scholarly journals Effect of Sesame Lignan Supplementation on Carotid Intima-Media Thickness, Serum Lipid Profile, Serum VEGF, VCAM-1, ICAM-1 and vWF Levels in Cardiovascular Disease Patients

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Marzieh Mokhber ◽  
Ali Keshavarz ◽  
Farzad Shidfar ◽  
Abbas Hadji Akhundi ◽  
Hamidreza Pouraliakbar ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Fasting Blood Glucose ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Levels ◽  
Serum Lipid Profile ◽  
Controlled Clinical Trial ◽  
Media Thickness ◽  
Sesame Lignans

Background: Atherosclerosis is a chronic inflammatory disease of the vascular wall which can alter the whole vascular system of both the aorta and coronary arteries. Sesame seeds are one of the richest sources of dietary lignans which exhibit diverse functions and valuable effects such as anti-hypertensive, anti-inflammatory, and anti-oxidative activities. Objectives: In this study, the Effect of sesame lignans on carotid intima-media thickness (CIMT), serum lipid profile, and serum levels of VEGF, VCAM-1, ICAM-1 and vWF were evaluated in cardiovascular (CVD) patients. Methods: In this double-blind, randomized, placebo-controlled clinical trial, thirty-six CVD patients who were candidates for angiography participated for 10 weeks. The subjects were asked to use 500 mg/day sesame lignans (lignan group, n = 19) or placebo (placebo group (starch), n = 17). The CIMT was measured by ultrasound and fasting blood samples were taken before and after the intervention. Results: Sesame lignans supplementation showed a significant decrease in both left and right CIMT, serum lipid profile, fasting blood glucose, and ICAM-1 serum levels compared to baseline and placebo (P < 0.05). Conclusions: These findings indicate that sesame lignans may contribute to the reduction of CIMT and prevent future cardiovascular events and so may be considered as a complementary therapeutic approach in CVD

scholarly journals The correlation between serum lipid profile with carotid intima-media thickness and plaque

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Caie Yang ◽  
Zhiqiang Sun ◽  
Yunpeng Li ◽  
Junping Ai ◽  
Qiyu Sun ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Lipid Profile ◽  
Media Thickness

scholarly journals Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Stepanka Pruhova ◽  
Petra Dusatkova ◽  
Pavel J. Kraml ◽  
Michal Kulich ◽  
Zdena Prochazkova ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Macrovascular Complications ◽  
Family Status ◽  
Dominant Form ◽  
Media Thickness ◽  
Mutation Carriers ◽  
Mild Hyperglycemia ◽  
Autosomal Dominant Form

Aim.GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY.Methods.Twenty-seven GCK mutation carriers and 24 controls recruited among their first-degree relatives were compared, all aging over 35 years. The CIMT was tested using a high-resolution B-mode carotid ultrasonography. Medical history, anthropometry, and biochemical blood workup were obtained.Results.The mean CIMT was 0.707 ± 0.215 mm (mean ± SD) in GCK mutation carriers and 0.690 ± 0.180 mm in control individuals. When adjusted for age, gender, and family status, the estimated mean difference in CIMT between the two groups increased to 0.049 mm (P=0.19). No difference was detected for other characteristics, with the exception of fasting blood glucose (GCK-MODY 7.6 mmol/L ± 1.2 (136.4 mg/dL); controls 5.3 mmol/L ± 0.3 (95.4 mg/dL);P<0.0001) and glycated hemoglobin HbA1c(GCK-MODY 6.9% ± 1.0%, 52 mmol/mol ± 10; controls 5.7% ± 0.4%, 39 mmol/mol ± 3;P<0.0001). The frequency of myocardial infarction and ischemic stroke did not differ between groups.Conclusion.Our data indicate that the persistent hyperglycemia in GCK-MODY is associated with a low risk of developing diabetic macrovascular complications.

Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial

2019 ◽  
Vol 121 (7) ◽  
pp. 809-817 ◽  
Author(s):  
Hamid Reza Talari ◽  
Mehrafrouz Zakizade ◽  
Alireza Soleimani ◽  
Fereshteh Bahmani ◽  
Amir Ghaderi ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Insulin Metabolism ◽  
Double Blind Placebo ◽  
Media Thickness ◽  
Hs Crp

AbstractThis study evaluated the effects of Mg administration on carotid intima–media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n27) or placebo (n27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P<0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=–9·42 pmol/l; 95% CI –14·94, –3·90;P=0·001), homoeostasis model of assessment-insulin resistance (β=–0·56; 95 % CI –0·89, –0·24;P=0·001) and HbA1c (β=–0·74 %; 95 % CI –1·10, –0·39;P<0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01;P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=–0·30 mmol/l; 95% CI –0·56, –0·04;P=0·02), LDL-cholesterol (β=–0·29 mmol/l; 95% CI –0·52, –0·05;P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P<0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P<0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.

Inverse correlation of carotid intima-media thickness with raloxifene serum levels in osteoporosis

2014 ◽  
Vol 126 (13-14) ◽  
pp. 403-408
Author(s):  
Tina Trdan Lušin ◽  
Aleš Mrhar ◽  
Janja Marc ◽  
Jurij Trontelj ◽  
Andrej Zavratnik ◽  
...  
Keyword(s):  
Inverse Correlation ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Levels ◽  
Media Thickness

scholarly journals Lipid Profile and Carotid Intima-Media Thickness in a Prospective Cohort of Very Preterm Subjects at Age 19 Years: Effects of Early Growth and Current Body Composition

2006 ◽  
Vol 59 (4 Part 1) ◽  
pp. 604-609 ◽  
Author(s):  
Martijn J J Finken ◽  
Akin Inderson ◽  
Nadine Van Montfoort ◽  
Mandy G Keijzer-Veen ◽  
Anton W M van Weert ◽  
...  
Keyword(s):  
Body Composition ◽  
Lipid Profile ◽  
Prospective Cohort ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Early Growth ◽  
Very Preterm ◽  
Media Thickness

P.089 CAROTID INTIMA-MEDIA THICKNESS IN NON-SMOKING HIV PATIENTS TREATED WITH ANTIRETROVIRAL THERAPY: FOCUS ON LIPID PROFILE

2007 ◽  
Vol 1 (S1) ◽  
pp. S48 ◽  
Author(s):  
N. Wiinberg* ◽  
A.M. Lebech ◽  
U.S. Kristoffersen ◽  
B. Hesse ◽  
J. Gerstoft ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Lipid Profile ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Hiv Patients ◽  
Media Thickness
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