Preparation and Properties of Thrombus-Targeted Urokinase/Multi-Walled Carbon Nanotubes (MWCNTs)-Chitosan (CS)-RGD Drug Delivery System

2021 ◽  
Vol 17 (9) ◽  
pp. 1711-1725
Author(s):  
Ru Zhang ◽  
Shang Luo ◽  
Lin-Kun Hao ◽  
Yun-Ying Jiang ◽  
Ying Gao ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Rabbit Model ◽  
Order Kinetic ◽  
Thrombolytic Drug ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

In order to improve the therapeutic effect, prolong the action time and reduce the side effects of the first generation thrombolytic drug urokinase (UK), a novel UK/multi-walled carbon nanotubes (MWCNTs)-chitosan (CS)-arginine-glycine-aspartic acid (Arg-Gly-Asp) (RGD) drug delivery system was synthesized by chemical bonding/non covalent bond modification/ultrasonic dispersion. The results showed that the diameter of the UK/MWCNTs-CS-RGD drug delivery system was about 30–40 nm, there was a layer of UK was attached to the surface of the tube wall, and the distribution was relatively uniform. The average encapsulation efficiency was 83.10%, and the average drug loading was 12.81%. Interestingly, it also had a certain sustained-release effect, and its release law was best fitted by first-order kinetic equation. Moreover, the accelerated and long-term stability test results show that it had good stability. Compared with free UK, UK/MWCNTs-CS-RGD had thrombolytic effect in vitro. In addition, MTT experiment showed that the prepared MWCNTs-CS-RGD nanomaterials had good biocompatibility. A rabbit model of carotid artery thrombosis was used to conduct targeted thrombolysis experiments in vivo. Compared with free UK, UK/MWCNTs-CS-RGD could be enriched in the thrombosis site to achieve thrombus targeting. UK/MWCNTs-CS-RGD drug delivery system was expected to become an effective thrombolytic drug for targeted therapy of thrombosis.

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

2016 ◽  
Vol 4 (21) ◽  
pp. 3823-3831 ◽  
Author(s):  
Stefano Fedeli ◽  
Alberto Brandi ◽  
Lorenzo Venturini ◽  
Paola Chiarugi ◽  
Elisa Giannoni ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Multi Walled Carbon Nanotube ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Straightforward Approach

An efficient drug delivery system through a straightforward approach to multi-walled carbon nanotube decoration.

Single-walled and multi-walled carbon nanotubes based drug delivery system: Cancer therapy: A review

2015 ◽  
Vol 52 (3) ◽  
pp. 262 ◽  
Author(s):  
B Dineshkumar ◽  
K Krishnakumar ◽  
AR Bhatt ◽  
D Paul ◽  
J Cherian ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

The Use of Multi-Walled Carbon Nanotubes as Possible Carrier in Drug Delivery System for Aspirin

2009 ◽  
Author(s):  
Alias Mohd. Yusof ◽  
Nor Aziah Buang ◽  
Lee Sze Yean ◽  
Mohd. Lokman Ibrahim ◽  
Mohamad Rusop ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Invitro study of multiwall carbon nanotubes (MWCNTs) with adsorbed mitoxantrone (MTO) as a drug delivery system to treat breast cancer

RSC Advances ◽  
2014 ◽  
Vol 4 (36) ◽  
pp. 18683-18693 ◽  
Author(s):  
Giulia Risi ◽  
Nora Bloise ◽  
Daniele Merli ◽  
Antonia Icaro-Cornaglia ◽  
Antonella Profumo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multiwall Carbon Nanotubes ◽  
System P ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Treat Breast Cancer

Mitoxantrone 600 dpi in TIF format)??>(MTO) is a well-known anticancer drug. In order to improve its therapeutic effect, multi-walled carbon nanotubes (MWCNTs) were studied in vitro as a drug delivery system.

Nanohybrid Nanoparticles Based on Chitosan/Functionalized Carbon Nanotubes as Anti-HIV Nanocarrier

NANO ◽  
2015 ◽  
Vol 10 (01) ◽  
pp. 1550010 ◽  
Author(s):  
R. Afshari ◽  
S. Mazinani ◽  
M. Abdouss
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-walled carbon nanotubes (MWCNT) as nanoreservoirs for drug loading and controlled release is demonstrated. We synthesized different carbon nanotube-based drug delivery systems including acid and amide-functionalized MWCNT; chitosan (CS) covalently grafted to functionalized MWCNT and MWCNT-CS nanoparticles (NPs) using an ionotropic gelation method as a sustained-release systems for delivery of Tenofovir (hydrophilic anti-retroviral drug). The prepared NPs as different drug delivery systems were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). As it is shown, in vitro drug release studies indicated that the cumulative release rate of Tenofovir from MWCNT–CS NPs shows the best result and it reaches the maximum value (90%) after about 120 h. Moreover, comparing to ungrafted CNTs, MWCNT–CS shows high dispersability and long-term stability in aqueous medium which approves the effective solubilization of MWCNT followed by grafting with CS.

Sign in / Sign up

Export Citation Format

Share Document