scholarly journals Current Status for Application of RNA Interference Technology as Nucleic Acid Drug

2018 ◽  
Author(s):  
Tomoko Takahashi ◽  
Yuko Nakano ◽  
Kumiko Ui-Tei
Keyword(s):  
Rna Interference ◽  
Nucleic Acid ◽  
Current Status ◽  
Nucleic Acid Drug

scholarly journals Current Status and Potential of RNA Interference for the Management of Tomato Spotted Wilt Virus and Thrips Vectors

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 320
Author(s):  
Alexander Nilon ◽  
Karl Robinson ◽  
Hanu R. Pappu ◽  
Neena Mitter
Keyword(s):  
Rna Interference ◽  
Tomato Spotted Wilt Virus ◽  
Cultural Practices ◽  
Management Strategies ◽  
Current Status ◽  
Horticultural Crops ◽  
Yield And Quality ◽  
Tomato Spotted Wilt ◽  
Wilt Virus

Tomato spotted wilt virus (TSWV) is the type member of the genus Orthotospovirus in the family Tospoviridae and order Bunyavirales. TSWV, transmitted by several species of thrips, causes significant disease losses to agronomic and horticultural crops worldwide, impacting both the yield and quality of the produce. Management strategies include growing virus-resistant cultivars, cultural practices, and managing thrips vectors through pesticide application. However, numerous studies have reported that TSWV isolates can overcome host-plant resistance, while thrips are developing resistance to pesticides that were once effective. RNA interference (RNAi) offers a means of host defence by using double-stranded (ds) RNA to initiate gene silencing against invading viruses. However, adoption of this approach requires production and use of transgenic plants and thus limits the practical application of RNAi against TSWV and other viruses. To fully utilize the potential of RNAi for virus management at the field level, new and novel approaches are needed. In this review, we summarize RNAi and highlight the potential of topical or exogenous application of RNAi triggers for managing TSWV and thrips vectors.

Nucleic acid hepatitis B virus (HBV) vaccine: current status

1998 ◽  
Vol 13 (1) ◽  
pp. 71-79 ◽  
Author(s):  
M Irshad
Keyword(s):  
Hepatitis B Virus ◽  
Nucleic Acid ◽  
Hepatitis B ◽  
Current Status ◽  
Hbv Vaccine ◽  
B Virus

Commercialization of Nucleic Acid Probe Technology: Current Status

1994 ◽  
pp. 121-129
Author(s):  
James H. Godsey ◽  
Kurt M. Vanden Brink ◽  
Luke J. DiMichele ◽  
Laura A. Beninsig ◽  
W. Richard Peterson ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Current Status

scholarly journals Cover Picture: Nanopore-Based Analysis of Chemically Modified DNA and Nucleic Acid Drug Targets (Isr. J. Chem. 6-7/2013)

2013 ◽  
Vol 53 (6-7) ◽  
pp. 317-317
Author(s):  
Joseph Larkin ◽  
Spencer Carson ◽  
Daniel H. Stoloff ◽  
Meni Wanunu
Keyword(s):  
Nucleic Acid ◽  
Drug Targets ◽  
Chemically Modified ◽  
Modified Dna ◽  
Nucleic Acid Drug

RNA interference with 2′,4′-bridged nucleic acid analogues

2010 ◽  
Vol 18 (10) ◽  
pp. 3474-3480 ◽  
Author(s):  
S.M. Abdur Rahman ◽  
Hiroyuki Sato ◽  
Naoto Tsuda ◽  
Sunao Haitani ◽  
Keisuke Narukawa ◽  
...  
Keyword(s):  
Rna Interference ◽  
Nucleic Acid ◽  
Nucleic Acid Analogues

DAPI - pUC8 complex: A tool to investigate biological effects of nucleic acid-drug interaction

1987 ◽  
Vol 145 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Giorgio Palu' ◽  
Sebastiano Valisena ◽  
Maria Luisa Barcellona ◽  
Lanfranco Masotti ◽  
Giovanni A. Meloni
Keyword(s):  
Drug Interaction ◽  
Nucleic Acid ◽  
Biological Effects ◽  
Nucleic Acid Drug
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