scholarly journals Malignant Melanoma Presenting as a Parotid Mass in a Middle-aged Woman with Metastasis to the Breast

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Fereshteh Ameli ◽  
Dorsa Ghasemi ◽  
Vahid Soleimani ◽  
Amirmohsen Jalaeefar
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Correct Diagnosis ◽  
Short Interval ◽  
Neck Region ◽  
Primary Breast Tumor ◽  
Immune Reactivity ◽  
Nerve Sheath Tumor ◽  
Malignant Melanomas ◽  
Aged Woman

Introduction: Malignant melanomas of the parotid gland are relatively uncommon and usually seen as metastases from cutaneous or mucous sites of the head and neck region. Some malignant melanomas may metastasize before they regress. Therefore, identifying the primary origin of metastatic melanoma is sometimes difficult. Furthermore, metastasis to the breast from an extramammary site is uncommon and challenging. It may present as a well-defined rounded mass that histopathologically mimics the various architecture and cellular phenotypes. In addition, the immunohistochemical stains of some metastatic melanomas are equivocal and challenging. Case Presentation: We presented a case of parotid gland malignant melanoma in a 42-year-old woman with metastasis to the breast in a short interval. Biopsy of parotid and breast lesions showed loss of immune-reactivity for several melanoma markers and was initially considered as malignant peripheral nerve sheath tumor and primary breast tumor, respectively. Conclusions: This case highlights the importance of obtaining past clinical history in surgical pathology cases to make a correct diagnosis. It also enhances our understanding regarding malignant melanoma as a mysterious tumor with various morphology and immunophenotype.

scholarly journals Metastatic Malignant Melanoma of Parotid Gland with a Regressed Primary Tumor

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
M. Mustafa Kılıçkaya ◽  
Giray Aynali ◽  
Ali Murat Ceyhan ◽  
Metin Çiriş
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Head And Neck ◽  
Primary Tumor ◽  
Primary Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Malignant Melanomas ◽  
Pigmented Lesions

Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient’s old photographs may help in the detection of preexisting and regressed pigmented lesions in the facial and neck regions.

scholarly journals Malignant melanoma of the bladder: A case report

2014 ◽  
Vol 8 (1-2) ◽  
pp. 54 ◽  
Author(s):  
Hamide Sayar ◽  
Seyda Erdogan ◽  
Fulya Adamhasan ◽  
Esma Gurbuz ◽  
Mehmet Fatih İnci
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Immunohistochemical Staining ◽  
Correct Diagnosis ◽  
Primary Lesion ◽  
Histological Features ◽  
Malignant Melanomas ◽  
Metastatic Lesions ◽  
S 100 ◽  
Hmb 45

Primary malignant melanoma of the bladder is very rare. Rather than being a primary lesion, malignant melanomas of the bladder are more commonly metastatic lesions. The histopathological appearance largely does not differ from that of melanoma at other body sites. It is often difficult to discriminate whether a bladder melanoma is primary or metastatic. Therefore, a careful review of histological features and performing necessary immunohistochemical staining procedures for S-100 protein and HMB-45 are very important in achieving a correct diagnosis. We report a case of hypomelanotic malignant melanoma of the bladder. Despite the variety of therapies available for primary melanomas of the bladder, the prognosis is still poor.

scholarly journals A Clinical Characters and Prognosis Analysis on 15 Cases With Malignant Melanoma in the Head and Neck

2020 ◽  
Author(s):  
Xiaodong Liu ◽  
Weixian Liu ◽  
Qiuxu Wang
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Head And Neck ◽  
Histopathological Examination ◽  
Maxillofacial Surgery ◽  
Neck Region ◽  
Surgical Excision ◽  
Pathological Examination ◽  
Oral And Maxillofacial Surgery ◽  
Golden Standard

Abstract Objective: We analyze the pathogenesis, clinical characteristics, diagnosis, treatment and histological feature of Malignant Melanoma in the head and neck. To improve the understanding and help the early diagnosis and treatment of the disease. As a result, improve the treatment and prognosis of Malignant Melanoma in head and neck.Method: We collect 15 cases of Malignant Melanoma in the head and neck region treated in the Department of Oral and Maxillofacial Surgery in Shengjing Hospital of China Medical University. All data were obtained from patient’s medical records which including the pathogenesis, clinical and histological features, diagnosis, treatment and prognosis.Result: This study included 15 cases, there are 9 male and 6 female patients. The average age is 62.9 years lid, the oldest one is 75 years old and the youngest one is 40 years old. 2 cases occurred in the lip, 2 cases occurred in the tongue, 2 cases occurred in the submandibular area, 1 cases occurred in the parotid gland, 1 case occurred in the neck, other 7 cases occurred in the gingiva. The cases occurred in the lip, gingiva, tongue, parotid gland and submandibular area are primary tumor, cases occurred in neck were metastasis. 6 cases were treated by surgical excision. 1 cases occurred in gingiva was treated by surgical excision combine with chemotherapy. 5 years followed up has been taken. 10 cases were dead because of recurrence and metastasis in 5 years after the operation. 5 patients do not have a relapse and still alive.Conclusion: Malignant Melanoma in the head and neck are mostly affected the old people. In this study gingiva is the most commonly primary site, neck is the most commonly transferring site. The diagnosis of malignant Melanoma is mainly relying on the clinical manifestation and pathological examination. Histopathological examination is considered the golden standard for diagnosis. Surgical excision combined with chemotherapy is the main treatment modality for Malignant Melanoma. Cryotherapy and immunotherapy also have been used in the treatment. The prognosis of Malignant Melanoma is poor. So early detection and early treatment is important in the treatment.

Metastatic Malignant Melanoma in Prepubertal Children

PEDIATRICS ◽  
1975 ◽  
Vol 55 (2) ◽  
pp. 191-204
Author(s):  
Daniel J. Trozak ◽  
Willard D. Rowland ◽  
Funan Hu
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Correct Diagnosis ◽  
Metastatic Malignant Melanoma ◽  
Epithelioid Cell ◽  
Low Grade ◽  
Microscopic Appearance ◽  
Malignant Melanomas ◽  
Real Nature ◽  
Benign Nevi

Medical literature is full of involved and Confusing reports on the genesis, incidence, and development of metastatic melanoma in children. The reason for this confusion can be found in the early uncertainties that surrounded the real nature and correct diagnosis of metastatic melanoma in the prepubertal child. Before 1950, reports of melanomas with metastases in children were rare, poorly documented, and in many cases erroneous.1-4 In particular, benign nevi (now known as benign juvenile melanoma) went unrecognized and because of their alarming microscopic features were often diagnosed as malignant melanomas. For example, deceived by the predilection of this nevus for childhood, its frightening appearance, and failure to metastasize, Pack and Anglem wrote: ". . . . although malignant melanomas are found in infancy and childhood, they are of low grade malignancy and seldom metastasize" In a later paper, Pack6 coined the term "prepubertal melanoma" for those nonmetastasizing pigmented tumors of children which were microscopically indistinguishable from melanoma. He suggested removal before puberty when endocrinologic stimulation rendered certain of them capable of metastasis. Other investigators also noted this seeming disparity between microscopic appearance and clinical behavior.7 In 1948, Spitz8 provided the criteria for separating this unusual-looking nevus from malignant melanoma and termed it "juvenile melanoma." Later she and Allen9 showed that although these lesions are not restricted to children, they are much more common before puberty.* Subsequent authors10-13 have also classified juvenile melanoma among the benign nevi and the term spindle or epithelioid cell nevus10,12,13 is now preferred. McWhorter and Woolner13 in 1954 reviewed the subject of malignant melanoma in children and suggested that the favorable prognosis was spurious and due to the erroneous classification of spindle and epithelioid cell nevi under the former agnosis.

Magnetic Resonance Imaging of Uncommon Hepatic Mesenchymal Tumours: Haemangioendothelioma and Angiosarcoma

2019 ◽  
Vol 15 (4) ◽  
pp. 362-368
Author(s):  
Andrzej Cieszanowski ◽  
Agnieszka Anysz-Grodzicka ◽  
Joanna Podgorska ◽  
Beata Jagielska ◽  
Jakub Pałucki
Keyword(s):  
Contrast Enhancement ◽  
Correct Diagnosis ◽  
Malignant Potential ◽  
Hepatobiliary Phase ◽  
Imaging Features ◽  
Liver Tumours ◽  
Aged Woman ◽  
High Apparent Diffusion Coefficient ◽  
Adc Values ◽  
Mesenchymal Tumours

<P>Background: Primary Hepatic Epithelioid Haemangioendothelioma (HEHE) and Primary Hepatic Angiosarcoma (PHA) are rare mesenchymal tumours with different malignant potential. Whereas HEHE demonstrates low to intermediate malignant potential, PHA is an aggressive malignancy with poor prognosis. The knowledge of typical imaging features of these lesions may facilitate correct diagnosis; however, the ultimate diagnosis of HEHE and PHA is based on histopathologic examination. </P><P> Discussion: The most typical findings helpful in diagnosing HEHE are: Presence of multiple, confluent nodules located at the liver periphery (in young to middle-aged woman), retraction of the liver capsule, marked hyperintensity on T2-weighted images, “target-sign” appearance, progressive centripetal contrast enhancement, and relatively high Apparent Diffusion Coefficient (ADC) values. More than &#8805;50% of nodules are hyper- or isointense on Hepatobiliary Phase (HBP) images. Conclusion: The imaging features suggestive of PHA are: Occurrence of metastases (lungs, spleen) at the time of diagnosis, presence of a large dominant mass with smaller satellites, heterogeneity and areas of haemorrhage in a dominant mass, progressive contrast enhancement, slightly elevated ADC values as compared to other malignant liver tumours.</P>

Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region

2005 ◽  
Vol 36 (7) ◽  
pp. 724-731 ◽  
Author(s):  
Stefania Staibano ◽  
Stefano Pepe ◽  
Lorenzo Lo Muzio ◽  
Pasquale Somma ◽  
Massimo Mascolo ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Adenosine Diphosphate ◽  
Head And Neck Region ◽  
Malignant Melanomas

scholarly journals Microcystic/Reticular Schwannoma of the Frontal Lobe: An Unusual Occurrence

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Lauren Pearson ◽  
Erinc Akture ◽  
Julien Wonderlick ◽  
Gregory Fuller ◽  
Maryam Zenali
Keyword(s):  
Frontal Lobe ◽  
Cranial Nerves ◽  
Neck Region ◽  
Nerve Sheath Tumor ◽  
Head And Neck Region ◽  
Peripheral Nerve Sheath Tumor ◽  
Reticular Pattern ◽  
Nerve Sheath ◽  
First Case ◽  
Unusual Occurrence

Schwannoma is a benign peripheral nerve sheath tumor that typically involves cranial nerves of the head and neck region. Intraparenchymal occurrence of this tumor is uncommon. Even rarer in this site is the microcystic/reticular pattern of schwannoma. This histologic variant, first described in 2008, has a predilection for visceral organs. Herein, we report the first case of microcystic/reticular schwannoma of the frontal lobe.

scholarly journals Large-extension osteosarcoma with involvement of multiple maxillofacial structures: a rare case report

2020 ◽  
Vol 9 (10) ◽  
pp. e1519108461
Author(s):  
Rani Iani Costa Gonçalo ◽  
Cristiane Kalinne Santos Medeiros ◽  
Humberto Pereira Chaves Neto ◽  
Janaina Lessa de Moraes dos Santos ◽  
Adriano Rocha Germano ◽  
...  
Keyword(s):  
Rare Case ◽  
Correct Diagnosis ◽  
Malignant Neoplasm ◽  
Neck Region ◽  
Primary Treatment ◽  
Histopathological Diagnosis ◽  
Anatomical Structures ◽  
Case Presentation ◽  
Head And Neck Region ◽  
Rare Case Report

Background: Osteosarcoma is a malignant neoplasm that occurs most often in long bones, with the head and neck region being rarely affected, accounting for less than 1% of all cancers in this region. Objective: To report a rare case of a large-extension osteosarcoma with emphasis on its clinical and diagnostic aspects. Case presentation: A 43-year-old woman presenting an intraoral exophytic lesion with involvement of other maxillofacial structures, such as nostril, zygoma and orbit. Despite the initial clinical diagnosis of actinomycosis, an incisional biopsy confirmed the histopathological diagnosis of osteosarcoma, showing a wide morphological variety. Conclusion: This case highlights the importance of clinical and histopathological findings for the correct diagnosis of osteosarcoma. Moreover, it shows that, although surgical resection is the primary treatment for this neoplasia, depending on the extent of the tumor and its proximity to vital anatomical structures, the most appropriate conduct is not always feasible.

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