scholarly journals Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune Thrombocytopenic Purpura

2020 ◽  
Vol 4 (3) ◽  
pp. 421-423
Author(s):  
Melanie Randall ◽  
Jason Nurse ◽  
Karan Singh

Introduction: Immune thrombocytopenic purpura (ITP) is an autoimmune-mediated disorder in which the body produces antibodies that destroy platelets, causing an increased risk of bleeding and bruising. Tranexamic acid (TXA) is a medication that prevents clot breakdown and is used to treat uncontrolled bleeding. Case Report: We present the case of an 11-year-old female with significant epistaxis and hypotension in the emergency department. Traditional therapies were initiated; however, the patient continued to have bleeding and remained hypotensive, so intravenous TXA was given. The patient’s bleeding then resolved. Conclusion: TXA may be a safe and effective adjunct to traditional therapies for the treatment of life-threatening hemorrhage in ITP patients.

CHEST Journal ◽  
2016 ◽  
Vol 150 (4) ◽  
pp. 392A ◽  
Author(s):  
Gautam Sikka ◽  
Aditya Gupta ◽  
Moses Bachan ◽  
Zinobia Khan

2020 ◽  
Vol 11 (4) ◽  
pp. 153-155
Author(s):  
Carmela R. Nanton ◽  
Sharon M. Martin ◽  
Lloyd O. Cook ◽  
Patricia J. Larison

2015 ◽  
Vol 2 ◽  
Author(s):  
Bessy S. Flores-Chang ◽  
Carlos E. Arias-Morales ◽  
Francis G. Wadskier ◽  
Sorab Gupta ◽  
Nicoleta Stoicea

2018 ◽  
Vol 25 (2) ◽  
pp. 114-116
Author(s):  
Heiner Frei

Background: Conventional or homeopathic treatment of chronic immune thrombocytopenic purpura (ITP) is often difficult. The use of homeopathic dilutions of patient blood (HPB) for immunomodulation has been described, which inspired us to try the method in an ITP case. Case Report: A 2-year-old girl with chronic ITP was treated with homeopathic dilutions of her own capillary blood, given orally over 5 months. Immediately after treatment onset there was a rapid normalization of the thrombocyte counts. Within 6 weeks, they rose from 15,000/µl to 254,000/µl. After treatment stop, they decreased to 155,000/µl, increased again spontaneously to 270,000/µl and remained within normal range for over 3 years. Conclusions: Oral administration of homeopathic dilutions of capillary patient blood may possibly be an effective treatment in chronic ITP. If our results can be reproduced, this will revolutionize the treatment of ITP.


Author(s):  
Zahra Khalighi ◽  
Golnaz Azami ◽  
Elham Shafiei ◽  
Ali Sahebi ◽  
Aliashraf Mozafari

Background: Thrombotic Thrombocytopenic Purpura (TTP) is a rare and life-threatening disorder characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, fever, renal dysfunction, and neurological deficient. TTP leads to the formation of blood clots in small blood vessels throughout the body. TTP is associated with many risk factors such as pregnancy, HIV, cancer, lupus, and infections. Recently there have been few published case reports of bee sting associated TTP.Methods: A 67-year-old man from a rural area of the Southwest Province of Iran, Ilam, was referred to the academic general hospital because of fever, chills, sweating, vomiting and dizziness following the honeybee sting on his body. Results: this study showed that,multiple co-morbidities including CVD and diabetes, along with coagulation abnormalities after honeybee stings, seriously exacerbated patient hemodynamic status.Conclusion: TTP, as a major complication due to the toxic reaction of a large number of bee stings with underlying diseases in patients, should be given more attention.


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