scholarly journals Clinical course of coxsackievirus B (1-6) infection

2020 ◽  
Vol 17 (1) ◽  
pp. 3-7
Author(s):  
Slađana Pavić ◽  
Marija Antić ◽  
Radmila Sparić ◽  
Aleksandra Pavić
Keyword(s):  
Aseptic Meningitis ◽  
Fever Of Unknown Origin ◽  
Antinuclear Antibodies ◽  
Clinical Course ◽  
Acute Myocarditis ◽  
Clinical Manifestations ◽  
Unknown Origin ◽  
Coxsackievirus B ◽  
Virus Serotype ◽  
Febrile Condition

Objective. Coxsackievirus B (1-6) infections are the common infections of children and adults. Clinical manifestations include fever, aseptic meningitis, pleurodinia, myocarditis, gastroenterocolitis, maculous exanthem. The clinical course of the infection is influenced by the characteristics of the host, as well as the virus serotype. The pathogenesis of the diseases is explained by the immune mediated mechanism and the direct cytotoxic effect of the virus. Methods. Retrospectively analyzed virus serotype, clinical and biochemical data in patients with coxsackievirus B (1-6) infection. Patients who had an unclear febrile condition for more than six months were tested for autoantibodies. Results. We examined a total of 378 patients with coxsackievirus B (1-6) infection (302 women, 76 men), age 19 to 79 years. The dominant symptoms were weakness, elevated body temperature, fatigue and muscle aches. In 55% the clinical course was fever of unknown origin, in 13% myalgia/pleurodinia, 9% acute gastroenterocolitis and acute myocarditis/ pericarditis, 2% aseptic meningitis, 2.4% respiratory disease, 3% acute pancreatitis and 1% diabetes mellitus. Autoantibodies were detected in 69% of patients with fever of unknown origin. Antinuclear antibodies were most common, in 67%. Serotype B2 had 36% of these patients. Serotype B2 had 36% of these patients and serotype B4 had 14%. Conclusion. The most common clinical form of coxsackievirus B (1-6) infection is an fever of unknown origin caused by a B2 serotype of the virus. In most of these patients, an elevated titre of antinuclear antibodies can be detected.

Scleroderma and Related Disorders

2017 ◽  
Author(s):  
Kristine Phillips
Keyword(s):  
Differential Diagnosis ◽  
Antinuclear Antibodies ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Diagnosis And Treatment ◽  
Localized Scleroderma ◽  
Eosinophilic Fasciitis ◽  
Tomographic Images ◽  
Computed Tomographic

Scleroderma spectrum diseases are a heterogeneous group of disorders that are distinguished by abnormalities of the connective tissue in the skin and, in some cases, other organs. Each disorder may be characterized by the extent of cutaneous and internal involvement, as well as histopathologic features of skin biopsy. Scleroderma spectrum diseases include systemic scleroderma, localized scleroderma, and eosinophilic fasciitis. This chapter reviews the classification, epidemiology, etiology, pathophysiology and pathogenesis, diagnosis, differential diagnosis, treatment, outcome measures, management, and clinical course of scleroderma as well as the definition and classification, etiology/genetics, differential diagnosis, and treatment of localized scleroderma. Also discussed are the definition and classification, epidemiology, etiology/genetics/pathogenesis, diagnosis, differential diagnosis, and treatment of eosinophilic fasciitis. Tables review the classification of—and antinuclear antibodies in—scleroderma as well as the key assessments and interventions in scleroderma management. Figures illustrate the disease's presentation and clinical manifestations, including several images of scleroderma of the hands; face, palmar, and buccal telangiectasias in a patient with scleroderma; a radiograph demonstrating calcinosis of the elbow; Raynaud’s phenomenon; high-resolution computed tomographic images of diffuse cutaneous scleroderma, scleroderma and severe pulmonary hypertension, and limited cutaneous scleroderma; plus an esophagram demonstrating hypomotility. This review contains 11 highly rendered figures, 3 tables, and 72 references.

Scleroderma and Related Disorders

2017 ◽  
Author(s):  
Kristine Phillips
Keyword(s):  
Differential Diagnosis ◽  
Antinuclear Antibodies ◽  
Clinical Course ◽  
Clinical Manifestations ◽  
Diagnosis And Treatment ◽  
Localized Scleroderma ◽  
Eosinophilic Fasciitis ◽  
Tomographic Images ◽  
Computed Tomographic

Scleroderma spectrum diseases are a heterogeneous group of disorders that are distinguished by abnormalities of the connective tissue in the skin and, in some cases, other organs. Each disorder may be characterized by the extent of cutaneous and internal involvement, as well as histopathologic features of skin biopsy. Scleroderma spectrum diseases include systemic scleroderma, localized scleroderma, and eosinophilic fasciitis. This chapter reviews the classification, epidemiology, etiology, pathophysiology and pathogenesis, diagnosis, differential diagnosis, treatment, outcome measures, management, and clinical course of scleroderma as well as the definition and classification, etiology/genetics, differential diagnosis, and treatment of localized scleroderma. Also discussed are the definition and classification, epidemiology, etiology/genetics/pathogenesis, diagnosis, differential diagnosis, and treatment of eosinophilic fasciitis. Tables review the classification of—and antinuclear antibodies in—scleroderma as well as the key assessments and interventions in scleroderma management. Figures illustrate the disease's presentation and clinical manifestations, including several images of scleroderma of the hands; face, palmar, and buccal telangiectasias in a patient with scleroderma; a radiograph demonstrating calcinosis of the elbow; Raynaud’s phenomenon; high-resolution computed tomographic images of diffuse cutaneous scleroderma, scleroderma and severe pulmonary hypertension, and limited cutaneous scleroderma; plus an esophagram demonstrating hypomotility. This review contains 11 highly rendered figures, 3 tables, and 72 references.

scholarly journals A Case Report on Fever of Unknown Origin in a School Going Child– An Uncommon Answer in a Common Question

2018 ◽  
Vol 17 (2) ◽  
pp. 58-63
Author(s):  
Dhan Bahadur Shrestha ◽  
Suju Mool ◽  
Sijan Karki
Keyword(s):  
Escherichia Coli ◽  
Bone Marrow ◽  
Case Report ◽  
Patient Care ◽  
Enteric Fever ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Bone Marrow Culture ◽  
Febrile Condition ◽  
Inpatient Department

Fever is one of the commonest complaints in paediatrics outpatient as well as inpatient department. Fever of unknown origin (FUO) is a diagnosis of exclusion given to the febrile condition lasting more than three weeks with temperature 38.30C or more with unknown cause despite of one week in patient care. Here we present a case of FUO in a child which was investigated thoroughly and managed on the line of enteric fever. However, the patient remained febrile. Hence, further investigations were undertaken and finally, bone marrow culture grew a very uncommon organism- Escherichia coli. The child was treated as per the sensitivity and responded well to treatment and was discharged after improvement. Here, we would like to present this case of FUO to highlight the possibility of bone marrow invasion by an uncommon organism as a source of fever in children.

scholarly journals Multiple Intracardiac Masses as the Primary Presentation of a Systemic Inflammatory Disease: A Big Challenge (Case Report)

2021 ◽  
Author(s):  
Zahra Khalaji ◽  
Bahar Galeshi ◽  
simin almasi ◽  
Mozhgan Parsaee ◽  
Hamidreza Pouraliakbar
Keyword(s):  
Arterial Thrombosis ◽  
Fever Of Unknown Origin ◽  
Inflammatory Diseases ◽  
Clinical Manifestations ◽  
Unknown Origin ◽  
Pregnancy Morbidity ◽  
Systemic Inflammatory Disease ◽  
Intracardiac Masses ◽  
Primary Presentation ◽  
Intracardiac Thrombi

Antiphospholipid syndrome (APS) classically presents with venous or arterial thrombosis and pregnancy morbidity. Although clinical manifestations with fever of unknown origin and intracardiac masses are unusual, in a patient with prolonged fever and multiple intracardiac thrombi, systemic inflammatory diseases such as APS should be considered.

scholarly journals TNFRSF1A gene variant identified in a boy with recurrent episodes of fever

2018 ◽  
Vol 146 (9-10) ◽  
pp. 577-580
Author(s):  
Srdja Jankovic ◽  
Goran Djuricic ◽  
Aleksandra Radosavljevic ◽  
Dragana Janic
Keyword(s):  
Fever Of Unknown Origin ◽  
Periodic Fever ◽  
Tumor Necrosis Factor Receptor ◽  
Unknown Origin ◽  
Recurrent Fever ◽  
Diagnostic Challenge ◽  
Periodic Fever Syndromes ◽  
Tnfrsf1a Gene ◽  
Febrile Condition ◽  
Fever Syndromes

Introduction. Fever of unknown origin is an important diagnostic challenge. Although rare, periodic fever syndromes may often present with a chronic or recurrent febrile condition with a variable temporal pattern of occurrence. Although clinical characteristics often indicate the syndrome in question, there are many atypical forms, and the genotype?phenotype relationship is highly complex, warranting in many cases the designation of a ?syndrome spectrum? rather than a syndrome per se. The aim of this paper was to present a boy with recurrent fever of unknown origin. Case outline. We hereby present a boy with recurrent fever of unknown origin who was by clinically guided partial exome sequencing found to have a heterozygous variant 434A>G in the TNFRSF1A gene, otherwise connected with tumor necrosis factor receptor-associated periodic fever syndrome. The patient responded well to short courses of glucocorticoids and is no longer subjected to unnecessary antibiotic treatment he had frequently received in the past. Conclusion. Periodic fever syndromes should be kept in mind as a differential diagnostic possibility in children with fever of unknown origin.

Recommendations for the inclusion of Fabry disease as a rare febrile condition in existing algorithms for fever of unknown origin

2017 ◽  
Vol 12 (7) ◽  
pp. 1059-1067 ◽  
Author(s):  
Raffaele Manna ◽  
◽  
Roberto Cauda ◽  
Sandro Feriozzi ◽  
Giovanni Gambaro ◽  
...  
Keyword(s):  
Fabry Disease ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Febrile Condition

Intraventricular chordoid meningioma in a child: fever of unknown origin, clinical course, and response to treatment

2012 ◽  
Vol 10 (6) ◽  
pp. 478-481 ◽  
Author(s):  
Ajit Nambiar ◽  
Ashok Pillai ◽  
Chirag Parmar ◽  
Dilip Panikar
Keyword(s):  
Fever Of Unknown Origin ◽  
Clinical Course ◽  
Unknown Origin ◽  
Response To Treatment ◽  
Tumor Type ◽  
Management Options ◽  
Rare Presentation ◽  
Chordoid Meningioma ◽  
Fractionated Radiotherapy ◽  
Rare Location

The authors present the case of an 11-year-old boy with an intraventricular chordoid meningioma, which is a rare presentation of prolonged fever of unknown origin due to a rare tumor in a rare location. The fever resolved after excision of the lesion. Subsequent imaging revealed recurrence at 1 year. After a repeat excision and fractionated radiotherapy, the patient has remained disease free 5 years after the first surgery. Very few cases of intraventricular chordoid meningioma have been reported to date. The pathological features and clinical course are described. A review of the literature describing management options for this tumor type, recently found to have a higher recurrence rate, is described herein.

scholarly journals Familial Mediterranean Fever with Neonatal Onset: Case Report

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Kübra Arslan ◽  
Serdar Ümit Sarici ◽  
Gonca Kolukisa ◽  
Demet Altun
Keyword(s):  
Familial Mediterranean Fever ◽  
Joint Pain ◽  
Fever Of Unknown Origin ◽  
Clinical Course ◽  
Unknown Origin ◽  
Recurrent Fever ◽  
Age Group ◽  
Neonatal Onset ◽  
Mediterranean Fever ◽  
Occult Bacteremia

Familial Mediterranean fever (FMF) is an autosomal recessively inherited disorder characterized by recurrent fever and attacks of abdominal pain, chest pain, and joint pain. Attacks of recurrent fever and serositis are encountered clinically. Attacks may present either with only one symptom or many simultaneous symptoms. Although most of the patients are diagnosed clinically above the age of 2, those cases who are diagnosed before 2 years of age and with clinical course of isolated fever are believed to have a more serious course and tend to develop amyloidosis. In this article, a case who was admitted first on the 22nd day of life and later diagnosed to have FMF with recurrent attacks of isolated fever and no other focus is presented. We emphasize that FMF may present as early as in the first month of life, and it should be considered in cases presenting with fever of unknown origin and misdiagnosed to have late neonatal sepsis or occult bacteremia at this age group.

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