Transformations of humans through advances in bioelectronics, nanotechnologies, and computer science are leading to hybrids of humans and machines. Future brain-machine interfaces will enable humans not only to be constantly linked to the Internet, and to cyber think, but will also enable technology to take information directly from the brain. Brain-computer interfaces, where a chip is implanted in the brain, will facilitate a tremendous augmentation of human capacities, including the radical enhancement of the human ability to remember and to reason, and to achieve immortality through cloning and brain downloading, or existence in virtual reality. The ethical and legal issues raised by these possibilities represent global challenges. The most pressing concerns are those raised by privacy and autonomy. The potential exists for control of persons, through global tracking, by actually “seeing” and “hearing” what the individual is experiencing, and by controlling and directing an individual’s thoughts, emotions, moods, and motivations. Public dialogue must be initiated. New principles, agencies, and regulations need to be formulated and scientific organizations, states, countries, and the United Nations must all be involved.