scholarly journals Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls

2019 ◽  
Vol 143 (1) ◽  
pp. 47-64 ◽  
Author(s):  
Natalia Buza
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Ovarian Carcinomas ◽  
Intraoperative Frozen Section ◽  
Epithelial Tumors ◽  
Ovarian Epithelial Tumors ◽  
Wide Range ◽  
Frozen Section Diagnosis ◽  
Section Evaluation

Context.— Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Therefore, intraoperative frozen section evaluation is crucial for determining the required extent of surgery, that is, cystectomy for benign tumors, oophorectomy or limited surgical staging for borderline tumors in younger patients to preserve fertility, or extensive staging procedure for ovarian carcinomas. Ovarian epithelial tumors may exhibit a wide range of morphologic patterns, which often overlap with each other and can mimic a variety of other ovarian nonepithelial neoplasms as well. A combination of careful gross examination, appropriate sampling and interpretation of morphologic findings, and familiarity with the clinical context is the key to the accurate frozen section diagnosis and successful intraoperative consultation. Objective.— To review the salient frozen section diagnostic features of ovarian epithelial tumors, with special emphasis on useful clinicopathologic and morphologic clues and potential diagnostic pitfalls. Data Sources.— Review of the literature and personal experience of the author. Conclusions.— Frozen section evaluation of ovarian tumors continues to pose a significant diagnostic challenge for practicing pathologists. This review article presents detailed discussions of the most common clinical scenarios and diagnostic problems encountered during intraoperative frozen section evaluation of mucinous, serous, endometrioid, and clear cell ovarian tumors.

scholarly journals Role of intraoperative frozen section in the diagnosis of ovarian tumors: Experience at Gujarat Cancer and Research Institute

2016 ◽  
Author(s):  
Ruchi Arora
Keyword(s):  
Surgical Management ◽  
Ovarian Neoplasms ◽  
Frozen Section ◽  
Ovarian Tumors ◽  
Borderline Tumors ◽  
Intraoperative Frozen Section ◽  
Histopathologic Diagnosis ◽  
Frozen Section Diagnosis ◽  
Line Of Therapy

Background: The surgical management of ovarian tumors depends on their correct categorization as benign, borderline or malignant. Ovarian neoplasms are an important cause of morbidity and mortality in women. This study was undertaken to evaluate the accuracy of intra-operative frozen section in the diagnosis of various categories of ovarian neoplasms. Methods: Intraoperative frozen section diagnosis was retrospectively evaluated in 125 patients with suspected ovarian neoplasms who underwent surgery as primary line of therapy at our institution. This was compared with the final histopathologic diagnosis on paraffin sections. Results: In 125 patients frozen section report had a sensitivity of 100%, 95.55% and 50% for benign, malignant and borderline tumors respectively. The corresponding specificities were 92.45%, 98.75% and 99.14% respectively. The overall accuracy of frozen section diagnosis was 95.2%. The majority of cases of disagreement were in the mucinous and borderline tumors. Conclusion: Intraoperative frozen section has high accuracy in the diagnosis of suspected ovarian neoplasms. It is a valuable tool to guide the surgical management of these patients and should be routinely used in all major oncology centers.

scholarly journals Osteopontin as a Prognostic Indicator in Grading of Ovarian Epithelial Tumors

2015 ◽  
Vol 7 (2) ◽  
pp. 61-63
Author(s):  
Ganga S Pilli ◽  
Prakash V Patil ◽  
SG Karadesai
Keyword(s):  
Prognostic Indicator ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
P Value ◽  
Low Grade ◽  
High Grade ◽  
Osteopontin Expression ◽  
Epithelial Tumors ◽  
Ovarian Epithelial Tumors ◽  
Ovarian Cancers

ABSTRACT Aim To determine if osteopontin expression by immunohistochemistry (IHC) can correlate with histological type and grade of epithelial ovarian cancer. Materials and methods The present work has been carried out at department of pathology, of a reputed medical college in Belgaum district of Karnataka state. The study is carried out for a period of 18 months for data collection, evaluation of the marker and data analysis. All consecutive specimens of ovarian tumors are included in the study. The study included 55 epithelial ovarian tumors and these are analyzed histopathologically. In all the cases, osteopontin expression has been studied with IHC on paraffin slides. Results This study included 41 (74.5%) benign tumors and 14 (25.5%) malignant tumors. High grade (grade III) was common in serous carcinomas than in other histological types. Fisher's exact test p-value < 0.001 was significant for expression of osteopontin and all the malignant ovarian epithelial tumors expressed osteopontin by IHC procedure on paraffin tissue sections. All high-grade epithelial ovarian tumors showed increased expression of osteopontin of +++ and low-grade tumors expressed +/++osteopontin. Conclusion The osteopontin expression was seen in all the malignant epithelial ovarian cancers and the osteopontin expression was significantly higher in high-grade epithelial ovarian cancers than low-grade epithelial ovarian cancers. How to cite this article Pilli GS, Patil PV, Karadesai SG. Osteopontin as a Prognostic Indicator in Grading of Ovarian Epithelial Tumors. J South Asian Feder Obst Gynae 2015;7(2): 61-63.

scholarly journals Accuracy of Intraoperative Frozen Section Diagnosis of Borderline Ovarian Tumors by Hospital Type

2019 ◽  
Vol 26 (1) ◽  
pp. 87-93 ◽  
Author(s):  
Jaimin S. Shah ◽  
Michael Mackelvie ◽  
David M. Gershenson ◽  
Preetha Ramalingam ◽  
Marylee M. Kott ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Hospital Type ◽  
Intraoperative Frozen Section ◽  
Borderline Ovarian Tumors ◽  
Frozen Section Diagnosis

Accuracy of Intraoperative Frozen Section Diagnosis of Ovarian Tumors

2001 ◽  
Vol 81 (2) ◽  
pp. 230-232 ◽  
Author(s):  
Paola B.C. Pinto ◽  
Liliana A.L.A. Andrade ◽  
Sophie F.M. Derchain
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Intraoperative Frozen Section ◽  
Frozen Section Diagnosis

Does Intraoperative Frozen Section Diagnosis Correlate with Final Pathology in Borderline Ovarian Tumors

2017 ◽  
Vol 147 (1) ◽  
pp. 217-218
Author(s):  
J. Shah ◽  
M. Mackelvie ◽  
P. Ramalingam ◽  
P. Gauthier ◽  
M. Kott ◽  
...  
Keyword(s):  
Frozen Section ◽  
Ovarian Tumors ◽  
Final Pathology ◽  
Intraoperative Frozen Section ◽  
Borderline Ovarian Tumors ◽  
Frozen Section Diagnosis

scholarly journals Role of CA 19-9 in complex ovarian tumors

2016 ◽  
Author(s):  
Dhanya S. Thomas ◽  
Ajit Sebastian ◽  
Vinotha Thomas ◽  
Anitha Thomas ◽  
Rachel Chandy ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Ovarian Mass ◽  
Radiological Findings ◽  
Epithelial Tumors ◽  
Mucin Glycoprotein ◽  
Glycoprotein Antigen ◽  
Mucinous Tumours

Background: Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that may be elevated in healthy individuals as well as in patients with benign and malignant tumors. It is useful in the management of pancreatic and other gastrointestinal tumors. CA 19-9 is also elevated in benign and malignant ovarian tumors. Aim: To study the pattern of serum CA19-9 in complex ovarian tumors. Methods: The study design was descriptive, based on data collected from medical records. Patients with a complex ovarian mass, who were investigated with CA 19-9 and had undergone surgery, wereincluded in the study. The study duration was 2 years from January 2014 to December 2015. A total of 273 patients (119 - benign and 154 malignant) with complex ovarian mass and elevated CA 19-9 underwent surgery during the study period. Results: CA 19-9 was elevated in 55 patients (20%). Of these, 23 patients had benign tumors while 32 had malignant tumors.Among patients with benign tumors, 21 had dermoid, 23 had mucinous tumors and 75 had other types of tumors. CA 19-9 was elevated in 10 (47.6%) of the dermoids, 7 (30.4%) of the mucinous tumors and 6 (8%) of the other benign tumors. Among patients with malignant tumors, 138 were epithelial and 16 were non epithelial tumors. Of the epithelial tumors, 31 were mucinous and 107 were non mucinous types. Overall, 29 (21%) had elevated CA 19-9. Of the epithelial tumors, 22.6% of the mucinous type and 20.6% of the non mucinous type had elevated CA 19-9. Among the non-epithelial tumors, 3 (18.8%) had elevated CA19-9. Conclusion: CA 19-9 is elevated in several conditions but most likely to be raised in dermoid cysts and mucinous tumours. CA19-9 levels need to be interpreted along with clinical and radiological findings.

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

2013 ◽  
Vol 3 (5) ◽  
pp. 397-402 ◽  
Author(s):  
D Ghartimagar ◽  
A Ghosh ◽  
G KC ◽  
S Ranabhat ◽  
OP Talwar
Keyword(s):  
Ovarian Cancer ◽  
Malignant Tumors ◽  
Data Bank ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Tertiary Referral ◽  
Tertiary Referral Hospital ◽  
Tertiary Referral Centre ◽  
Epithelial Tumors

Background: Ovarian cancer accounts for 3% of all cancers in females. About 80% of these are benign, and they occur mostly in young women between 20 and 45 years. Borderline tumors occur at slightly older ages while incidence of malignant tumors increases with age, occurring predominantly in perimenopausal and postmenopausal women. About 190,000 new cases and 114,000 deaths from ovarian cancer are estimated to occur annually worldwide. The aim of the study was to fi nd the incidence of surface ovarian tumor in a tertiary referral centre. Materials and methods: This was a retrospective study carried out in the department of pathology, Manipal Teaching Hospital from January 2001 to December 2012. Specimens were received from the same and other hospitals. Records were retrieved from the departmental data bank and were analyzed. Results: : A total of 310 cases of ovarian tumors have been reported in the same period. Among them, 180 cases were of surface epithelial origin and out of which 24 cases had bilateral tumors. Benign tumors comprised of 148 cases, 6 were borderline and 44 were malignant. Among these, the commonest was serous cystadenoma (98 cases) and the least common was malignant Brenner (2 cases). Combined or mixed tumor was seen in 9 cases. Conclusion: : In our study surface epithelial tumors comprised 58% of all ovarian tumors. In both benign and malignant cases, serous tumor was the commonest followed by mucinous tumors. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 397-402 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7868

scholarly journals Clinicopathological analysis of ovarian tumours: a 10 year retrospective study

2018 ◽  
Vol 7 (8) ◽  
pp. 3216
Author(s):  
Sahana N. Naik ◽  
Sunil Kumar K. S. ◽  
Girija B.
Keyword(s):  
Malignant Tumors ◽  
Female Genital Tract ◽  
Germ Cell Tumors ◽  
Mucinous Cystadenoma ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Age Group ◽  
Epithelial Tumors ◽  
Neoplastic Lesions

Background: Ovarian tumors account for 30% of all cancers of female genital tract which represents the sixth most common cancer and fourth leading cause of death in women. The present study was done with an objective to determine the frequency and distribution of various ovarian tumors and to study their clinical and histopathological presentations.Methods: It is a retrospective observational study of patients with ovarian tumors subjected to surgery in the department of obstetrics and gynecology, SDM College of Medical Sciences and Hospital from January 2005 to December 2015.Results: There were 642 cases comprising of 77.7% of neoplastic lesions and 22.3% of non-neoplastic lesions. Majority of the ovarian tumors (83%) were seen in the age group of 20 to 50 years. Mean age for ovarian tumors was 38 years.  Among the neoplastic lesions 84% were benign, 14.2% were malignant and 1.8% were borderline tumors. Surface epithelial tumors were the commonest tumors (60.9%) followed by germ cell tumors (12.8%).  Serous cystadenoma was the most common benign tumors (47.1%) followed by mucinous cystadenoma (18.4%). Among the ovarian malignant tumors; serous cystadenocarcinoma was the most common (4.5%) followed by mucinous cystadenocarcinoma (2.6%). Chocolate cysts were the most common among the non-neoplastic lesions (36.4%).Conclusions: Ovarian neoplastic lesions were more common than non-neoplastic lesions. Benign ovarian tumors were common in reproductive age group.  The mean age of occurrence for ovarian tumor was 38 years. The most common neoplasm was surface epithelial tumors, of which serous tumors was the commonest. Chocolate cysts were the most frequently encountered histopathological finding among the non-neoplastic lesions.

Sign in / Sign up

Export Citation Format

Share Document