scholarly journals Evaluation of Gluten-Free Diet Efficacy for Improving Quality of Life of Patients with Celiac Disease

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Pezhman Alavinejad ◽  
Yosra Shafiolleh Talokdar ◽  
Zahra Shokati Ashkiki
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Cross Sectional Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Cross Sectional ◽  
Khuzestan Province ◽  
Before And After ◽  
One Year

Background: As the only effective treatment of celiac disease (CD) is a lifelong commitment to a gluten-free diet (GFD), this study was designed to evaluate the efficacy of GFD in the quality of life (QOL) of patients with CD to persuade them for strict commitment. Methods: In a cross-sectional study, the QOL of CD patients registered in the celiac society of Khuzestan province was evaluated and compared before and at least one year after commencing GFD using the QOL SF-36 questionnaire. Results: Overall, 200 CD patients (66 males and 134 females) were evaluated. The average age of male and female participants was 26.3 and 30.34 years, respectively (61% between 20 and 60-years-old). After GFD, complaints such as bloating (P = 0.001), abdominal pain (P = 0.001), diarrhea (P = 0.001), nausea (P = 0.001), vomiting (P = 0.03), reflux and regurgitation (P = 0.025), anorexia (P = 0.001), fatigue (P = 0.001), headache (P = 0.008), oral aphthous lesions (P = 0.014), weight loss (P = 0.001), and bone pain (P = 0.005) significantly improved while other symptoms such as muscular pain (P = 0.157), dermatitis (P = 0.083), and numbness (P = 0.317) did not show any major improvement. The average scores of QOL before and after GFD were 0.74 and 3.41, respectively, which demonstrated significant improvement (P = 0.001). This improvement was even seen among cases with sub-optimal compliance (average QOL score 3.28, P = 0.001). Conclusion: A gluten-free diet could significantly improve the quality of life of patients with celiac disease, and they should be encouraged as much as possible to be committed to this regimen.

655 Health-Related Quality of Life in Adolescents With Screening-Detected Celiac Disease: Assessments Before Diagnosis and After One Year With Gluten-Free Diet

2014 ◽  
Vol 146 (5) ◽  
pp. S-114
Author(s):  
Anna Myléus ◽  
Solveig Petersen ◽  
Anneli Carlsson ◽  
Solveig Hammarroth ◽  
Lotta Högberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
One Year

scholarly journals The impact of symptoms on quality of life before and after diagnosis of coeliac disease: the results from a Polish population survey and comparison with the results from the United Kingdom

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Emilia Majsiak ◽  
Magdalena Choina ◽  
Dominik Golicki ◽  
Alastair M. Gray ◽  
Bożena Cukrowska
Keyword(s):  
Quality Of Life ◽  
United Kingdom ◽  
Coeliac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
The United Kingdom ◽  
Before And After ◽  
The Mean ◽  
The Uk

Abstract Background Coeliac disease (CD) is characterised by diverse clinical symptoms, which may cause diagnostic problems and reduce the patients’ quality of life. A study conducted in the United Kingdom (UK) revealed that the mean time between the onset of coeliac symptoms and being diagnosed was above 13 years. This study aimed to analyse the diagnostic process of CD in Poland and evaluate the quality of life of patients before and after CD diagnosis. In addition, results were compared to the results of the original study conducted in the UK. Methods The study included 2500 members of the Polish Coeliac Society. The patients were asked to complete a questionnaire containing questions on socio-demographic factors, clinical aspects and quality of life, using the EQ-5D questionnaire. Questionnaires received from 796 respondents were included in the final analysis. Results The most common symptoms reported by respondents were bloating (75%), abdominal pain (72%), chronic fatigue (63%) and anaemia (58%). Anaemia was the most persistent symptom, with mean duration prior to CD diagnosis of 9.2 years, whereas diarrhoea was observed for the shortest period (4.7 years). The mean duration of any symptom before CD diagnosis was 7.3 years, compared to 13.2 years in the UK. CD diagnosis and the introduction of a gluten-free diet substantially improved the quality of life in each of the five EQ-5D-5L health dimensions: pain and discomfort, anxiety and depression, usual activities, self-care and mobility (p < 0.001), the EQ-Index by 0.149 (SD 0.23) and the EQ-VAS by 30.4 (SD 28.3) points. Conclusions Duration of symptoms prior to the diagnosis of CD in Poland, although shorter than in the UK, was long with an average of 7.3 years from first CD symptoms. Faster CD diagnosis after the onset of symptoms in Polish respondents may be related to a higher percentage of children in the Polish sample. Introduction of a gluten-free diet improves coeliac patients’ quality of life. These results suggest that doctors should be made more aware of CD and its symptoms across all age groups.

T02.02.9 QUALITY OF LIFE IN CELIAC PATIENTS ON A GLUTEN FREE DIET: A CROSS SECTIONAL EVALUATION

2020 ◽  
Vol 52 ◽  
pp. S87-S88
Author(s):  
I. Marsilio ◽  
C. Canova ◽  
C. Marinelli ◽  
B. Barberio ◽  
A. D'Odorico ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Cross Sectional

scholarly journals Latiglutenase treatment for celiac disease: symptom and quality of life improvement for seropositive patients on a gluten‐free diet

GastroHep ◽  
2019 ◽  
Vol 1 (6) ◽  
pp. 293-301 ◽  
Author(s):  
Jack A. Syage ◽  
Peter H.R. Green ◽  
Chaitan Khosla ◽  
Daniel C. Adelman ◽  
Jennifer A. Sealey‐Voyksner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Disease Symptom ◽  
Gluten Free ◽  
Life Improvement

scholarly journals Evaluation of Quality of Life of Adult Patients with Celiac Disease in Argentina: From Questionnaire Validation to Assessment

2020 ◽  
Vol 17 (19) ◽  
pp. 7051
Author(s):  
Nicole Selleski ◽  
Renata Puppin Zandonadi ◽  
Laura B. Milde ◽  
Lenora Gandolfi ◽  
Riccardo Pratesi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Representative Sample ◽  
Cross Sectional Study ◽  
Extensive Experience ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Related Quality ◽  
Health Related

This cross-sectional study aimed to translate, culturally adapt, validate, and apply a Celiac Disease Quality of Life (CD-QoL) questionnaire to a representative sample of Argentina’s celiac population. A previously developed and validated questionnaire (Celiac Disease Questionnaire: CDQ) was chosen as a tool for assessing the health-related quality of Life (HRQoL) of adult celiac patients in Argentina. Therefore, the study was performed in four stages: (a) translation and re-translation of the CDQ to Argentinian-Spanish language; (b) cultural adaptation and semantic evaluation; based on the Delphi method (c) validation of the CDQ by applying it to a representative sample of Argentinian celiac patients; (d) statistical analysis of the data. The result of stages (a) and (b) was a translated and culturally adapted an Argentinian-Spanish version of the CDQ, which was generated after reaching consensus between the corresponding four (phase a) and 10 (phase b) professionals involved in the different phases of this process. Among them, we can cite bilingual healthcare professionals with extensive experience in research and celiac disease, celiac patients, gastroenterologists, general practitioners, dieticians, and psychologists. The resulting CDQ proved to be an appropriate measuring tool to assess the HRQoL of Argentinian celiac patients confirmed by a good fit in the confirmatory factor validity analysis (RMSEA < 0.001 and χ2 = 267.325, df = 313, p = 0.971) and high values of internal consistency (Cronbach’s alpha > 0.7). A total of 191 participants accessed the questionnaire, and 171 individuals from 20 out of 23 Argentinian states completed the questionnaire. There was no correlation between higher educational level nor marital status with QoL. Individuals on a strict gluten-free diet (GFD) and those who do not take antidepressants showed higher QoL. Male gender also presented better HRQoL. There was no correlation between differences in HRQoL and age of the respondent, age at diagnosis, symptoms at diagnosis, or having other chronic diseases. However, a significantly higher score of HRQoL was reported among those individuals who disclosed having knowledge of CD related national regulations and benefits. This study highlights the importance of maintaining current public health regulations that support chronic disease patients, such as celiac patients.

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