scholarly journals Effects of Acellular Amniotic Membrane Matrix and Bone Marrow-Derived Mesenchymal Stem Cells in Improving Random Skin Flap Survival in Rats

2016 ◽  
Vol 18 (6) ◽  
Author(s):  
Farzaneh Chehelcheraghi ◽  
Hossein Eimani ◽  
Seyed Homayoonsadraie ◽  
Giti Torkaman ◽  
Abdollah Amini ◽  
...  
2012 ◽  
Vol 8 (3) ◽  
pp. 844-853 ◽  
Author(s):  
Matthias A. Reichenberger ◽  
Wolf Mueller ◽  
Amelia Schäfer ◽  
Sina Heimer ◽  
Uwe Leimer ◽  
...  

2014 ◽  
Vol 163 (3) ◽  
pp. 200-210 ◽  
Author(s):  
Che Man Rohaina ◽  
Kong Yong Then ◽  
Angela Min Hwei Ng ◽  
Wan Haslina Wan Abdul Halim ◽  
Aida Zairani Mohd Zahidin ◽  
...  

2020 ◽  
Vol 1 (4) ◽  
pp. 01-08
Author(s):  
Farzaneh Chehelcheraghi ◽  
Khadijah Rezazadeh ◽  
Khatereh Anbari

Background and Objective: Wound dressing and healing in diabetic patients is encountered with many problems. This study aimed to investigate the effect of bone marrow derived mesenchymal stem cells (BM-MSCs) on the survival of random skin flap (RSF) on Streptozotocin-induced diabetic rats (STZ) using an optical microscope. Materials & Methods: In this study, 60 male Albino Wistar rats were used (average weight 250-300 gr). The rats were divided into six groups: 1) Health-Non (HN), 2) Health-Cells (HC), 3) Health-Sham (HS), 4) Diabetic-Non (DN) that were became diabetic by injecting STZ 70 mg/kg intraperitoneally), 5) Diabetic-Sham (DS), and 6) Diabetic-Cell (DC). In all groups, the day of surgery was considered as the zero day, on the back area of animal, the flap was created with a size of 8 × 3 cm and the BM-MSCs were performed. The sampling was performed on day 7 after surgery from the region where Transitional Zone (TZ) necrosis was initiated. Results: BM-MSCs increased the number of blood vessels (P=0.009) and the histology parameters (wound demarcation P=0.0001, granulation tissue P=0.0001) significantly compared to the control group. But this increase was not significant in the area of the survival region. Conclusion: It was concluded that after treatment with BM-MSCs, the wound healing process in both non-diabetic and diabetic groups was increased in accordance with histological characteristics.


2018 ◽  
Vol 22 (5) ◽  
pp. 322-330 ◽  
Author(s):  
Farzaneh Chehelcheraghi ◽  
Abolfazl Abbaszadeh ◽  
Magid Tavafi ◽  
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