scholarly journals Emerging Targeted Therapies for Treatment of Hepatocellular Carcinoma (HCC)

2018 ◽  
Author(s):  
Sarwat Fatima ◽  
Nikki Pui-Yue Lee ◽  
Hiu Yee Kwan ◽  
Zhao Xiang Bian
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapies

Targeted Therapies in Hepatocellular Carcinoma

2014 ◽  
Vol 21 (8) ◽  
pp. 966-974 ◽  
Author(s):  
F. Bronte ◽  
G. Bronte ◽  
S. Cusenza ◽  
E. Fiorentino ◽  
C. Rolfo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapies

Toward improving androgen receptor-targeted therapies in male-dominant hepatocellular carcinoma

2021 ◽  
Author(s):  
Hong Zhang ◽  
Kristen Spencer ◽  
Stephen K. Burley ◽  
X.F. Steven Zheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Androgen Receptor ◽  
Targeted Therapies

Molecular-Targeted Therapies in Hepatocellular Carcinoma

2019 ◽  
pp. 225-238 ◽  
Author(s):  
Amit Mahipal ◽  
Anuhya Kommalapati ◽  
Rutika Mehta ◽  
Richard D. Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapies ◽  
Molecular Targeted Therapies

192 New targeted therapies strategies in hepatocellular carcinoma - In vitro studies

2010 ◽  
Vol 8 (7) ◽  
pp. 64-65
Author(s):  
A.M. Araújo ◽  
S. Sousa Neves ◽  
A.L. Ferreira ◽  
J.D. Branco ◽  
A.B. Sarmento Ribeiro ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapies ◽  
In Vitro Studies

Treatment of Hepatocellular Carcinoma – Integrating Loco-regional and Molecular-targeted Therapies

2010 ◽  
Vol 06 (01) ◽  
pp. 65
Author(s):  
Riccardo Lencioni ◽  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapies ◽  
Early Stage ◽  
Systemic Exposure ◽  
Intermediate Stage ◽  
High Rate ◽  
Interventional Treatment ◽  
Rf Ablation ◽  
Thermal Methods ◽  
Molecular Targeted Therapies

The treatment of hepatocellular carcinoma (HCC) is rapidly evolving as loco-regional and systemic therapies continue to improve. Image-guided radiofrequency (RF) ablation is established as the treatment of choice for patients with early-stage HCC when transplantation or resection are precluded. Recent refinements to technique have substantially increased the ability of RF ablation to achieve sustained complete response of target tumours in properly selected patients, and new alternate thermal and non-thermal methods for local tumour treatment are currently under investigation. Transarterial chemo-embolisation (TACE) is the standard of care for patients with multinodular disease at the intermediate stage. The introduction of drug-eluting beads, which enhance drug delivery to the tumour and reduce systemic exposure, appears to improve anticancer activity and the safety profile of TACE compared with conventional regimens. Despite these advances, the long-term outcomes of patients treated with loco-regional therapies remain unsatisfactory because of the high rate of tumour recurrence. The introduction of molecular-targeted therapies that inhibit tumour proliferation and angiogenesis has opened new prospects in this regard. Clinical trials focused on combining interventional treatment with systemically active drugs are ongoing. The outcomes of such studies are eagerly awaited, as they have the potential to revolutionise the treatment of HCC.

scholarly journals Targeted Therapies in the Treatment of Advanced Hepatocellular Carcinoma

2013 ◽  
Vol 7 ◽  
pp. CMO.S7633 ◽  
Author(s):  
Zhengyu Wei ◽  
Cataldo Doria ◽  
Yuan Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapies ◽  
Recent Progress ◽  
Systemic Treatment ◽  
Advanced Hepatocellular Carcinoma ◽  
Advanced Hcc ◽  
The Third ◽  
Promising Target ◽  
Targeted Treatments ◽  
Attractive Option

Hepatocellular carcinoma (HCC) is the most common liver cancer and the third leading cause of cancer death. It has been a major worldwide health problem with more new cases being diagnosed each year. The current available therapies for patients with advanced HCC are extremely limited. Therefore, it is of great clinical interests to develop more effective therapies for systemic treatment of advanced HCC. Several promising target-based drugs have been tested in a number of clinical trials. One breakthrough of these efforts is the approved clinical use of sorafenib in patients with advanced HCC. Targeted therapies are becoming an attractive option for the treatment of advanced HCC. In this review, we summarize the most recent progress in clinical targeted treatments of advanced HCC.

From Molecular Biology to Targeted Therapies for Hepatocellular Carcinoma: The Future Is Now

Oncology ◽  
2007 ◽  
Vol 72 (1) ◽  
pp. 30-44 ◽  
Author(s):  
Roberta W.C. Pang ◽  
Ronnie T.P. Poon
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Biology ◽  
Targeted Therapies ◽  
The Future
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