Development of cefdinir loaded Functionalized carbon Nanotubes dry powder Inhaler for the Treatment of cystic Fibrosis

2021 ◽  
pp. 3839-3845
Author(s):  
Krishnat D. Dhekale ◽  
Ravindra N. Kamble
Keyword(s):  
Carbon Nanotubes ◽  
Cystic Fibrosis ◽  
Drug Loading ◽  
Dry Powder Inhaler ◽  
Dry Powder ◽  
Efficient Treatment ◽  
Multi Walled Carbon Nanotubes ◽  
Stable Product ◽  
Lung Infections ◽  
Walled Carbon Nanotubes

A dry-powder inhaler (DPI) carries medication to lungs as a dry powder, useful against respiratory diseases. The current research was endeavoured to examine the capabilities of Multi-walled carbon nanotubes (MWCNT) as a pulmonary transporter for directing cefdinir to cystic fibrosis (CF). Functionalized MWCNTs were loaded with cefdinir to formulate DPI (F-CEF FMWCNTs DPI) having efficient treatment against lung infections and were evaluated successfully. The outcomes demonstrated that cefdinir loaded FMWCNTs were non-toxic and accomplished 79.73 % entrapment with better flow properties. The optimized formulation had Mass Median Aerodynamic Diameter (MMAD), Fine particle fraction (FPF), and particle size of 3.45±0.09 μm, 58.52±1.06%, 5.25 ± 0.03 μm (CEF FMWCNT DPI) and 4. 29±0.16μm 38.74±1.02%, 7.54 ± 0.02 μm (C-DPI) respectively. The loaded nanotubes showed 72. 63 % release after 15 hours in a controlled manner. The outcome of work recognized a unique, simple, and stable product having improved drug loading and increased dispersibility of carbon nanotubes (CNTs) thus improved bioavailability at a lung infection place with less adverse actions.

Nanohybrid Nanoparticles Based on Chitosan/Functionalized Carbon Nanotubes as Anti-HIV Nanocarrier

NANO ◽  
2015 ◽  
Vol 10 (01) ◽  
pp. 1550010 ◽  
Author(s):  
R. Afshari ◽  
S. Mazinani ◽  
M. Abdouss
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-walled carbon nanotubes (MWCNT) as nanoreservoirs for drug loading and controlled release is demonstrated. We synthesized different carbon nanotube-based drug delivery systems including acid and amide-functionalized MWCNT; chitosan (CS) covalently grafted to functionalized MWCNT and MWCNT-CS nanoparticles (NPs) using an ionotropic gelation method as a sustained-release systems for delivery of Tenofovir (hydrophilic anti-retroviral drug). The prepared NPs as different drug delivery systems were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). As it is shown, in vitro drug release studies indicated that the cumulative release rate of Tenofovir from MWCNT–CS NPs shows the best result and it reaches the maximum value (90%) after about 120 h. Moreover, comparing to ungrafted CNTs, MWCNT–CS shows high dispersability and long-term stability in aqueous medium which approves the effective solubilization of MWCNT followed by grafting with CS.

Preparation and Properties of Thrombus-Targeted Urokinase/Multi-Walled Carbon Nanotubes (MWCNTs)-Chitosan (CS)-RGD Drug Delivery System

2021 ◽  
Vol 17 (9) ◽  
pp. 1711-1725
Author(s):  
Ru Zhang ◽  
Shang Luo ◽  
Lin-Kun Hao ◽  
Yun-Ying Jiang ◽  
Ying Gao ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Rabbit Model ◽  
Order Kinetic ◽  
Thrombolytic Drug ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

In order to improve the therapeutic effect, prolong the action time and reduce the side effects of the first generation thrombolytic drug urokinase (UK), a novel UK/multi-walled carbon nanotubes (MWCNTs)-chitosan (CS)-arginine-glycine-aspartic acid (Arg-Gly-Asp) (RGD) drug delivery system was synthesized by chemical bonding/non covalent bond modification/ultrasonic dispersion. The results showed that the diameter of the UK/MWCNTs-CS-RGD drug delivery system was about 30–40 nm, there was a layer of UK was attached to the surface of the tube wall, and the distribution was relatively uniform. The average encapsulation efficiency was 83.10%, and the average drug loading was 12.81%. Interestingly, it also had a certain sustained-release effect, and its release law was best fitted by first-order kinetic equation. Moreover, the accelerated and long-term stability test results show that it had good stability. Compared with free UK, UK/MWCNTs-CS-RGD had thrombolytic effect in vitro. In addition, MTT experiment showed that the prepared MWCNTs-CS-RGD nanomaterials had good biocompatibility. A rabbit model of carotid artery thrombosis was used to conduct targeted thrombolysis experiments in vivo. Compared with free UK, UK/MWCNTs-CS-RGD could be enriched in the thrombosis site to achieve thrombus targeting. UK/MWCNTs-CS-RGD drug delivery system was expected to become an effective thrombolytic drug for targeted therapy of thrombosis.

Dry powder inhaler of colistimethate sodium for lung infections in cystic fibrosis: optimization of powder construction

2019 ◽  
Vol 45 (10) ◽  
pp. 1664-1673 ◽  
Author(s):  
Jana Kozáková ◽  
Ayça Altay ◽  
Vladimír Ždímal ◽  
Ludmila Mašková ◽  
Fabio Sonvico ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Dry Powder Inhaler ◽  
Dry Powder ◽  
Colistimethate Sodium ◽  
Lung Infections

Multi-walled Carbon Nanotubes Penetrate into Plant Cells and Affect the Growth of Onobrychis arenaria Seedlings

Acta Naturae ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 99-106 ◽  
Author(s):  
E A Smirnova ◽  
A A Gusev ◽  
O N Zaitseva ◽  
E M Lazareva ◽  
G E Onishchenko ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Plant Cells ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Incorporation of Multi Wall Carbon Nanotubes into Glass-Surfaces via Laser-Treatment

2003 ◽  
Vol 772 ◽  
Author(s):  
T. Seeger ◽  
G. de la Fuente ◽  
W.K. Maser ◽  
A.M. Benito ◽  
A. Righi ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Continuous Wave ◽  
Silica Surface ◽  
Multi Wall Carbon Nanotubes ◽  
Composite Formation ◽  
Multi Walled Carbon Nanotubes ◽  
Glass Surfaces ◽  
Walled Carbon Nanotubes ◽  
First Time ◽  
Scanning Electron

AbstractCarbon nanotubes (CNT) are interesting candidates for the reinforcement in robust composites and for conducting fillers in polymers due to their fascinating electronic and mechanical properties. For the first time, we report the incorporation of multi walled carbon nanotubes (MWNTs) into silica-glass surfaces by means of partial surface-melting caused by a continuous wave Nd:YAG laser. MWNTs were detected being well incorporated in the silica-surface. The composites are characterized using scanning electron microscopy (SEM) and Raman-spectroscopy. A model for the composite-formation is proposed based on heatabsorption by MWNTs and a partial melting of the silica-surface.

Sign in / Sign up

Export Citation Format

Share Document