scholarly journals The Plant and Protist Organellar DNA Replication Enzyme POP Showing Up in Place of DNA Polymerase Gamma May Be a Suitable Antiprotozoal Drug Target

10.5772/51975 ◽  
2013 ◽  
Author(s):  
Takashi Moriyama ◽  
Naoki Sato
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Drug Target ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma ◽  
Organellar Dna

Isolation of DNA polymerase gamma from an adenovirus 2 DNA replication complex.

1975 ◽  
Vol 15 (6) ◽  
pp. 1507-1510 ◽  
Author(s):  
K Ito ◽  
M Arens ◽  
M Green
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Polymerase Gamma ◽  
Replication Complex ◽  
Dna Polymerase Gamma

Role of DNA polymerase .gamma. in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates

Biochemistry ◽  
1981 ◽  
Vol 20 (9) ◽  
pp. 2628-2632 ◽  
Author(s):  
Peter C. Van der Vliet ◽  
Marijke M. Kwant
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Polymerase Gamma ◽  
Replication Mechanism ◽  
Dna Polymerase Gamma ◽  
Mechanism Of Inhibition

scholarly journals Inventory and Evolution of Mitochondrion-localized Family A DNA Polymerases in Euglenozoa

Pathogens ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 257 ◽  
Author(s):  
Ryo Harada ◽  
Yoshihisa Hirakawa ◽  
Akinori Yabuki ◽  
Yuichiro Kashiyama ◽  
Moe Maruyama ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerases ◽  
Dna Polymerase I ◽  
Bacterial Dna ◽  
Polymerase Gamma ◽  
Origin And Evolution ◽  
Dna Polymerase Gamma ◽  
Unique Biology ◽  
Organellar Dna ◽  
Polymerase I

The order Trypanosomatida has been well studied due to its pathogenicity and the unique biology of the mitochondrion. In Trypanosoma brucei, four DNA polymerases, namely PolIA, PolIB, PolIC, and PolID, related to bacterial DNA polymerase I (PolI), were shown to be localized in mitochondria experimentally. These mitochondrion-localized DNA polymerases are phylogenetically distinct from other family A DNA polymerases, such as bacterial PolI, DNA polymerase gamma (Polγ) in human and yeasts, “plant and protist organellar DNA polymerase (POP)” in diverse eukaryotes. However, the diversity of mitochondrion-localized DNA polymerases in Euglenozoa other than Trypanosomatida is poorly understood. In this study, we discovered putative mitochondrion-localized DNA polymerases in broad members of three major classes of Euglenozoa—Kinetoplastea, Diplonemea, and Euglenida—to explore the origin and evolution of trypanosomatid PolIA-D. We unveiled distinct inventories of mitochondrion-localized DNA polymerases in the three classes: (1) PolIA is ubiquitous across the three euglenozoan classes, (2) PolIB, C, and D are restricted in kinetoplastids, (3) new types of mitochondrion-localized DNA polymerases were identified in a prokinetoplastid and diplonemids, and (4) evolutionarily distinct types of POP were found in euglenids. We finally propose scenarios to explain the inventories of mitochondrion-localized DNA polymerases in Kinetoplastea, Diplonemea, and Euglenida.

59 Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphism in mitochondrial disorders

Mitochondrion ◽  
2007 ◽  
Vol 7 (6) ◽  
pp. 421
Author(s):  
Matthew J. Longley ◽  
William C. Copeland ◽  
Sherine S.L. Chan
Keyword(s):  
Dna Polymerase ◽  
Mitochondrial Disorders ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma

Inhibition of Autophagy Reveals a Novel Mechanism by Which DNA Polymerase Gamma (Pol-y) Prevents Cancer Development

2015 ◽  
Vol 87 ◽  
pp. S65
Author(s):  
Sanjit Kumar Dhar ◽  
Vasu Bakthavatchalu ◽  
Bithika Dhar ◽  
Izumi Tadahide ◽  
Jing Chen ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Cancer Development ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma

The expanding clinical and pathologic spectrum of mitochondrial DNA polymerase gamma mutations

2007 ◽  
Vol 66 (5) ◽  
pp. 437
Author(s):  
Michael A. Farrell ◽  
Rachel Howley ◽  
Yazan Alderazi ◽  
Francesca Brett ◽  
Joan Moroney ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma ◽  
Mitochondrial Dna Polymerase

102 Yeast homologues of disease mutations in DNA polymerase gamma cause mtDNA depletion and mutagenesis

Mitochondrion ◽  
2010 ◽  
Vol 10 (2) ◽  
pp. 228
Author(s):  
Jeffrey D. Stumpf ◽  
Diana Spell ◽  
Matthew Stillwagon ◽  
Karen S. Anderson ◽  
William C. Copeland
Keyword(s):  
Dna Polymerase ◽  
Polymerase Gamma ◽  
Mtdna Depletion ◽  
Dna Polymerase Gamma ◽  
Disease Mutations
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