Antibiotics from the newly isolatedStreptomyces elizabethii. I. Production of a polyene antifungal agent (Elizabethin) and actinomycin in shake flask cultures

1981 ◽  
Vol 31 (1) ◽  
pp. 167-177 ◽  
Author(s):  
S. John Pirt ◽  
Susan M. A. Pickett ◽  
Andrew M. Pickett ◽  
Erick J. Vandamme ◽  
Clive W. Bird
Keyword(s):  
Antifungal Agent ◽  
Shake Flask

Antibiotics from the newly isolated Streptomyces elizabethii. I. Production of a polyene antifungal agent (Elizabethin) and actinomycin in shake flask cultures

2007 ◽  
Vol 31 (1) ◽  
pp. 167-177 ◽  
Author(s):  
S. John Pirt ◽  
Susan M. A. Pickett ◽  
Andrew M. Pickett ◽  
Erick J. Vandamme ◽  
Clive W. Bird
Keyword(s):  
Antifungal Agent ◽  
Shake Flask

Synthesis of Grafted Biodegradable Poly(ε-caprolactone) as Antibacterial and Antifungal Agent

2020 ◽  
Vol 62 (6) ◽  
pp. 697-705
Author(s):  
Sarra Benguella ◽  
Aicha Hachemaoui ◽  
Ahmed Yahiaoui ◽  
Abdelkader Dehbi
Keyword(s):  
Antifungal Agent ◽  
Biodegradable Poly ◽  
Antibacterial And Antifungal

scholarly journals Effect of methyl substituent on the solubility of 1,4-benzoquinone derivatives in n-octanol/water system

2020 ◽  
Vol 23 (5) ◽  
pp. 142-146
Author(s):  
Siti Mariyah Ulfa ◽  
Fath Dwisari ◽  
Ade Cintyia Sally ◽  
Mohammad Farid Rahman
Keyword(s):  
Shake Flask ◽  
Water System ◽  
Insertion Reaction ◽  
Log P ◽  
Methyl Substituent ◽  
Promising Candidate ◽  
New Drug ◽  
Alkyl Bromides ◽  
Ft Ir ◽  
Uv Visible

The solubility of the compound is a crucial task for new drug design. Quinone is a promising candidate to develop as a new drug. In this research, the synthesis of 1,4-benzoquinone derivatives, that is, 2-(5-bromoamyl)-3,5-dimethyl-1,4-benzoquinone (2a) and 2-(5-bromoamyl)-5-methyl-1,4-benzoquinone (2b) were carried out by decarboxylation and insertion reaction of alkyl bromides. The product 2a and 2b are purified using SiO2 gel column chromatography and analyzed by UV-Visible, FT-IR, and NMR. The yield of 2a is 13.75%, and 2b is 4.04%. The solubility of 2a and 2b, expressed by log P, is measured in the n-octanol/water (3:7 (v/v)) system by the shake flask method. The log P of 2a and 2b are 2.99 and 1.36, respectively. It is showed that the log P of 2a is higher compared to 2b. The presence of two methyl substituents on the quinone ring of 2a supports the increase of hydrophobicity of the compound in the n-octanol/water system.

scholarly journals Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Lindsey Cass ◽  
Alison Murray ◽  
Amanda Davis ◽  
Kathy Woodward ◽  
Muna Albayaty ◽  
...  
Keyword(s):  
Antifungal Agent ◽  
Clinical Pharmacokinetics

PRODUCTION OF CYTASES ACTIVE ON BARLEY GUM BY BACTERIA OF THE GENUS BACILLUS

1953 ◽  
Vol 31 (1) ◽  
pp. 28-32 ◽  
Author(s):  
A. C. Blackwood
Keyword(s):  
Bacillus Subtilis ◽  
Enzymatic Activity ◽  
Nitrogen Source ◽  
Freeze Drying ◽  
Shake Flask ◽  
Sole Nitrogen Source ◽  
Genus Bacillus ◽  
Original Activity ◽  
Bacterial Cultures ◽  
Bacillus Genus

One hundred and fourteen bacterial cultures representing most of the species in the Bacillus genus were tested for the production of extracellular barley gum cytase. Assays were made on shake-flask cultures grown on a medium containing glucose and yeast extract. Although all the organisms had some enzymatic activity, certain strains of Bacillus subtilis gave the best yields of cytase. On a medium with asparagine as the sole nitrogen source even higher yields were obtained. The crude cytase preparations were stable and after freeze-drying most of the original activity remained.

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