Two faces of the phenolic antitumor drug etoposide (VP-16): Free radical enhancement of cytotoxicity and protection against free radical-induced DNA damage

1993 ◽  
Vol 15 (5) ◽  
pp. 493 ◽  
Author(s):  
J.C. Yalowich ◽  
H.G. Claycamp ◽  
D.A. Stoyanovsky ◽  
W. Allan ◽  
T.G. Gantchev ◽  
...  
Keyword(s):  
Dna Damage ◽  
Free Radical ◽  
Antitumor Drug ◽  
Radical Enhancement

8. Evaluation of Snow Fungus Polysaccharides on benzo[a]pyrene-induced DNA Damage

2018 ◽  
Author(s):  
Daisy Liu
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Free Radical ◽  
Radical Scavenging ◽  
Chinese Hamster ◽  
Negative Control ◽  
Lung Fibroblasts ◽  
Protective Effects ◽  
Tremella Fuciformis

Snow fungus, Tremella fuciformis, has been demonstrated to have numerous health benefits including purported chemopreventive properties due to free radical-scavenging ability. Protective effects derived from snow fungus polysaccharides are evaluated on Chinese hamster lung fibroblasts (CCL-39) exposed to carcinogen benzo[a]pyrene known to cause free radical formation and oxidative stress to cells. In this experiment, it was hypothesized that the naturally occurring polysaccharides in snow fungus are able to protect against or reduce oxidative stress-induced DNA damage. Polysaccharides were isolated through an alkaline extraction and in-vitro digestion. DNA damage was measured using the single-cell gel electrophoresis comet assay after exposure to benzo[a]pyrene and polysaccharide extract to lung fibroblasts. Results were calculated using the mean and standard deviation data of tail length and area, respectively. Each damaged cell was measured and analyzed through ImageJ Editing Software. The results indicate a promising trend which depict snow fungus polysaccharides yielding lower levels of DNA damage compared to cells exposed to benzo[a]pyrene and compared to the negative control (phosphate buffered saline and Dulbecco’s cell medium). This study suggests polysaccharides from Tremella fuciformis could truly prevent cellular DNA damage by protecting against oxidative stress.

Free radical scavenging capacity and protective effect ofBacopa monniera L. on DNA damage

2003 ◽  
Vol 17 (8) ◽  
pp. 870-875 ◽  
Author(s):  
Alessandra Russo ◽  
Angelo A. Izzo ◽  
Francesca Borrelli ◽  
Marcella Renis ◽  
Angelo Vanella
Keyword(s):  
Dna Damage ◽  
Free Radical ◽  
Protective Effect ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Radical Scavenging Capacity ◽  
Scavenging Capacity

Vanadium(IV)-mediated free radical generation and related 2′-deoxyguanosine hydroxylation and DNA damage

Toxicology ◽  
1996 ◽  
Vol 106 (1-3) ◽  
pp. 27-38 ◽  
Author(s):  
Xianglin Shi ◽  
Hengguang Jiang ◽  
Yan Mao ◽  
Jianping Ye ◽  
Umberto Saffiotti
Keyword(s):  
Dna Damage ◽  
Free Radical ◽  
Free Radical Generation ◽  
Radical Generation

Analysis of Free-Radical Scavenging of Yerba Mate (Ilex paraguriensis) using Electron Spin Resonance and Radical-Induced DNA Damage

2010 ◽  
Vol 75 (1) ◽  
pp. C14-C20 ◽  
Author(s):  
Stephen S. Leonard ◽  
Vallie J. Hogans ◽  
Zulema Coppes-Petricorena ◽  
Cody J. Peer ◽  
Timothy A. Vining ◽  
...  
Keyword(s):  
Dna Damage ◽  
Electron Spin Resonance ◽  
Free Radical ◽  
Electron Spin ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Yerba Mate ◽  
Spin Resonance
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