Functionalized Multi Walled Carbon Nanotubes as a Carrier for Doxorubicin: Drug Adsorption Study and Statistical Optimization of Drug Loading by Factorial Design Methodology

A dry-powder inhaler (DPI) carries medication to lungs as a dry powder, useful against respiratory diseases. The current research was endeavoured to examine the capabilities of Multi-walled carbon nanotubes (MWCNT) as a pulmonary transporter for directing cefdinir to cystic fibrosis (CF). Functionalized MWCNTs were loaded with cefdinir to formulate DPI (F-CEF FMWCNTs DPI) having efficient treatment against lung infections and were evaluated successfully. The outcomes demonstrated that cefdinir loaded FMWCNTs were non-toxic and accomplished 79.73 % entrapment with better flow properties. The optimized formulation had Mass Median Aerodynamic Diameter (MMAD), Fine particle fraction (FPF), and particle size of 3.45±0.09 μm, 58.52±1.06%, 5.25 ± 0.03 μm (CEF FMWCNT DPI) and 4. 29±0.16μm 38.74±1.02%, 7.54 ± 0.02 μm (C-DPI) respectively. The loaded nanotubes showed 72. 63 % release after 15 hours in a controlled manner. The outcome of work recognized a unique, simple, and stable product having improved drug loading and increased dispersibility of carbon nanotubes (CNTs) thus improved bioavailability at a lung infection place with less adverse actions.

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Optimization of thiamethoxam adsorption parameters using multi-walled carbon nanotubes by means of fractional factorial design

Chemosphere ◽

10.1016/j.chemosphere.2015.06.042 ◽

2015 ◽

Vol 141 ◽

pp. 87-93 ◽

Cited By ~ 19

Author(s):

Sanja Panić ◽

Dušan Rakić ◽

Valéria Guzsvány ◽

Erne Kiss ◽

Goran Boskovic ◽

...

Keyword(s):

Carbon Nanotubes ◽

Factorial Design ◽

Fractional Factorial Design ◽

Fractional Factorial ◽

Adsorption Parameters ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

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Nanohybrid Nanoparticles Based on Chitosan/Functionalized Carbon Nanotubes as Anti-HIV Nanocarrier

NANO ◽

10.1142/s1793292015500101 ◽

2015 ◽

Vol 10 (01) ◽

pp. 1550010 ◽

Cited By ~ 10

Author(s):

R. Afshari ◽

S. Mazinani ◽

M. Abdouss

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Carbon Nanotube ◽

Drug Delivery Systems ◽

Drug Loading ◽

Delivery Systems ◽

Potential Applications ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-walled carbon nanotubes (MWCNT) as nanoreservoirs for drug loading and controlled release is demonstrated. We synthesized different carbon nanotube-based drug delivery systems including acid and amide-functionalized MWCNT; chitosan (CS) covalently grafted to functionalized MWCNT and MWCNT-CS nanoparticles (NPs) using an ionotropic gelation method as a sustained-release systems for delivery of Tenofovir (hydrophilic anti-retroviral drug). The prepared NPs as different drug delivery systems were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). As it is shown, in vitro drug release studies indicated that the cumulative release rate of Tenofovir from MWCNT–CS NPs shows the best result and it reaches the maximum value (90%) after about 120 h. Moreover, comparing to ungrafted CNTs, MWCNT–CS shows high dispersability and long-term stability in aqueous medium which approves the effective solubilization of MWCNT followed by grafting with CS.

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Multi-walled carbon nanotubes as sorptive material for solventless in-tube microextraction (ITEX2)—a factorial design study

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-013-7249-7 ◽

2013 ◽

Vol 405 (26) ◽

pp. 8387-8395 ◽

Cited By ~ 21

Author(s):

Thorsten Hüffer ◽

Xochitli L. Osorio ◽

Maik A. Jochmann ◽

Beat Schilling ◽

Torsten C. Schmidt

Keyword(s):

Carbon Nanotubes ◽

Factorial Design ◽

Design Study ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

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Synthesis and adsorption study of hyper-crosslinked styrene-based nanocomposites containing multi-walled carbon nanotubes

RSC Advances ◽

10.1039/c6ra25481k ◽

2017 ◽

Vol 7 (12) ◽

pp. 6865-6874 ◽

Cited By ~ 20

Author(s):

R. Castaldo ◽

R. Avolio ◽

M. Cocca ◽

G. Gentile ◽

M. E. Errico ◽

...

Keyword(s):

Carbon Nanotubes ◽

Microporous Materials ◽

Adsorption Study ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

New nanocomposite microporous materials obtained by adding functionalized multi-walled carbon nanotubes to styrene/vinylbenzyl chloride/divinylbenzene hyper-crosslinked resins were prepared and characterized.

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Evaluation of single-Walled and Multi-Walled Carbon Nanotubes Efficiency for Removal of Acetaminophen removal from Aquatic Solutions: isotherm and kintick adsorption study

Journal of Birjand University of Medical Sciences ◽

10.32592/jbirjandunivmedsci.2019.26.3.102 ◽

2019 ◽

Vol 7 (3) ◽

pp. 198-212

Keyword(s):

Carbon Nanotubes ◽

Adsorption Study ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

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Preparation and Properties of Thrombus-Targeted Urokinase/Multi-Walled Carbon Nanotubes (MWCNTs)-Chitosan (CS)-RGD Drug Delivery System

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3113 ◽

2021 ◽

Vol 17 (9) ◽

pp. 1711-1725

Author(s):

Ru Zhang ◽

Shang Luo ◽

Lin-Kun Hao ◽

Yun-Ying Jiang ◽

Ying Gao ◽

...

Keyword(s):

Carbon Nanotubes ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Loading ◽

Rabbit Model ◽

Order Kinetic ◽

Thrombolytic Drug ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

In order to improve the therapeutic effect, prolong the action time and reduce the side effects of the first generation thrombolytic drug urokinase (UK), a novel UK/multi-walled carbon nanotubes (MWCNTs)-chitosan (CS)-arginine-glycine-aspartic acid (Arg-Gly-Asp) (RGD) drug delivery system was synthesized by chemical bonding/non covalent bond modification/ultrasonic dispersion. The results showed that the diameter of the UK/MWCNTs-CS-RGD drug delivery system was about 30–40 nm, there was a layer of UK was attached to the surface of the tube wall, and the distribution was relatively uniform. The average encapsulation efficiency was 83.10%, and the average drug loading was 12.81%. Interestingly, it also had a certain sustained-release effect, and its release law was best fitted by first-order kinetic equation. Moreover, the accelerated and long-term stability test results show that it had good stability. Compared with free UK, UK/MWCNTs-CS-RGD had thrombolytic effect in vitro. In addition, MTT experiment showed that the prepared MWCNTs-CS-RGD nanomaterials had good biocompatibility. A rabbit model of carotid artery thrombosis was used to conduct targeted thrombolysis experiments in vivo. Compared with free UK, UK/MWCNTs-CS-RGD could be enriched in the thrombosis site to achieve thrombus targeting. UK/MWCNTs-CS-RGD drug delivery system was expected to become an effective thrombolytic drug for targeted therapy of thrombosis.

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