F.N.A.C. AS DIAGNOSTIC TOOL OF PAROTID TUMORS AND ASSOCIATED PITFALLS IN CORRELATION WITH HISTOPATHOLOGY

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Bhawana Pant ◽  
Sanjay Gaur ◽  
Prabhat Pant
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Clinical Information ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cytological Diagnosis ◽  
Tertiary Referral Centre ◽  
Clear Cut ◽  
Parotid Tumors

F.NA.C has been used for ages as a safe and economical tool for fast preoperative diagnosis of parotid tumors. It has certain pitfall which sometimes leads to misdiagnosis and consequently it may have affect on treatment of the tumors. Keeping in view of the diverse classification of parotid tumors’ information from cytology should be combined with radiology as well as clinical diagnosis. Aim: To discuss some cases where there was discrepancy between cytological diagnosis and histopathological result and also suggest measures to improve the efficacy of F.N.A.C. Material and methods: The study includes 50 cases of parotid tumours who presented to the  department of ENT at Government medical college Haldwani which is a tertiary referral centre during 2009 to 2016. Only adult patients were included and inflammatory swelling were excluded from the study. All patients evaluated  Contrast enhanced computerized tomography(CECT) and  Magnetic resonance imaging (MRI) followed by Fine needle aspiration cytology .Preoperative diagnosis was made upon the findings of the above investigations and different types of  parotid surgeries  were done. . Final diagnosis was made on  histopathological  examination. Result :The most common tumour  came out to be pleomorphic adenoma (23 cases-46%) followed by mucoepidermoid carcinoma(12cases-24%). In ten  cases there was no clear cut  association between cytological diagnosis and final histopathological diagnosis. Conclusion: FNAC is highly sensitive and specific technique for diagnosis of many salivary gland swellings. FNAC can be used preoperatively to avoid unnecessary surgery and biopsy. Details of clinical information and radiologic features may help the pathologist to arrive at the appropriate diagnosis and reduce false interpretation. Pitfalls may also occur with improper technique of FNAC which can be overcome by proper caution.

scholarly journals Clinicopathological and Radiological Profile of Multinodular Goitre – A Prospective Study

2021 ◽  
Vol 29 (2) ◽  
pp. 164-168
Author(s):  
Koustav Mondal ◽  
Chiranjib Das
Keyword(s):  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Multinodular Goitre ◽  
Sensitivity Specificity

Introduction Multinodular goitre (MNG) is defined as multiple palpable distinct nodules in the enlarged thyroid gland. MNG can harbour malignancy in 1-10% cases. We undertook the present study to correlate the clinical, radiological and cytological features of MNG with that of final histopathological diagnosis. Materials and Methods A prospective cohort study was done in a tertiary care hospital in northern part of West Bengal from January 2018 to December 2019. Patients aged between 12 years and 75 years, presenting with MNG on clinical examination, were included in the study. We compared the pre-operative ultrasonography (USG) of neck and fine needle aspiration cytology (FNAC) reports with post-operative histopathological examination (HPE) report. Results Among 100 patients 80 were female and 20 were male. Most patients were in 41-50 years age group. For detection of malignancy in MNG, USG had 40% sensitivity, 97.78% specificity, 66.67% positive predictive value (PPV), 93.62% negative predictive value (NPV), and 92% diagnostic accuracy. Sensitivity, specificity, PPV, NPV and diagnostic accuracy of FNAC for detection of malignancy in MNG were 20%, 93.33%, 25%, 91.3% and 86% respectively. When USG features were combined with FNAC features non-diagnostic result decreased from 6% to 2% and diagnostic accuracy for detecting malignancy in MNG increased from 86% to 90%. Conclusion USG and FNAC are complementary to each other in the diagnostic workup of MNG. USG guided FNAC is still better for reaching final diagnosis and exclusion of malignancy.

scholarly journals Correlation of FNAC and histopathology in diagnosis of salivary gland lesions

2014 ◽  
Vol 4 (8) ◽  
pp. 654-657 ◽  
Author(s):  
S Koirala ◽  
G Sayami ◽  
AD Pant
Keyword(s):  
Salivary Gland ◽  
Preoperative Diagnosis ◽  
Needle Aspiration ◽  
University Teaching ◽  
Malignant Neoplasms ◽  
Histopathological Diagnosis ◽  
Institute Of Medicine ◽  
Needle Aspiration Cytology ◽  
Sensitivity Specificity ◽  
Diagnostic Pitfalls

Background: Value of fine needle aspiration cytology in preoperative diagnosis of salivary gland lumps has been established in various studies. This study aims to calculate sensitivity, specificity accuracy of FNAC, correlate FNAC findings with histopathology and find out reasons for common diagnostic pitfalls in FNAC.Materials and methods: This study was performed in 67 patients that presented with salivary gland lumps at Department of pathology, Tribhuvan University Teaching Hospital, Institute of medicine, Kathmandu, Nepal from January 2009 to June 2010. FNAC was performed and was correlated with histopathological diagnosis to judge the sensitivity, specificity and accuracy of FNAC.Results: Out of 36 cases there was cyto-histological correlation in 28 cases. Pleomorphic adenoma was the most frequent lesion in this study. Parotid gland was the most common site affected by salivary gland lesions. The sensitivity, specificity and accuracy for non-neoplastic lesions was 100%, 89.28%, 91.67%, for benign neoplasms was 100%, 86.95%, 91.67% and for malignant neoplasms was 57.14%, 100%, 83.33% respectively.Conclusion: FNAC is a useful tool in preoperative diagnosis of salivary gland lesions and can be crucial for the management of the patient. Aspiration and reporting of salivary gland lesions demands a competent pathologist who considers all the possible diagnostic pitfalls in mind.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11593 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 654-657

Neurilemmomas of the Facial Nerve Presenting as Parotid Tumors

1984 ◽  
Vol 93 (1) ◽  
pp. 70-72 ◽  
Author(s):  
Viggo H. Balle ◽  
Ole Greisen
Keyword(s):  
Facial Nerve ◽  
Preoperative Diagnosis ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Nerve Grafting ◽  
True Nature ◽  
Fine Needle ◽  
Parotid Tumors ◽  
Correct Preoperative Diagnosis ◽  
Facial Function

Two cases of rare benign facial neurilemmomas are presented. In both cases the only complaint was a parotid mass and both patients had normal facial function. The true nature of the tumors was not discovered before operation. Repeated fine-needle aspiration biopsy did not contribute to a correct preoperative diagnosis. In both instances the facial nerve had to be sacrificed and free autogenous nerve grafting was done.

scholarly journals A prospective study and correlation of cytological, cell-block and histopathological diagnosis of breast lesions

2021 ◽  
Vol 8 (3) ◽  
pp. 352-358
Author(s):  
Ankita Paul ◽  
Sowmya S Manjunath
Keyword(s):  
Prospective Study ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cell Block ◽  
Diagnostic Modality ◽  
Cross Sectional ◽  
Diagnostic Role ◽  
Palpable Breast ◽  
A Prospective Study

Breast carcinoma is the second most common cancer in the world and establishing an early diagnosis is clinically very important. Fine needle aspiration cytology (FNAC) is the fast, reliable and ideal initial diagnostic modality for the diagnosis of these lesions. This is a cross-sectional prospective study of 12 months duration. A total of 160 patients underwent FNAC of palpable breast lump/lumps. A cell-block preparation was done for 80 cases and the histopathological examination has been performed on all the 160 cases.The cytomorphological diagnosis, cell-block diagnosis and histopathological diagnosis were correlated using suitable statistical methods. Out of 160 patients, on cytological examination, 107 cases (67%) were benign and 53cases (33%) were malignant. On histopathological examination, 104 cases (65%) were benign and 56 cases (35%) were malignant. On examination of cell block, two cases which were indeterminate in FNAC turned out to be malignant. FNAC plays a main diagnostic role as an out-patient procedure which gives rapid diagnosis. FNAC when combined with cell-block can give more accurate diagnosis.

scholarly journals The role of immunohistochemical evaluation in the diagnosis of malignant mesothelioma of the pleura

2013 ◽  
Vol 70 (11) ◽  
pp. 1010-1014 ◽  
Author(s):  
Milana Panjkovic ◽  
Aleksandra Lovrenski ◽  
Zivka Eri ◽  
Slavica Knezevic-Usaj ◽  
Dragana Tegeltija ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Diagnostic Procedure ◽  
Histopathological Examination ◽  
Immunohistochemical Analysis ◽  
Final Diagnosis ◽  
Histopathological Diagnosis ◽  
Pleural Mesothelioma ◽  
Made In

Backround/Aim. The final diagnosis of malignant pleural mesothelioma is made exclusively by histopathological examination of biopsy materials that are routinely complemented by the use of immunohistochemical analysis. The aim of this paper was to determine the significance of immunohistochemical analysis and application of certain antibodies in the diagnosis of malignant pleural mesothelioma. Methods. This retrospective analysis included clinical data of 32 patients with the histopathological diagnosis of malignant pleural mesothelioma made in the period 2004-2009 at the Institute for Pulmonary Diseases in Sremska Kamenica. The material was processed and analyzed at the Center for Pathology. Results. CK5/6 was positive, in 63% of the cases calretinin, in 94% and HBME-1 in 80% of the cases. CK7 was positive in 78%, and EMA in 83% of the cases. All the cases (100%) were negative for TTF-1, CEA, CD20, desmin and MOC31. Conclusion. Immunohistochemistry has become an essential diagnostic procedure for the diagnosis and determination of the type of malignant pleural mesothelioma, and due to the lack of individual antibodies a combination of antibody with different sensitivity and specificity is in use today.

Diagnostic Evaluation of Skin Adnexal Tumors by Fine-Needle Aspiration Cytology

2016 ◽  
Vol 60 (3) ◽  
pp. 246-253 ◽  
Author(s):  
Priyanka Chand ◽  
Pratima Khare ◽  
Renu Gupta ◽  
Sonam Kumar Pruthi ◽  
Mukta Ahuja ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Partial Correlation ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Adnexal Tumor ◽  
Needle Aspiration Cytology ◽  
Adnexal Tumors

Background: The diagnosis of skin adnexal tumors is usually based on histopathology. However, fine-needle aspiration cytology (FNAC) can be of great help and shows a high degree of correlation to the final diagnosis. It is helpful in many situations where skin lesions are a manifestation of certain systemic syndromes and aids to the formation of precise treatment plans. Materials and Methods: This prospective study was carried out to assess the diagnosis of skin adnexal tumors based on FNAC and their comparison with histopathological diagnoses. There were 14 patients with FNAC and histopathological follow-up in whom a final diagnosis of skin adnexal tumor was made. The results of FNAC were compared with histopathological diagnoses for complete correlation, partial correlation (cases where an FNAC diagnosis of skin adnexal tumor was made but a precise diagnosis of the subtype was not possible) or no correlation (where FNAC failed to diagnose a skin adnexal tumor). Results: Among the 14 cases of skin adnexal tumor, there was total correlation between the FNAC diagnosis and final histopathological diagnosis in 8 cases (57.1%) and a partial correlation in 4 cases (28.5%). There was no correlation of the FNAC diagnosis with the histopathological diagnosis in only 2 cases (14.3%). Conclusions: FNAC is very useful in making a diagnosis of skin adnexal tumors and helps in the management of the patient.

scholarly journals Multicenter Study on the Diagnostic of Imaging Tests and EUS-guided fine needle aspiration of Solid Pseudopapillary Neoplasms of the Pancreas

2021 ◽  
Author(s):  
Vítor Doria Ricardo ◽  
Giulia Marchetti ◽  
Arthur Ferraz de Almeida ◽  
César Vivian Lopes ◽  
Jerusa Santos dos Reis ◽  
...  
Keyword(s):  
Preoperative Diagnosis ◽  
Demographic Data ◽  
Correct Diagnosis ◽  
High Volume ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Common Symptom ◽  
Surgical Specimen ◽  
Mean Size ◽  
Ct And Mri

Abstract Purpose Imaging diagnosis of SPN is difficult. Preoperative diagnosis by EUS-FNA) is possible, safe, and has been reported in the literature. However, its usefulness is still controversial. The aim of this study was to determine the accuracy of the EUS-FNA and imaging findings in CT and MRI/MRCP exams in the diagnosis of patients with SPN. Methods We retrospectively reviewed the medical records of patients undergoing EUS-FNA with suspected diagnosis of SPN on imaging studies in 5 high-volume hospitals. The final diagnosis was obtained after the histological examination of the surgical specimen. Demographic data, CT, MRI and EUS findings, anatomopathological specimen and McH results obtained by EUS were analyzed. Results Fifty-four patients were included, of which 49 (90.7%) were women with an average age of 33.4 (range 11–78) years. The most common symptom presented was abdominal pain, present in 35.2%. SPN was detected incidentally in 32 (59%). The mean size of the tumors was 3.8 cm (SD: 2.26). The most common findings at EUS were a solid, solid/cystic, and cystic lesion in 52.9%, 41.1% and 7.8%, respectively. The final diagnosis was SPN in 51 patients and NF-NET in 3. The correct diagnosis was made by CT, MRI, EUS and EUS-FNA in 21.9%, 28.9%, 64.7% and 88.2%, respectively. EUS-FNA associated with CT and MRI increased diagnostic performance to 94.11% and 94.11%, respectively. Conclusion Differential diagnosis between SPN and NF-NET with imaging tests can be difficult. EUS-FNA increases preoperative diagnosis in such cases and should be routinely used to rule out NF-NET.

scholarly journals Comparative study of aspiration versus non-aspiration fine needle technique in thyroid nodule and its correlation with post-operative histopathological examination

2018 ◽  
Vol 5 (3) ◽  
pp. 1046
Author(s):  
Harish Kumar C. ◽  
Yaam Kumar C.
Keyword(s):  
Thyroid Nodule ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
Cytological Diagnosis ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Cellular Architecture ◽  
Glass Slides ◽  
Needle Technique ◽  
Needle Aspiration Cytology

Background: Thyroid gland is unique of all endocrine glands because it is the largest, superficial and the only one amendable to direct physical examination. A discrete swelling in one lobe and with no palpable abnormality elsewhere is termed as solitary swelling. Fine needle aspiration cytology (FNAC) is the investigation of choice in solitary thyroid swellings. There is another technique fine needle non aspiration cytology (FNNAC) which avoids aspiration but still permits cytologic review of the swellings which can also be done in thyroid swellings. The objective of the study was to compare and analyze the preoperative efficiency of FNAC vs FNNAC in solitary thyroid nodules and its correlation with post-operative histopathological examination findings.Methods: A total of 72 patients presenting with thyroid nodule in this hospital in BMCRI, Bengaluru during period of January2017 to December2017 underwent both FNAC and techniques. 23 G needles was used for both FNAC and FNNAC. FNAC was performed using needle and a syringe using aspiration. In FNNAC technique the needle held between thumb and fore finger of one hand was gently inserted into the nodule and was moved in different directions. Material entering the needle hub by capillary action was then expressed onto clean glass slides after attaching syringe filled with air to it and smears were prepared. Cases which underwent total/hemi thyroidectomy, the specimen was sent to pathology department in 10% formalin solution.Results: FNNAC produced diagnostically superior samples and less diagnostically inadequate samples than FNAC.Conclusions: As thyroid is a vascular and a colloid organ, in FNAC aspiration gives blood/colloid with less cellular architecture in most of the cases. In FNNAC cellular architecture was preserved with less blood/colloid background which aids in easier cytological diagnosis. Hence FNNAC is a better technique than FNAC in cytological diagnosis of solitary thyroid nodule.

scholarly journals Accuracy Of Fine Needle Aspiration Cytology (FNAC) In The Diagnosis Of Thyroid Swellings

2013 ◽  
Vol 18 (2) ◽  
pp. 47-51 ◽  
Author(s):  
Md Alamgir Hossain Sikder ◽  
AZM Mahfuzur Rahman ◽  
Md Abul Khair
Keyword(s):  
Thyroid Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Aspiration Cytology ◽  
Female Ratio ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Objective: To evaluate the accuracy of fine needle aspiration cytology (FNAC) in comparison to paraffin section in thyroid swelling. Study design: Cross sectional study. Place and duration of study: Department of Surgery, Bangabandhu Sheikh Mujib Medical University from July 2009 to June 2011. Patient and method: One hundred patients with enlarged thyroid gland of both sexes were selected from admitted patient of Surgery department. All patients had preoperative FNAC, performed by pathologist at the Histopathology department and postoperative specimen were also examined and histopathological diagnosis were made. All FNAC diagnosis were correlated with the histopathological diagnosis. Results: Out of 100 patients 23 were male and 77 were female, male-female ratio 1: 3.3. In FNAC 76 patients were diagnosed as benign lesion of which 8 were later diagnosed as malignant on histopathological examination (68 were true negative 8 were false negative). 22 cases were diagnosed as malignant, both on FNAC and histopathological examination. Only 2 cases were diagnosed as follicular neoplasm on FNAC but on histopathological examination diagnosed as follicular carcinoma (22 cases were true positive) in this study. Overall sensitivity of FNAC were 68.75%, specificity 100.00% and accuracy 90%; PPV=100% & NPV=87.18% Conclusion: FNAC is a reliable, safe and accurate method as a preoperative evaluation in thyroid gland swelling before surgery. FNAC has more accuracy and specificity in detecting thyroid gland malignancy and therefore it is a reliable diagnostic test for evaluating thyroid swellings. DOI: http://dx.doi.org/10.3329/jdnmch.v18i2.16023 J. Dhaka National Med. Coll. Hos. 2012; 18 (02): 47-51

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