First fruit: the creation of the Flavr Savr tomato and the birth of genetically engineered food

2001 ◽  
Vol 39 (02) ◽  
pp. 39-0933-39-0933
2019 ◽  
Vol 25 (6) ◽  
pp. 693-699 ◽  
Author(s):  
Margarita A. Sazonova ◽  
Anastasia I. Ryzhkova ◽  
Vasily V. Sinyov ◽  
Marina D. Sazonova ◽  
Zukhra B. Khasanova ◽  
...  

Objective: In this review article, we analyzed the literature on the creation of cultures containing mutations associated with cardiovascular diseases (CVD) using transfection, transduction and editing of the human genome. Methods: We described different methods of transfection, transduction and editing of the human genome, used in the literature. Results: We reviewed the researches in which the creation of сell cultures containing mutations was described. According to the literature, system CRISPR/Cas9 proved to be the most preferred method for editing the genome. We found rather promising and interesting a practically undeveloped direction of mitochondria transfection using a gene gun. Such a gun can direct a genetically-engineered construct containing human DNA mutations to the mitochondria using heavy metal particles. However, in human molecular genetics, the transfection method using a gene gun is unfairly forgotten and is almost never used. : Ethical problems arising from editing the human genome were also discussed in our review. We came to a conclusion that it is impossible to stop scientific and technical progress. It is important that the editing of the genome takes place under the strict control of society and does not bear dangerous consequences for humanity. To achieve this, the constant interaction of science with society, culture and business is necessary. Conclusion: he most promising methods for the creation of cell cultures containing mutations linked with cardiovascular diseases, were system CRISPR/Cas9 and the gene gun.


2000 ◽  
Vol 30 (2) ◽  
pp. 353-371 ◽  
Author(s):  
Samuel S. Epstein

An interlocking legislative complex is proposed for the control of carcinogenic and other adverse impacts of established run-away petrochemical and radionuclear technologies, with particular reference to winning the losing war against cancer. These proposals are also applicable to the poorly recognized, potentially adverse public health and environmental hazards of emerging technologies, particularly genetically engineered food production. The proposals embody fundamental democratic rights—the right to know and balanced and transparent decision making—the “Precautionary Principle,” reduction in the use of toxics, incentives for the development of safe industrial technologies, and criminal sanctions for suppression or manipulation of information.


Food Policy ◽  
2018 ◽  
Vol 78 ◽  
pp. 81-90 ◽  
Author(s):  
Jayson L. Lusk ◽  
Brandon R. McFadden ◽  
Norbert Wilson

2018 ◽  
Vol 38 (1) ◽  
pp. 459-479 ◽  
Author(s):  
Sydney E. Scott ◽  
Yoel Inbar ◽  
Christopher D. Wirz ◽  
Dominique Brossard ◽  
Paul Rozin

Genetically engineered food has had its DNA, RNA, or proteins manipulated by intentional human intervention. We provide an overview of the importance and regulation of genetically engineered food and lay attitudes toward it. We first discuss the pronaturalness context in the United States and Europe that preceded the appearance of genetically engineered food. We then review the definition, prevalence, and regulation of this type of food. Genetically engineered food is widespread in some countries, but there is great controversy worldwide among individuals, governments, and other institutions about the advisability of growing and consuming it. In general, life scientists have a much more positive view of genetically engineered food than laypeople. We examine the bases of lay opposition to genetically engineered food and the evidence for how attitudes change. Laypeople tend to see genetically engineered food as dangerous and offering few benefits. We suggest that much of the lay opposition is morally based. One possibility is that, in some contexts, people view nature and naturalness as sacred and genetically engineered food as a violation of naturalness. We also suggest that for many people these perceptions of naturalness and attitudes toward genetically engineered food follow the sympathetic magical law of contagion, in which even minimal contact between a natural food and an unnatural entity, either a scientist or a piece of foreign DNA, pollutes or contaminates the natural entity and renders it unacceptable or even immoral to consume.


Leonardo ◽  
2002 ◽  
Vol 35 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Steve Tomasula

The creation of Alba, the first mammal genetically engineered to be a work of art, accents the increasing number of artists who take as their medium plants, cells, genes and other biological materials. Like traditional artists, these bioartists raise traditional art issues; but since their work collapses the gap between art and science, representation and biological form, they also marry the rich tradition of manipulating nature for aesthetic reasons, the ethical complexities created by today's biotech revolution and the historical ramifications of applying aesthetic judgment to humans.


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