019 ◽  
Vol 80 (10) ◽  
pp. 589-593 ◽  
Author(s):  
IP Hargreaves ◽  
D Mantle
Keyword(s):  
Critically Ill ◽  
Coenzyme Q10 ◽  
Critically Ill Patients ◽  
Energy Supply ◽  
Potential Role ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Cellular Energy ◽  
And Oxidative Stress

Multiple organ dysfunction and resultant mortality in critically ill patients has been linked with impaired cellular energy supply and oxidative stress. Clinical studies supplementing selenium, on the basis of its role as a key cofactor of antioxidant enzymes, have reported variable outcomes in critically ill patients. However, the synergistic interaction between selenium and coenzyme Q10, which has essential roles in cellular energy supply and as an antioxidant, has not been considered in such studies. This article reviews the link between selenium and coenzyme Q10, and the potential role of their co-supplementation in critical illness.

Effects and Interactions of Nitrous Oxide, Myocardial Ischemia, and Reperfusion on Left Ventricular Diastolic Function

1997 ◽  
Vol 84 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Stephan Christoph Ulrich Marsch ◽  
Serge Dalmas ◽  
Daniel Michael Philbin ◽  
William Allen Ryder ◽  
Lawdy Siu Shan Wong ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Myocardial Ischemia ◽  
Diastolic Function ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Ventricular Diastolic Function

scholarly journals Mitochondria depletion abolishes agonist-induced Ca2+ plateau in airway smooth muscle cells: potential role of H2O2

2010 ◽  
Vol 298 (2) ◽  
pp. L178-L188 ◽  
Author(s):  
Taoxiang Chen ◽  
Liping Zhu ◽  
Tao Wang ◽  
Hong Ye ◽  
Kewu Huang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Potential Role ◽  
Reactive Oxygen Species Generation ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Cellular Energy ◽  
Dependent Mechanism

The mechanisms by which mitochondria regulate the sustained phase of agonist-induced responses in cytosolic Ca2+ concentration as an independent organelle in whole is not clear. By exposing to ethidium bromide and supplying pyruvate and uridine, we established mitochondrial DNA (mtDNA)-depleted rat airway smooth muscle cells (RASMCs) with maintained cellular energy. Upon an exposure to 2 μM histamine, [Ca2+]i in control RASMCs increased to a peak followed by a plateau above baseline, whereas [Ca2+]i in mtDNA-depleted RASMCs jumped to a peak and then declined to baseline without any plateau. mtDNA depletion apparently attenuated intracellular reactive oxygen species generation induced by histamine. By coexposure to 2 μM histamine and 0.1 μM exogenous H2O2, which did not affect [Ca2+]i by itself, the above difference in [Ca2+]i kinetics in mtDNA-depleted RASMCs was reversed. Intracellular H2O2 decomposition abolishes histamine-induced sustained elevation in [Ca2+]i in RASMCs. Thus, mitochondria regulate agonist-induced sustained [Ca2+]i elevation by a H2O2-dependent mechanism.

scholarly journals Effects and Interactions of Nitrous Oxide, Myocardial Ischemia, and Reperfusion on Left Ventricular Diastolic Function

1997 ◽  
Vol 84 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Stephan Christoph Ulrich Marsch ◽  
Serge Dalmas ◽  
Daniel Michael Philbin ◽  
William Allen Ryder ◽  
Lawdy Siu Shan Wong ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Myocardial Ischemia ◽  
Diastolic Function ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Ventricular Diastolic Function
Sign in / Sign up

Export Citation Format

Share Document