scholarly journals Transplantation or Transference of Cultured Cells as a Treatment for Spinal Cord Injury

2019 ◽  
Author(s):  
Roxana Rodríguez-Barrera ◽  
Karla Soria-Zavala ◽  
Julián García-Sánchez ◽  
Lisset Karina Navarro-Torres ◽  
Estefanía de la Cruz Castillo ◽  
...  

Author(s):  
Roxana Rodríguez-Barrera ◽  
Marcela Garibay-López ◽  
Antonio Ibarra

Spinal cord injury (SCI) is an important pathology leading to possibly fatal consequences. The most common repercussions are those affecting motor and sensitivity skills. SCI-damage occurs in its first phase—as a result of the lesion mechanism (contusion, compression, transection, and primary lesion). After this primary damage, there is a second phase with further deleterious effects on neural degeneration and tissue restoration. At the moment, several investigation groups are working on developing therapeutic strategies to induce neuroprotection. This chapter pretends to introduce the reader to a wide range of these therapies, particularly those with promising results and tested in preclinical and clinical studies. In the first section, physiopathology of SCI will be addressed. Afterwards, the chapter will review neuroprotective strategies such as cyclooxygenase, calpain, and apoptosis inhibitors. Finally, the effect of immunophilin ligands, neural-derived peptides, antioxidants, hypoglycemic agent, gonadal hormones, Na channel blockers, and transplant of cultured cells will also be reviewed.





2005 ◽  
Vol 173 (4S) ◽  
pp. 11-12
Author(s):  
Jeffrey K. Lou ◽  
Daniel S. McPartlin ◽  
Adam P. Klausner


2005 ◽  
Vol 173 (4S) ◽  
pp. 308-308
Author(s):  
Jeffrey L. Evans ◽  
Henry Lai ◽  
Mustafa Ozen ◽  
Bhuvaneswari Krishnan ◽  
Michael Ittmann ◽  
...  


2005 ◽  
Vol 173 (4S) ◽  
pp. 307-308 ◽  
Author(s):  
Christopher E. Kelly ◽  
Chuan-Guo Xiao ◽  
Howard Weiner ◽  
Aleksandar Beric ◽  
Victor W. Nitti ◽  
...  


2006 ◽  
Vol 175 (4S) ◽  
pp. 525-525
Author(s):  
Charles M. Lynne ◽  
Nancy L. Brackett ◽  
Teodoro C. Aballa ◽  
Emad Ibrahim ◽  
Apostolos Kafetsoulis


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