Case Report of a Patient with a Rare and Life-Threatening Disorder: Thrombotic Thrombocytopenic Purpura

Abstract Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy with clinical quintuple symptoms, including fever, thrombocytopenia, microangiopathic hemolytic anemia, neurological symptoms, and renal insufficiency. TTP onset in children is rare, and the percentage of acute TTP with these five symptoms at the same time is <10%. In this study, we reported a typical case of TTP onset in a child with clinical quintuple symptoms.

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Acquired thrombotic thrombocytopenic Purpura diagnosed during first trimester of pregnancy with excellent outcome after plasma exchange and rituximab, a case report

Clinical Case Reports ◽

10.1002/ccr3.3752 ◽

2021 ◽

Vol 9 (3) ◽

pp. 1304-1306

Author(s):

Javier Arzuaga‐Mendez ◽

Maite Moreno ◽

Juan J. Mateos‐Mazón ◽

Miriam Vara ◽

Marta Dueñas ◽

...

Keyword(s):

Case Report ◽

Plasma Exchange ◽

Thrombotic Thrombocytopenic Purpura ◽

First Trimester ◽

Thrombocytopenic Purpura ◽

Excellent Outcome ◽

First Trimester Of Pregnancy

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Effectiveness of bortezomib in the treatment of thrombotic thrombocytopenic purpura: Case report

Medicina Clínica (English Edition) ◽

10.1016/j.medcle.2018.06.010 ◽

2019 ◽

Vol 152 (6) ◽

pp. 244-245

Author(s):

Eva Hernández Lorente ◽

Rafael Lluch García ◽

Emilio Monteagudo Santolaya

Keyword(s):

Case Report ◽

Thrombotic Thrombocytopenic Purpura ◽

Thrombocytopenic Purpura

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Chronic relapsing thrombotic thrombocytopenic purpura in pregnancy: A case report

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767059609018409 ◽

1996 ◽

Vol 5 (6) ◽

pp. 328-332

Author(s):

S. Puza ◽

M. P. Malee

Keyword(s):

Case Report ◽

Thrombotic Thrombocytopenic Purpura ◽

Thrombocytopenic Purpura ◽

In Pregnancy

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An Early Unexpected Immune Thrombotic Thrombocytopenic Purpura Relapse Associated with SARS-CoV-2 Infection: A Case Report and Literature Review

Acta Haematologica ◽

10.1159/000514283 ◽

2021 ◽

pp. 1-5

Author(s):

Maya Kornowski Cohen ◽

Liron Sheena ◽

Yair Shafir ◽

Vered Yahalom ◽

Anat Gafter-Gvili ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Case Report ◽

Thrombotic Thrombocytopenic Purpura ◽

Lupus Erythematosus ◽

Response To Therapy ◽

Intravascular Hemolysis ◽

Systemic Lupus ◽

Thrombocytopenic Purpura ◽

History Of ◽

Triggering Factor

SARS-CoV-2 has been reported as a possible triggering factor for the development of several autoimmune diseases and inflammatory dysregulation. Here, we present a case report of a woman with a history of systemic lupus erythematosus and antiphospholipid syndrome, presenting with concurrent COVID-19 infection and immune thrombotic thrombocytopenic purpura (TTP). The patient was treated with plasma exchange, steroids, and caplacizumab with initial good response to therapy. The course of both TTP and COVID-19 disease was mild. However, after ADAMTS-13 activity was normalized, the patient experienced an early unexpected TTP relapse manifested by intravascular hemolysis with stable platelet counts requiring further treatment. Only 3 cases of COVID-19 associated TTP were reported in the literature thus far. We summarize the literature and suggest that COVID-19 could act as a trigger for TTP, with good outcomes if recognized and treated early.

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