scholarly journals Right Ventricular Doppler Echocardiographic Study of Indeterminate Form of Chagas Disease

2014 ◽  
Author(s):  
Rogério Gomes Furtado ◽  
Daniela do Carmo Rassi Frota ◽  
João Batista Masson Silva ◽  
Minna Moreira Dias Romano ◽  
Oswaldo César de Almeida Filho ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Chagas Disease ◽  
Echocardiographic Study ◽  
Indeterminate Form

scholarly journals Echocardiographic Study of the Coronary Sinus in the Indeterminate Form of Chagas Disease

2018 ◽  
Vol 51 (6) ◽  
pp. 827-830
Author(s):  
Glauco Andre Machado ◽  
Dalton Alexandre dos Anjos ◽  
Flávia de Freitas Rodrigues ◽  
Renata Fockink dos Anjos ◽  
Marcelo Barbosa Melo Luckemeyer ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Coronary Sinus ◽  
Echocardiographic Study ◽  
Indeterminate Form

Magnetic resonance imaging in experimental Chagas disease: a brief review of the utility of the method for monitoring right ventricular chamber dilatation

2005 ◽  
Vol 97 (2) ◽  
pp. 87-90 ◽  
Author(s):  
Andréa P. de Souza ◽  
Baiyu Tang ◽  
Herbert B. Tanowitz ◽  
Tania C. Araújo-Jorge ◽  
e Linda A. Jelicks
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Right Ventricular ◽  
Chagas Disease ◽  
Resonance Imaging

MO742PRELOAD DEPENDENCE OF PULMONARY HAEMODYNAMICS AND RIGHT VENTRICULAR PERFORMANCE: AN ECHOCARDIOGRAPHIC STUDY IN PATIENTS ON HAEMODIALYSIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Francesc Gual-Capllonch ◽  
Fredzzia Graterol ◽  
Jordi Soler Majoral ◽  
Ioana Bancu ◽  
Elena Ferrer-Sistach ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Longitudinal Strain ◽  
Systolic Pulmonary Artery Pressure ◽  
Ventricular Performance ◽  
Fluid Removal ◽  
Functional Tricuspid Regurgitation ◽  
Echocardiographic Study ◽  
Pulmonary Haemodynamics ◽  
Before And After ◽  
Right Ventricular Performance

Abstract Background and Aims Haemodynamic cardiac changes in haemodialysis are associated with adverse cardiovascular outcomes and and they are difficult to measure. Systolic pulmonary artery pressure (SPAP) and right heart adaptation in relation to pre-existing preload are often disregarded. To determine volume-related changes in the pulmonary-right ventricle (RV) unit and the preload-dependence of its components, we analysed pulmonary haemodynamics and right ventricular performance, taking advantage of the plasma volume removal associated to haemodialysis (HD). Methods and results Fifty-three stable patients on chronic HD with LVEF >50% and without heart failure were recruited (mean age 63.0±12.4 years; 31.2% women; hypertension in 89% and diabetes in 53%) and evaluated just before and after HD (mean ultrafiltration volume 2.4±0.7l). SPAP from both times were available in 39 patients. After HD, SPAP decreased (42.2±12.6 to 33.7±11.6 mmHg, p<0.001) without modification of non-invasive pulmonary vascular resistance (1.75±0.44 to 1.75±0.40 eWU, p=0.94). Age and drop in the E/e’ ratio were the variables associated with greater reduction in PASP (p=0.022 and p=0.049, respectively). A significant reduction of right chamber sizes was observed, along with a diminution in measures of RV contractility, excluding RV longitudinal strain. Functional tricuspid regurgitation (FTR) diminution was observed in 26% of patients, occurring in every case with more than mild FTR. On multivariate analyses, left atrial size was the only predictor of pulmonary hypertension (defined as SPAP >40 mmHg) (OR 1.29 (1.07–1.56), p=0.006). Conclusion Rapid volemic changes determined by rapid fluid removal during hemodialysis; may affect FTR grading, RV size and contractility, with RV longitudinal strain being less variable than conventional parameters. SPAP decreases after HD, and this reduction is related to age and greater diminution of the E/e′ ratio.

scholarly journals Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy

2019 ◽  
Vol 20 (16) ◽  
pp. 4064 ◽  
Author(s):  
Carolina Kymie Vasques Nonaka ◽  
Carolina Thé Macêdo ◽  
Bruno Raphael Ribeiro Cavalcante ◽  
Adriano Costa de Alcântara ◽  
Daniela Nascimento Silva ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Cardiac Fibrosis ◽  
Left Ventricular ◽  
Pharmacological Therapy ◽  
Functional Class ◽  
Diagnostic Methods ◽  
Individual Risk ◽  
Indeterminate Form ◽  
Potential Biomarkers

Chagas disease (CD) affects approximately 6–7 million people worldwide, from which 30% develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years. Currently available diagnostic methods are capable of adequately identifying infected patients, but do not provide information regarding the individual risk of developing the most severe form of the disease. The identification of biomarkers that predict the progression from asymptomatic or indeterminate form to CCC, may guide early implementation of pharmacological therapy. Here, six circulating microRNAs (miR-19a-3p, miR-21-5p, miR-29b-3p, miR-30a-5p, miR-199b-5p and miR-208a-3p) were evaluated and compared among patients with CCC (n = 28), CD indeterminate form (n = 10) and healthy controls (n = 10). MiR-19a-3p, miR-21-5p, and miR-29b-3p were differentially expressed in CCC patients when compared to indeterminate form, showing a positive correlation with cardiac dysfunction, functional class, and fibrosis, and a negative correlation with ejection fraction and left ventricular strain. Cardiac tissue analysis confirmed increased expression of microRNAs in CCC patients. In vitro studies using human cells indicated the involvement of these microRNAs in the processes of cardiac hypertrophy and fibrosis. Our study suggests that miRNAs are involved in the process of cardiac fibrosis and remodeling presented in CD and indicate a group of miRNAs as potential biomarkers of disease progression in CCC.

Right Ventricular Endomyocardial Biopsy in Undetermined Form of Chagas' Disease

Angiology ◽  
1984 ◽  
Vol 35 (12) ◽  
pp. 755-759 ◽  
Author(s):  
Charles Mady ◽  
Antonio Carlos Pereira-Barretto ◽  
Bárbara Maria Ianni ◽  
Edgard Augusto Lopes ◽  
Fúlvio Pileggi
Keyword(s):  
Right Ventricular ◽  
Chagas Disease ◽  
Endomyocardial Biopsy

scholarly journals T-Cell Immunophenotyping and Cytokine Production Analysis in Patients with Chagas Disease 4 Years after Benznidazole Treatment

2019 ◽  
Vol 87 (8) ◽  
Author(s):  
Mauricio Llaguno ◽  
Marcos Vinicius da Silva ◽  
Lara Rocha Batista ◽  
Djalma Alexandre Alves da Silva ◽  
Rodrigo Cunha de Sousa ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Chronic Phase ◽  
Interleukin 10 ◽  
T Helper ◽  
T Helper 1 ◽  
Cardiac Damage ◽  
Disease Treatment ◽  
Indeterminate Form ◽  
Ifn Γ

ABSTRACT The major problem with Chagas disease is evolution of the chronic indeterminate form to a progressive cardiac disease. Treatment diminishes parasitemia but not clinical progression, and the immunological features involved are unclear. Here, we studied the clinical course and the immune response in patients with chronic-phase Chagas disease at 48 months after benznidazole treatment. Progression to the cardiac form of Chagas disease or its aggravation was associated with higher in vitro antigen-specific production of interferon gamma (IFN-γ) in patients with cardiac Chagas disease than in patients with the indeterminate form. Predominance of IFN-γ production over interleukin-10 (IL-10) production in antigen-specific cultures was associated with cardiac involvement. Significantly higher numbers of antigen-specific T helper 1 cells (T-Bet+ IFN-γ+) and a significantly higher IFN-γ+/IL-10+ ratio were observed in patients with cardiac Chagas disease than in patients with the indeterminate form. Cardiac damage was associated with higher numbers of T helper cells than cytotoxic T lymphocytes producing IFN-γ. Patients with cardiac Chagas disease had predominant CD25− and CD25low T regulatory (Treg) subpopulations, whereas patients with the indeterminate form manifested a higher relative mean percentage of CD25high Treg subpopulations. These findings suggest that at 48 months after benznidazole treatment, the disease can worsen or progress to the cardiac form. The progression may be related to increased IFN-γ production (mostly from CD4+ T cells) relative to IL-10 production and increased Treg percentages. Patients with the indeterminate form of Chagas disease show a more balanced ratio of proinflammatory and anti-inflammatory cytokines.

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