Molecular imaging using by diffusion-weighted imaging of brain tumor through signal intensity: Progress in molecular cancer imaging

Background Elastofibroma dorsi is a rare pseudotumoral lesion. Thus, there is no report of magnetic resonance imaging (MRI) findings that investigates multiple patients particularly with respect to diffusion-weighted imaging (DWI) findings and contrast enhancement patterns. Purpose To describe the imaging findings of elastofibroma on MRI, particularly DWI findings and contrast enhancement patterns, and to further investigate patient demographics. Material and Methods Forty-four patients with elastofibroma that underwent MRI were enrolled in this retrospective study. All images were evaluated by two radiologists to visually assess the signal intensity for each sequence. Enhanced elastofibromas were classified into four categories to assess the enhancement pattern. Differences in gender and laterality were also assessed statistically. Results An equal number of men and women were included (n = 22 each). There was no significant difference in laterality ( P = 0.783). All lesions (73 lesions) had low signal intensity on both T1-weighted (T1W) and T2-weighted (T2W) images: heterogeneous in 56, homogeneous in 17. None of the 41 lesions with DWI had true abnormal diffusion restriction. The average ADC value was 1.36 × 10–3 ± 0.29 mm2/s. All 31 lesions that had contrast-enhanced MRI were classified according to enhancement pattern: homogeneous (three lesions, 9.7%); heterogeneous (15 lesions, 48.4%); streak-like (three lesions, 9.7%); and rim-like (ten lesions, 32.2%). Conclusion There were no statistically significant differences in gender or laterality. Elastofibroma showed homogeneous to heterogeneous low signal intensity on T1W and T2W images. No lesion showed abnormal diffusion restriction, and all lesions demonstrated enhancement on MRI.

Download Full-text

Pitfalls of diffusion-weighted imaging of the female pelvis

Radiologia Brasileira ◽

10.1590/0100-3984.2016.0208 ◽

2018 ◽

Vol 51 (1) ◽

pp. 37-44 ◽

Cited By ~ 7

Author(s):

Ana Luisa Duarte ◽

João Lopes Dias ◽

Teresa Margarida Cunha

Keyword(s):

Signal Intensity ◽

Diffusion Weighted Imaging ◽

Structural Information ◽

Biological Tissues ◽

High Signal ◽

Female Pelvis ◽

Diffusion Weighted ◽

Apparent Diffusion ◽

Mri Sequences ◽

Magnetic Resonance Imaging Mri

Abstract Diffusion-weighted imaging (DWI) is widely used in protocols for magnetic resonance imaging (MRI) of the female pelvis. It provides functional and structural information about biological tissues, without the use of ionizing radiation or intravenous administration of contrast medium. High signal intensity on DWI with simultaneous low signal intensity on apparent diffusion coefficient maps is usually associated with malignancy. However, that pattern can also be seen in many benign lesions, a fact that should be recognized by radiologists. Correlating DWI findings with those of conventional (T1- and T2-weighted) MRI sequences and those of contrast-enhanced MRI sequences is mandatory in order to avoid potential pitfalls. The aim of this review article is the description of the most relevant physiological and benign pathological conditions of the female pelvis that can show restricted diffusion on DWI.

Download Full-text

A pituitary abscess showing high signal intensity on diffusion-weighted imaging

Neurosurgical Review ◽

10.1007/s10143-006-0021-0 ◽

2006 ◽

Vol 29 (3) ◽

pp. 246-248 ◽

Cited By ~ 26

Author(s):

Takeshi Takayasu ◽

Fumiyuki Yamasaki ◽

Atsushi Tominaga ◽

Toshikazu Hidaka ◽

Kazunori Arita ◽

...

Keyword(s):

Signal Intensity ◽

Diffusion Weighted Imaging ◽

High Signal Intensity ◽

High Signal ◽

Pituitary Abscess ◽

Diffusion Weighted

Download Full-text

Susceptibility Weighted Imaging in Acute Stroke with Co-morbids: Magnetic Resonance Imaging Protocol Revisited

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2019/v29i1030134 ◽

2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Fatima Mubarak ◽

Muhammad Danish Barakzai

Keyword(s):

Signal Intensity ◽

Diffusion Weighted Imaging ◽

Surrogate Marker ◽

Rank Correlation ◽

Acute Stage ◽

High Signal ◽

Susceptibility Weighted Imaging ◽

Imaging Protocol ◽

Diffusion Weighted ◽

Acute Infarct

Introduction: We aim to investigate ischemic penumbra using Diffusion weighted imaging- Susceptibility weighted imaging mismatch using DWI Alberta Stroke Program Early Computed tomography Stroke Score scoring in patients with multiple co morbid. Methods: From January 2011 to December, 2017; 70 consecutive patients (50 men, 20 women; mean age 64.5; range 45-82 years) with acute infarct on Diffusion weighted imaging (DWI) were selected for the study. Stroke protocol performed including DWI and susceptibility weighted imaging (SWI) on first day and repeat within three days. All initial MR images were interpreted by one Neuroradiologist with more than ten years blind to the clinical findings of each patient. The definition of an acute infarct area was high signal intensity on DWI with dark signal intensity on Apparent diffusion weighted imaging (ADC). The infarct extent was scored using the Alberta Stroke Program Early CT Score (ASPECTS) system. Infarct growth was defined as any new or larger lesion on the second DWI. For correlation with infarct growth, the same topographic system was used to record the extent of the Prominent vessel sign (PVS) on SWI. Spearman’s rank correlation test was used to examine the correlations between PVS score and infarct growth score. Regression was computed, with P<0.05 considered significant. Results: The study included 12 women and 10 men, (mean age 67.1 years). MRI images were initially acquired as stroke protocol (mean 12 hours) in acute stage and the next MRI was done within 3 days after the acute stage. 9 patients had right sided and 13 patients had left sided MCA territory infarct, the mean DWI-ASPECTS score was 4.3 (range 0–9). PVS was detected in 15 patients (mean score 4.1, range 0–10). Out of 22 patients 9 patients showed no evolution in infarct however in 13 patients evolution was from (ASPECTS mean score 3.95, range 0–9; mean infarct growth score 7.4, range 0–10). 7 patients devoid of PVS in initial MRI, did not exhibited evolution of infarction. Of 15 patients with PVS on initial MRI, 13 (87%) had infarct growth. Correlation between the evolution in infarct size and PVS score was observed (r = 0.86, P<0.001). Conclusion: PVS seen in infarcted territory is related to poor prognosis and this can be reliably used as a surrogate marker of oxygen extraction in penumbra. SWI can predict tissue at risk and can be a replacement for perfusion scan in clinical scenerio of acute ischaemic infarct.

Download Full-text