Nanohybrid Nanoparticles Based on Chitosan/Functionalized Carbon Nanotubes as Anti-HIV Nanocarrier

NANO ◽  
2015 ◽  
Vol 10 (01) ◽  
pp. 1550010 ◽  
Author(s):  
R. Afshari ◽  
S. Mazinani ◽  
M. Abdouss
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-walled carbon nanotubes (MWCNT) as nanoreservoirs for drug loading and controlled release is demonstrated. We synthesized different carbon nanotube-based drug delivery systems including acid and amide-functionalized MWCNT; chitosan (CS) covalently grafted to functionalized MWCNT and MWCNT-CS nanoparticles (NPs) using an ionotropic gelation method as a sustained-release systems for delivery of Tenofovir (hydrophilic anti-retroviral drug). The prepared NPs as different drug delivery systems were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). As it is shown, in vitro drug release studies indicated that the cumulative release rate of Tenofovir from MWCNT–CS NPs shows the best result and it reaches the maximum value (90%) after about 120 h. Moreover, comparing to ungrafted CNTs, MWCNT–CS shows high dispersability and long-term stability in aqueous medium which approves the effective solubilization of MWCNT followed by grafting with CS.

Calcium phosphate porous pellets as drug delivery systems: Effect of drug carrier composition on drug loading and in vitro release

2012 ◽  
Vol 32 (11) ◽  
pp. 2679-2690 ◽  
Author(s):  
Hiva Baradari ◽  
Chantal Damia ◽  
Maggy Dutreih-Colas ◽  
Etienne Laborde ◽  
Nathalie Pécout ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Vitro Release

scholarly journals The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 230 ◽  
Author(s):  
Jie Xu ◽  
Xueyan Hu ◽  
Siyu Jiang ◽  
Yiwei Wang ◽  
Roxanne Parungao ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Bone Tissue ◽  
Optimal Growth ◽  
Bone Tissue Regeneration ◽  
Proliferation And Differentiation ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Hybrid Scaffolds

In this study, composite scaffolds with different multi-walled carbon nanotubes (MWCNTs) content were prepared by freeze-drying. These scaffolds were characterized by scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), porosity, hydrophilicity, mechanical strength, and degradation. The MWCNTs scaffolds were structurally sound and had porous structures that offered ample space for adherence, proliferation, and differentiation of MC3T3-E1 cells, and also supported the transport of nutrients and metabolic waste. CS/Gel/nHAp/0.3%MWCNTs scaffolds provided the best outcomes in terms of scaffold porosity, hydrophilicity, and degradation rate. However, CS/Gel/nHAp/0.6%MWCNTs scaffolds were found to support the optimal growth, homogenous distribution, and biological activity of MC3T3-E1 cells. The excellent properties of CS/Gel/nHAp/0.6%MWCNTs scaffolds for the adhesion, proliferation, and osteogenesis differentiation of MC3T3-E1 cells in vitro highlights the potential applications of this scaffold in bone tissue regeneration.

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

2016 ◽  
Vol 4 (21) ◽  
pp. 3823-3831 ◽  
Author(s):  
Stefano Fedeli ◽  
Alberto Brandi ◽  
Lorenzo Venturini ◽  
Paola Chiarugi ◽  
Elisa Giannoni ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Multi Walled Carbon Nanotube ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Straightforward Approach

An efficient drug delivery system through a straightforward approach to multi-walled carbon nanotube decoration.

Stimuli-responsive Polymeric nanosystems for therapeutic applications

2021 ◽  
Vol 27 ◽  
Author(s):  
Mayank Handa ◽  
Ajit Singh ◽  
S.J.S. Flora ◽  
Rahul Shukla
Keyword(s):  
Drug Delivery ◽  
Metallic Nanoparticles ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Delivery Systems ◽  
Specific Drug ◽  
Stimuli Responsive

Background: Recent past decades have reported emerging of polymeric nanoparticles as a promising technique for controlled and targeted drug delivery. As nanocarriers, they have high drug loading and delivery to the specific site or targeted cells with an advantage of no drug leakage within en route and unloading of a drug in a sustained fashion at the site. These stimuli-responsive systems are functionalized in dendrimers, metallic nanoparticles, polymeric nanoparticles, liposomal nanoparticles, quantum dots. Purpose of Review: The authors reviewed the potential of smart stimuli-responsive carriers for therapeutic application and their behavior in external or internal stimuli like pH, temperature, redox, light, and magnet. These stimuli-responsive drug delivery systems behave differently in In vitro and In vivo drug release patterns. Stimuli-responsive nanosystems include both hydrophilic and hydrophobic systems. This review highlights the recent development of the physical properties and their application in specific drug delivery. Conclusion: The stimuli (smart, intelligent, programmed) drug delivery systems provide site-specific drug delivery with potential therapy for cancer, neurodegenerative, lifestyle disorders. As development and innovation, the stimuli-responsive based nanocarriers are moving at a fast pace and huge demand for biocompatible and biodegradable responsive polymers for effective and safe delivery.

Preparation and Properties of Thrombus-Targeted Urokinase/Multi-Walled Carbon Nanotubes (MWCNTs)-Chitosan (CS)-RGD Drug Delivery System

2021 ◽  
Vol 17 (9) ◽  
pp. 1711-1725
Author(s):  
Ru Zhang ◽  
Shang Luo ◽  
Lin-Kun Hao ◽  
Yun-Ying Jiang ◽  
Ying Gao ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Rabbit Model ◽  
Order Kinetic ◽  
Thrombolytic Drug ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

In order to improve the therapeutic effect, prolong the action time and reduce the side effects of the first generation thrombolytic drug urokinase (UK), a novel UK/multi-walled carbon nanotubes (MWCNTs)-chitosan (CS)-arginine-glycine-aspartic acid (Arg-Gly-Asp) (RGD) drug delivery system was synthesized by chemical bonding/non covalent bond modification/ultrasonic dispersion. The results showed that the diameter of the UK/MWCNTs-CS-RGD drug delivery system was about 30–40 nm, there was a layer of UK was attached to the surface of the tube wall, and the distribution was relatively uniform. The average encapsulation efficiency was 83.10%, and the average drug loading was 12.81%. Interestingly, it also had a certain sustained-release effect, and its release law was best fitted by first-order kinetic equation. Moreover, the accelerated and long-term stability test results show that it had good stability. Compared with free UK, UK/MWCNTs-CS-RGD had thrombolytic effect in vitro. In addition, MTT experiment showed that the prepared MWCNTs-CS-RGD nanomaterials had good biocompatibility. A rabbit model of carotid artery thrombosis was used to conduct targeted thrombolysis experiments in vivo. Compared with free UK, UK/MWCNTs-CS-RGD could be enriched in the thrombosis site to achieve thrombus targeting. UK/MWCNTs-CS-RGD drug delivery system was expected to become an effective thrombolytic drug for targeted therapy of thrombosis.

Study on the Surface Modification and Dispersion of Multi-Walled Carbon Nanotubes

2009 ◽  
Vol 79-82 ◽  
pp. 609-612
Author(s):  
Guan Hui Gao ◽  
Shou Gang Chen ◽  
Rui Ting Xue ◽  
Yan Sheng Yin
Keyword(s):  
Carbon Nanotubes ◽  
Surface Modification ◽  
Carbon Nanotube ◽  
Organic Solvents ◽  
Multi Walled Carbon Nanotube ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

The potential applications of carbon nanotubes are reviewed in this paper. With the development of modification and purification of carbon nanotubes, the scope of carbon nanotubes applications is expanded greatly. This paper pays attention to the modification and dispersion of multi-walled carbon nanotube (MWNTs). The results show that the acid treated MWNTs are highly pure and the surface of treated MWNTs is rough comparably. In addition, treated MWNTs are homogeneously dispersed without any surfactants present in organic solvents of acetone, toluene, and ethanol; the dispersive stability of carboxylic MWNTs dispersions is investigated over 2 weeks.

Synthesis and in vitro Evaluation of Tamoxifen-Loaded Gelatin as Effective Nanocomplex in Drug Delivery Systems

2020 ◽  
Vol 19 (05) ◽  
pp. 2050002
Author(s):  
Nasrin Faramarzi ◽  
Javad Mohammadnejad ◽  
Hanieh Jafary ◽  
Asghar Narmani ◽  
Mojtaba Koosha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Death ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Gelatin Nanoparticles ◽  
Drug Efficiency ◽  
Mcf 7

Recently, using gelatin nanoparticles as a biocompatible carrier in drug delivery systems is growing up. Drug delivery is one of the most common applications of nanoparticles in cancer treatment in order to optimize the drug efficiency. In this study, gelatin nanoparticles were firstly synthesized and loaded with tamoxifen that subsequently characterized by SEM, TGA and FT-IR analyses. The approximate drug loading efficiency was calculated about 17.43% for tamoxifen-loaded gelatin (TG). Then, the effect of TG on apoptosis induction and cytotoxicity of MCF-7 cell line was evaluated and compared with flow cytometry and MTT assay. The MTT results showed that tamoxifen and TG nanoparticles could inhibit the proliferation of MCF-7 cells in a dose-responsive manner, with an IC[Formula: see text] of IC[Formula: see text] of 200 [Formula: see text]g/mL and 50 [Formula: see text]g/mL after 24[Formula: see text]h and 48[Formula: see text]h, respectively. Moreover, from flow cytometric results, it can be suggested that TG nanoparticles are more potent in inducing apoptosis and cell death through programmed cell death. Actually, TG nanoparticles primarily increased the early apoptotic cells during the 24-h incubation period Our results revealed that tamoxifen-loaded gelatin nanoparticles are more potent than tamoxifen alone. These findings support the use of tamoxifen-loaded gelatin nanoparticles in target-specific therapy for cancer treatment.

Use of Pseudoboehmite Nanoparticles for Drug Delivery System of Glucantime®

2016 ◽  
Vol 38 ◽  
pp. 47-51 ◽  
Author(s):  
A.H. Munhoz ◽  
J.S. Martins ◽  
R.R. Ribeiro ◽  
L.F. Miranda ◽  
R.C. Andrades ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Sol Gel ◽  
Delivery Systems ◽  
Active Principle ◽  
Aluminum Compound ◽  
Vis Spectroscopy ◽  
Sol Gel Process ◽  
Potential Applications

Recently, the incidence of American Cutaneous Leishmaniasis (ACL) has been grown in Latin America, especially in Brazil, where from 1980 to 2005, 605,062 cases were recorded. The drug glucantime®, whose active principle is the meglumine antimoniate (or meglumine antimonate) is used in the treatment of leishmaniasis. Its toxicity is due mainly to the presence of antimony in its structure. Therefore, it is crucial to determine the safe dose levels of this drug in the treatment. Drug delivery systems have been currently the focus of many studies due to its effectiveness in treating diseases proved to be superior compared to conventional methods. Drug delivery systems can avoid overdosing by decreasing the amount of drug intake, which results in a better therapeutic effect in addition to reducing the risks of plasma concentration reaching toxic levels. Synthetic nanomaterials have been receiving great attention due to their potential applications in pharmaceutical technology as well as the possibility of controlling their particle size and composition, which allows a better performance in drug release. Pseudoboehmite is a synthetic aluminum compound precursor of alumina [1] and a polymorph of boehmite, with active groups in its structure [2], making it an excellent adsorbent material. In this work, pseudoboehmite was prepared by using the sol-gel process for being used as an excipient. The incorporation of pseudoboehmite in glucantime® was performed in the processing of tablets. Both pseudoboehmite and the tablets were characterized via X-ray diffraction (XRD), differential thermal analysis (DTA), thermogravimetric analysis (TG), and scanning electron microscopy (SEM) using secondary electron detector and EDS detector. The release profile was obtained by UV/Vis spectroscopy for in vitro simulation. No reaction between the drug and the excipient was observed.

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