scholarly journals Acupuncture Effects on Bladder Activity and State of Vigilance Through GABAergic Neuronal Systems

10.5772/55405 ◽  
2013 ◽  
Author(s):  
Yoshimasa Koyama ◽  
Hui Wang







Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 361
Author(s):  
Myeongwoo Jung ◽  
Eun-Kyung Lee

HuD (also known as ELAVL4) is an RNA–binding protein belonging to the human antigen (Hu) family that regulates stability, translation, splicing, and adenylation of target mRNAs. Unlike ubiquitously distributed HuR, HuD is only expressed in certain types of tissues, mainly in neuronal systems. Numerous studies have shown that HuD plays essential roles in neuronal development, differentiation, neurogenesis, dendritic maturation, neural plasticity, and synaptic transmission by regulating the metabolism of target mRNAs. However, growing evidence suggests that HuD also functions as a pivotal regulator of gene expression in non–neuronal systems and its malfunction is implicated in disease pathogenesis. Comprehensive knowledge of HuD expression, abundance, molecular targets, and regulatory mechanisms will broaden our understanding of its role as a versatile regulator of gene expression, thus enabling novel treatments for diseases with aberrant HuD expression. This review focuses on recent advances investigating the emerging role of HuD, its molecular mechanisms of target gene regulation, and its disease relevance in both neuronal and non–neuronal systems.



2010 ◽  
Vol 20 (4) ◽  
pp. 043140 ◽  
Author(s):  
Hao Wu ◽  
Zhonghuai Hou ◽  
Houwen Xin
Keyword(s):  


2003 ◽  
Vol 23 (5) ◽  
pp. 293-299
Author(s):  
Irina Virtanen ◽  
Eeva Ekholm ◽  
Tero Aittokallio ◽  
Jarno Tähtinen ◽  
Jussi Salmi ◽  
...  


Life Sciences ◽  
1998 ◽  
Vol 62 (23) ◽  
pp. 2101-2108
Author(s):  
M. Muraoka ◽  
H. Hayakawa ◽  
A. Kagaya ◽  
T. Kojima ◽  
S. Yamawaki


1990 ◽  
Vol 534 (1-2) ◽  
pp. 177-187 ◽  
Author(s):  
Linda E. Muske ◽  
Frank L. Moore


2004 ◽  
Vol 14 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Holly R. Middlekauff ◽  
Janki B. Shah ◽  
Jun Liang Yu ◽  
Kakit Hui


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