Epithelial Displacement in Breast Lesions: A Papillary Phenomenon

2005 ◽  
Vol 129 (11) ◽  
pp. 1465-1469 ◽  
Author(s):  
Chandandeep Nagi ◽  
Ira Bleiweiss ◽  
Shabnam Jaffer
Keyword(s):  
Epithelial Cells ◽  
Invasive Carcinoma ◽  
Nipple Discharge ◽  
Clinical Information ◽  
Mucinous Carcinoma ◽  
Needle Aspiration ◽  
Intraductal Papilloma ◽  
Patient Specific ◽  
Papillary Lesions ◽  
Hematoxylin Eosin

Abstract Context.—Displacement of epithelial cells (DE) in the breast may occur after various types of needling procedures. Objective.—To determine if specific lesions or entities in the breast are more prone to displacement than others. Design.—A review of our computer files from January 1994 to June 2004 yielded 53 cases with DE. Clinical information, including the age of the patient, specific reason for the biopsy, and type of biopsy, was gathered. Histologic review of all hematoxylin-eosin–stained slides (core biopsies and excisions) was performed. Results.—Needling procedures included 1 or more of the following: ultrasound-guided core biopsy (24 cases), mammotome core biopsies (16), fine-needle aspiration (8), anesthetic injection (3), suture placement (5), and wire localization (1). Procedures were performed in order to investigate a mass (34 cases), calcifications (15), both (3), or nipple discharge (1). The time from needling to surgical procedure yielding a specimen with DE ranged from minutes to 47 days. Displacement of epithelial cells occurred in the following sites: biopsy tract (42 cases), lymphatic channels (5), both biopsy tract and lymphatic channels (4), and breast stroma (2). The diagnoses included intraductal papilloma (6 cases) and intraductal carcinoma (DCIS) (45; 15 with invasive carcinoma). The remaining 2 cases were invasive carcinoma (colloid and papillary types) devoid of DCIS. Of the DCIS cases, either pure or with invasive carcinoma, the pattern was micropapillary in 23, intraductal papilloma involved by DCIS in 32, and both features in 12. The remaining 2 cases of DCIS included comedo DCIS and cribriform DCIS involving a cyst. Conclusions.—With the exception of 3 cases, DE was associated with 1 or more underlying papillary lesions, including pure intraductal papilloma, DCIS involving intraductal papilloma, micropapillary DCIS, and invasive carcinoma. Other etiologies included mucinous carcinoma and cystic lesions, with only 1 case in which a mechanism for DE could not be postulated.

scholarly journals A retrospective observational study of intraductal breast papilloma and its coexisting lesions: a real-world experience

2019 ◽  
Author(s):  
Xiaoyun Mao ◽  
Huan Wang ◽  
Zhe Sun ◽  
Chuifeng Fan ◽  
Feng Jin
Keyword(s):  
Real World ◽  
Chinese Women ◽  
Nipple Discharge ◽  
Clinical Manifestations ◽  
Clinical Information ◽  
Intraductal Papilloma ◽  
Breast Mass ◽  
Benign Lesions ◽  
Palpable Mass ◽  
Palpable Breast

Abstract Background: Breast intraductal papilloma are a heterogeneous group. The aim of this study is to investigate the intraductal breast papilloma and its coexisting lesions retrospectively in real-world practice. Methods: We retrospectively identified 4450 intraductal breast papilloma and its coexisting lesions. Results: 18.36% coexisted with malignant lesions of the breast, 37.33% coexisted with atypia hyperplasia, 25.24% coexisted with benign lesions and only 19.10% coexisted without concomitant lesions. In addition, 36.80% of intraductal breast papilloma had nipple discharge, 51.46% had a palpable breast mass and 16.45% had both nipple discharge and a palpable breast mass. 28.18% experienced discomfort or were asymptomatic. Furthermore, 98.99% had ultrasound abnormalities, 53.06% had intraductal hypoechoic upon ultrasound. 31.89% had mammographic distortion, 14.45% had microcalcification upon mammography. Intraductal breast papilloma with malignancy had significant correlations with clinical manifestations. Conclusion: Coexisting malignancy was also related to ultrasound abnormality (BIRADS 4C and 5), mammographic distortion and microcalcification upon mammography but was not related to the intraductal hypoechoic upon ultrasound. Coexisting atypical hyperplasia correlated with nipple discharge but not palpable mass, mammographic distortion or intraductal hypoechoic upon ultrasound. The coexisting atypia hyperplasia was also related to abnormality upon ultrasound or microcalcification compared with the benign lesions. The intraductal papilloma coexists with malignancy or atypia hyperplasia accounted for more than 50%, the clinical information on papilloma and its coexisting lesions is nonspecific. We recommended surgical treatment for benign intraductal papillary lesions. Impact: The current study provides insight into the real-world pattern of intraductal papillomas and their coexisting lesions in a population of Chinese women.

F.N.A.C. AS DIAGNOSTIC TOOL OF PAROTID TUMORS AND ASSOCIATED PITFALLS IN CORRELATION WITH HISTOPATHOLOGY

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Bhawana Pant ◽  
Sanjay Gaur ◽  
Prabhat Pant
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Clinical Information ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cytological Diagnosis ◽  
Tertiary Referral Centre ◽  
Clear Cut ◽  
Parotid Tumors

F.NA.C has been used for ages as a safe and economical tool for fast preoperative diagnosis of parotid tumors. It has certain pitfall which sometimes leads to misdiagnosis and consequently it may have affect on treatment of the tumors. Keeping in view of the diverse classification of parotid tumors’ information from cytology should be combined with radiology as well as clinical diagnosis. Aim: To discuss some cases where there was discrepancy between cytological diagnosis and histopathological result and also suggest measures to improve the efficacy of F.N.A.C. Material and methods: The study includes 50 cases of parotid tumours who presented to the  department of ENT at Government medical college Haldwani which is a tertiary referral centre during 2009 to 2016. Only adult patients were included and inflammatory swelling were excluded from the study. All patients evaluated  Contrast enhanced computerized tomography(CECT) and  Magnetic resonance imaging (MRI) followed by Fine needle aspiration cytology .Preoperative diagnosis was made upon the findings of the above investigations and different types of  parotid surgeries  were done. . Final diagnosis was made on  histopathological  examination. Result :The most common tumour  came out to be pleomorphic adenoma (23 cases-46%) followed by mucoepidermoid carcinoma(12cases-24%). In ten  cases there was no clear cut  association between cytological diagnosis and final histopathological diagnosis. Conclusion: FNAC is highly sensitive and specific technique for diagnosis of many salivary gland swellings. FNAC can be used preoperatively to avoid unnecessary surgery and biopsy. Details of clinical information and radiologic features may help the pathologist to arrive at the appropriate diagnosis and reduce false interpretation. Pitfalls may also occur with improper technique of FNAC which can be overcome by proper caution.

scholarly journals Pulmonary adenocarcinoma in cattle

2014 ◽  
pp. 4358-4363 ◽  
Author(s):  
Diogo Sousa Z ◽  
Luis Rivera C ◽  
Didier Quevedo C ◽  
Ana Claudia Gorino ◽  
Simone Biagio C ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tumor Cells ◽  
Adult Female ◽  
Histopathological Examination ◽  
Abdominal Cavity ◽  
Pulmonary Adenocarcinoma ◽  
Immunohistochemical Examination ◽  
Histopathological Findings ◽  
Hematoxylin Eosin ◽  
Neoplastic Epithelial Cells

ABSTRACTThe Macroscopic, histological and immunohistochemical aspects of lung acinar adenocarcinoma and the presence of nodules in the abdominal cavity of an adult female bovine are reported. In the necropsy analysis samples were collected from the: lung, heart, spleen, liver, pancreas, kidney, uterus, intestine, brain, and from nodules found in the lung and abdominal cavity, which were routinely processed to be stained by hematoxylin-eosin and for an immunohistochemistry exam with the antibodies: cytokeratin (dilution 1:200 μL) and vimentin (dilution 1:1000 μL). The histopathological examination revealed neoplastic epithelial cells with acini formation. The immunohistochemical examination of the tumor cells showed positive marking for cytokeratin and the absence of marking for vimentin. According to anatomical, morphological, and histopathological findings, as well as the result of the immunohistochemical examination, the tumor was characterized as lung acinar adenocarcinoma.

Large breast lump with bloody nipple discharge: benign intraductal papilloma

2020 ◽  
Vol 13 (11) ◽  
pp. e236818
Author(s):  
Sin Dee Cheah ◽  
Abdul Hadi Imi Sairi
Keyword(s):  
Nipple Discharge ◽  
Large Mass ◽  
Left Breast ◽  
Intraductal Papilloma ◽  
Breast Lump ◽  
Core Needle ◽  
Bloody Nipple Discharge ◽  
Uncommon Presentation ◽  
Large Breast ◽  
Benign Papilloma

A 32-year-old woman presented with a 3 cm×3 cm left breast lump associated with bloody nipple discharge during her early pregnancy. Examination and ultrasonography showed benign features, whereas core needle biopsies revealed a benign papilloma. Six months after her delivery, a 6 cm×6 cm benign papilloma was completely excised via circumareolar incision. The majority of intraductal papillomas are small; however, they can also present as a large mass rarely. We should be wary of a malignant papillary lesion when there is the presence of atypia on core needle biopsy or imaging-histology discordance. A concordant benign papilloma with benign imaging findings is otherwise reassuring. Clinicians need to be aware of this uncommon presentation of large intraductal papilloma as a complete curative excision can be achieved through a cosmetically placed incision.

Criteria of Clinical and Radiological Diagnosis in Nonpuerperal Acute Phlogistic-Like Processes of the Breast: Considerations on 97 Consecutive Cases

1981 ◽  
Vol 67 (1) ◽  
pp. 31-34
Author(s):  
Gaetano Cardona ◽  
Stefano Ciatto
Keyword(s):  
Differential Diagnosis ◽  
Diagnostic Criteria ◽  
False Positive ◽  
Nipple Discharge ◽  
Needle Aspiration ◽  
Radiological Examination ◽  
Radiological Diagnosis ◽  
Cytological Examination ◽  
Outer Quadrant ◽  
Radiological Evidence

The authors report a series of 97 cases of phlogistic-like process of the breast. Clinical and radiological signs and criteria of differential diagnosis between benign phlogosis and cancer are investigated. The location in the areolar/periareolar region, the presence of fever, and the radiological evidence of limited skin thickening were the features more significantly correlated with benign phlogosis, while cancer should be suspected in the case of lesions located in the upper-outer quadrant and in presence of a diffuse skin thickening at radiological examination. These diagnostic criteria seem particularly useful since the typical clinical or radiological signs of cancer are present only in 50 % of cancer cases. The cytological examination of nipple discharge or needle aspiration fluid is of particular help: no false positive or negative cases were observed in a series of 42 examined patients.

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