Monoglycerides as an Antifungal Agent

2020 ◽  
Author(s):  
Febri Odel Nitbani ◽  
Jumina Jumina
Keyword(s):  
Antifungal Agent

Antibiotics from the newly isolatedStreptomyces elizabethii. I. Production of a polyene antifungal agent (Elizabethin) and actinomycin in shake flask cultures

1981 ◽  
Vol 31 (1) ◽  
pp. 167-177 ◽  
Author(s):  
S. John Pirt ◽  
Susan M. A. Pickett ◽  
Andrew M. Pickett ◽  
Erick J. Vandamme ◽  
Clive W. Bird
Keyword(s):  
Antifungal Agent ◽  
Shake Flask

Clinical effect for tinea disease of a antifungal agent for external use, bifonazole.

1991 ◽  
Vol 53 (5) ◽  
pp. 1061-1065
Author(s):  
SHOZO MOTOFUSA
Keyword(s):  
Antifungal Agent ◽  
Clinical Effect

Synthesis of Grafted Biodegradable Poly(ε-caprolactone) as Antibacterial and Antifungal Agent

2020 ◽  
Vol 62 (6) ◽  
pp. 697-705
Author(s):  
Sarra Benguella ◽  
Aicha Hachemaoui ◽  
Ahmed Yahiaoui ◽  
Abdelkader Dehbi
Keyword(s):  
Antifungal Agent ◽  
Biodegradable Poly ◽  
Antibacterial And Antifungal

scholarly journals Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Lindsey Cass ◽  
Alison Murray ◽  
Amanda Davis ◽  
Kathy Woodward ◽  
Muna Albayaty ◽  
...  
Keyword(s):  
Antifungal Agent ◽  
Clinical Pharmacokinetics

scholarly journals Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent

2019 ◽  
Vol 194 ◽  
pp. 65-73 ◽  
Author(s):  
Dimitris Matiadis ◽  
Dimitrios Tsironis ◽  
Valentina Stefanou ◽  
Alysha G. Elliott ◽  
Konstantinos Kordatos ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Antifungal Agent ◽  
Tetramic Acid ◽  
X Ray

scholarly journals Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yun C. Chang ◽  
Ami Khanal Lamichhane ◽  
Hongyi Cai ◽  
Peter J. Walter ◽  
John E. Bennett ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
High Frequency ◽  
Antifungal Agent ◽  
Inhibitory Concentration ◽  
Glucuronic Acid ◽  
Rapid Development ◽  
Acid Synthesis ◽  
Transcriptional Factor ◽  
Development Of Resistance ◽  
Acid Accumulation

AbstractThe antifungal agent 5-fluorocytosine (5-FC) is used for the treatment of several mycoses, but is unsuitable for monotherapy due to the rapid development of resistance. Here, we show that cryptococci develop resistance to 5-FC at a high frequency when exposed to concentrations several fold above the minimal inhibitory concentration. The genomes of resistant clones contain alterations in genes relevant as well as irrelevant for 5-FC resistance, suggesting that 5-FC may be mutagenic at moderate concentrations. Mutations in FCY2 (encoding a known permease for 5-FC uptake), FCY1, FUR1, UXS1 (encoding an enzyme that converts UDP-glucuronic acid to UDP-xylose) and URA6 contribute to 5-FC resistance. The uxs1 mutants accumulate UDP-glucuronic acid, which appears to down-regulate expression of permease FCY2 and reduce cellular uptake of the drug. Additional mutations in genes known to be required for UDP-glucuronic acid synthesis (UGD1) or a transcriptional factor NRG1 suppress UDP-glucuronic acid accumulation and 5-FC resistance in the uxs1 mutants.

ChemInform Abstract: The Antifungal Agent 1-(2-(4-Chlorobenzylamino)benzyl)-1H-imidazole.

ChemInform ◽  
2010 ◽  
Vol 28 (41) ◽  
pp. no-no
Author(s):  
A. ETTORRE ◽  
M. BIAVA ◽  
R. FIORAVANTI ◽  
G. C. PORRETTA
Keyword(s):  
Antifungal Agent
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