In Vivo Optical Coherence Tomography: The Role of the Pathologist

2012 ◽  
Vol 136 (12) ◽  
pp. 1492-1501 ◽  
Author(s):  
Lida P. Hariri ◽  
Mari Mino-Kenudson ◽  
Eugene J. Mark ◽  
Melissa J. Suter
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Frequency Domain ◽  
Sampling Error ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Optical Frequency ◽  
Optical Coherence ◽  
Optical Frequency Domain Imaging

Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology.

Zero-crossing approach to high-resolution reconstruction in frequency-domain optical-coherence tomography

2012 ◽  
Vol 29 (10) ◽  
pp. 2080 ◽  
Author(s):  
Sunder Ram Krishnan ◽  
Chandra Sekhar Seelamantula ◽  
Arno Bouwens ◽  
Marcel Leutenegger ◽  
Theo Lasser
Keyword(s):  
Optical Coherence Tomography ◽  
High Resolution ◽  
Frequency Domain ◽  
Optical Coherence ◽  
Zero Crossing ◽  
High Resolution Reconstruction

scholarly journals Modern Trends in Imaging V: Optical Coherence Tomography for Rapid Tissue Screening and Directed Histological Sectioning

2012 ◽  
Vol 35 (3) ◽  
pp. 129-143 ◽  
Author(s):  
Woonggyu Jung ◽  
Stephen A. Boppart
Keyword(s):  
Optical Coherence Tomography ◽  
Real Time ◽  
Image Guidance ◽  
Diagnostic Yield ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Optical Coherence ◽  
Sampling Errors ◽  
Cross Sectional

In pathology, histological examination of the “gold standard” to diagnose various diseases. It has contributed significantly toward identifying the abnormalities in tissues and cells, but has inherent drawbacks when used for fast and accurate diagnosis. These limitations include the lack ofin vivoobservation in real time and sampling errors due to limited number and area coverage of tissue sections. Its diagnostic yield also varies depending on the ability of the physician and the effectiveness of any image guidance technique that may be used for tissue screening during excisional biopsy. In order to overcome these current limitations of histology-based diagnostics, there are significant needs for either complementary or alternative imaging techniques which perform non-destructive, high resolution, and rapid tissue screening. Optical coherence tomography (OCT) is an emerging imaging modality which allows real-time cross-sectional imaging with high resolutions that approach those of histology. OCT could be a very promising technique which has the potential to be used as an adjunct to histological tissue observation when it is not practical to take specimens for histological processing, when large areas of tissue need investigating, or when rapid microscopic imaging is needed. This review will describe the use of OCT as an image guidance tool for fast tissue screening and directed histological tissue sectioning in pathology.

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