scholarly journals The Effect of Lemon Inhalation Aromatherapy on Nausea and Vomiting of Pregnancy: A Double-Blinded, Randomized, Controlled Clinical Trial

2014 ◽  
Vol 16 (3) ◽  
Author(s):  
Parisa Yavari kia ◽  
Farzaneh Safajou ◽  
Mahnaz Shahnazi ◽  
Hossein Nazemiyeh
Keyword(s):  
Clinical Trial ◽  
Nausea And Vomiting ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled ◽  
Double Blinded

scholarly journals Efficacy of intravenous infusions of UC-derived MSCs for the treatment of COVID-19: A structured summary of a phase II double blinded, randomized controlled clinical trial

2020 ◽  
Author(s):  
Muhammad Ali ◽  
Azra Mehmood ◽  
Moazzam Nazeer Tarar ◽  
John D Gottsch ◽  
Zafar Nawaz ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Inflammatory Responses ◽  
Standard Of Care ◽  
Convincing Evidence ◽  
Controlled Clinical Trial ◽  
Immune Reactivity ◽  
Randomized Controlled Clinical Trial ◽  
Beneficial Effects ◽  
Randomized Controlled ◽  
Double Blinded

Abstract In this clinical research project, we will conduct a highly rigorous clinical trial where we randomize the patients between umbilical cord (UC)-derived mesenchymal stem cell (MSC) and standard of care (SOC). This study will ask the question whether the allogenic MSCs are effective in reducing death and/or progression of COVID-19 disease when administered to patients with moderate to severe symptoms. MSCs are unique group of cells with minimal immune reactivity and produce multiple beneficial effects, which include reduction of severe inflammatory reaction. There is convincing evidence from human studies that intravenous (IV) delivery of MSCs can directly impact the hyper-inflammatory responses of COVID-19 induced injury of the heart and lungs. Our study will evaluate the safety and efficacy of allogenic UC-derived MSCs administered intravenously to COVID-19 patients with moderate to severe symptom in a randomized, controlled clinical trial. In addition, we will determine whether : (i) UC-derived MSCs are effective in reducing 30-day all-cause mortality (primary endpoint) and (ii) UC-derived MSCs are effective in preventing progression to mechanical ventilation, and/or reducing an inflammatory response, and/or improving overall patient condition (secondary endpoints).

scholarly journals Unnecessary Overtreatment Index: a useful tool in family practice

2015 ◽  
Vol 10 (35) ◽  
pp. 1-2
Author(s):  
Mohammad Zakaria Pezeshki ◽  
Sina Pezeshki
Keyword(s):  
Clinical Trial ◽  
Family Practice ◽  
External Validity ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled ◽  
Double Blinded ◽  
Quaternary Prevention

One of the most important aspects of quaternary prevention is avoiding the exposure of the patients to unnecessary overtreatment.  In this commentary we explain how a valid and reliable double blinded randomized controlled clinical trial (RCT) with a good external validity may help a physician to estimate the magnitude of unnecessary overtreatment.

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