Synthesis, Characterization and Biological Evaluation of some Novel 1, 3 Oxazepine derivatives from Vanillin Schiff's Bases

2018 ◽  
Vol 11 (9) ◽  
pp. 4047
Author(s):  
Khudhayer J. Kadem ◽  
Murad G. Munahi
Keyword(s):  
Biological Evaluation ◽  
Schiff’S Bases ◽  
Schiff's Bases

Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff’s Bases of Sulphonamides

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Neeraj Kumar ◽  
Dhruti Bhatt ◽  
Chandra Shekhar Sharma ◽  
Hamendra Pratap Singh ◽  
Harshda Pandiya ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Biological Evaluation ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Bases ◽  
E Coli ◽  
Schiff's Bases ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A. clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

scholarly journals Synthesis, characterization and biological evaluation of Schiff’s bases derivatives as potent antibacterial agents

2017 ◽  
Vol 4 (5) ◽  
pp. 216
Author(s):  
Versha Parcha ◽  
Ankit Kumar ◽  
Babita Mahajan ◽  
Jaswinder Kaur
Keyword(s):  
Antibacterial Effect ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Schiff’S Bases ◽  
Zone Of Inhibition ◽  
Schiff's Bases ◽  
Almost All ◽  
Derivatives Of ◽  
Antibacterial Potential ◽  
Schiffs Bases

Objective: To design, synthesize and screen biologically newer Substituted Schiff bases by condensing substituted acid hydrazides with various benzaldehydes and explore their antimicrobial potential.Methods: Present study synthesis of various derivatives of Schiffs bases was carried out by: firstly converting substituted acids to acid hydrazides and then to Schiff's bases after condensation with substituted benzaldehyde. Synthesized compounds were characterised on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect against Salmonella typhimurium, Shigella sonnei, Staphylococcus aureus& Bacillus cereus.Results: From this study it could be observed that schiff’s bases 2-[( aminophenylhydrazinyldene o,m,dinitrobenzoyl] aniline (H) and compound 2-[( aminophenylzinyldene) p amino benzoyl] aniline (I) showed very good zone of inhibition against almost all strains tested for.Conclusions: So further attempts could be made to extend the series and explore their antibacterial potential to achieve hopeful goal.

scholarly journals Synthesis and biological evaluation of new aryl substituted Schiff’s bases

2017 ◽  
Vol 4 (6) ◽  
pp. 252
Author(s):  
Versha Parcha ◽  
Jaswinder Kaur
Keyword(s):  
Antimicrobial Agents ◽  
Acid Hydrazide ◽  
Structure Activity Relationship ◽  
Biological Evaluation ◽  
Activity Relationship ◽  
Spectral Studies ◽  
Schiff’S Bases ◽  
Structure Activity ◽  
Schiff's Bases ◽  
Good Potential

Objective: Chemical substances employed to treat various infections caused by various types of microorganism are termed as antimicrobials and natural chemical compounds produced by specific types of bacteria are termed as antibiotics. Unlimited use of antibiotics in humans and animals and in areas other than the treatment and prophylaxis of disease have resulted in a serious problem of drug resistance. Various attempts have been adopted to cope with the resistance problem and enhance the activity, or broaden the spectrum of drugs. Based on structure-activity relationship synthesis of new compounds has been one of the best approaches for better results. It has been demonstrated that Schiff base of some leading molecules and antibiotics possess good potential as more effective and safe drugs. Encouraged by reports on potential of Schiff’s bases as antimicrobial agents and to cope up with the current requirements of developing newer, safer and broad spectrum agents attempts were made to synthesize new Schiff’s bases.Methods: Our earlier in which structure activity relationship studies revealed that substitution by nitro and amino gp in Schiff’s base moiety resulted in the enhancement of activity. So further attempts were made to extend the series with incorporation of nitro and amino moiety by condensing o,m dinitro substituted acid hydrazide with various nitro/amino substituted benzaldehydes for increasing their antimicrobial potential.Results: Synthesized compounds were characterized on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect. All the synthesized derivatives were screened further for their antibacterial effect.Conclusions: Highest activity was observed in the derivative with nitro substitution in both the aryl rings.

Synthesis, Characterization and Biological Evaluation of some Novel 2-Substituted Aminothiazoles

2021 ◽  
pp. 3104-3110
Author(s):  
Suresh Kumar ◽  
Renu Saharan ◽  
Randhir Singh
Keyword(s):  
Escherichia Coli ◽  
Candida Albicans ◽  
Growth Inhibition ◽  
Bacterial Strain ◽  
Biological Evaluation ◽  
Bacterial Activity ◽  
Schiff’S Bases ◽  
Fungal Activity ◽  
Schiff's Bases ◽  
Anti Fungal

The synthesis of biologically active molecules carried out by using Aminothiazole nuclei and their various derivatives as precursors. In present work, Schiff's bases (27-36) were prepared by reacting amino group of thiazole moiety (26) with various aromatic aldehydes. The titled, novel 2-substituted aminothiazoles (37-46) were obtained by reaction of these Schiff's bases with benzil by providing excess amount of ammonium acetate (NH4OAc). Structure elucidation of all the newly synthesized compounds was carried out by employing elemental analysis, FT-IR, 1H NMR and Mass spectrometry. The newly synthesized novel 2-substituted-aminothiazoles were screened for their anti-bacterial activity against two gram +ve bacterial strains viz. Staphylococcus aureus and Bacillus subtilis and against a gram –ve bacterial strain viz. Escherichia coli and for anti-fungal activity against two fungal strains viz. Candida albicans and Aspergillus niger using cup plate method by using Norfloxacin and Fluconazole as standard drugs respectively. Cyto-toxic activity of the synthesized compounds was evaluated by determining the percentage growth inhibition of Daltonꞌs Lymphoma Ascites (DLA) cells and Erlichꞌs Ascites Carcinoma (EAC) cells by Tryphan Blue Dye Exclusion technique. Results of biological activity studies indicated that the newly synthesized 2-substituted aminothiazoles displayed good anti-bacterial activity against gram –ve bacterial strain Escherichia coli and anti-fungal activity against Candida albicans. Further, these compounds were found to show significant percent growth inhibition against DLA and EAC, cell-lines.

scholarly journals Synthesis and Biological Evaluation of Some Novel Schiff’s Bases from 1,2,4-Triazole

Molecules ◽  
2007 ◽  
Vol 12 (6) ◽  
pp. 1202-1209 ◽  
Author(s):  
Xiao-Xia Ye ◽  
Zhen-Fei Chen ◽  
An-Jiang Zhang ◽  
Li-Xue Zhang
Keyword(s):  
Biological Evaluation ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis, Characterization and Biological Evaluation of Some Novel Hydrazide Schiff’s Bases and Their Metal Complexes

2013 ◽  
Vol 25 (5) ◽  
pp. 2668-2672 ◽  
Author(s):  
Mazhar Hussain ◽  
Zahid Shafiq ◽  
Mian Hasnain Nawaz ◽  
Muhammad Aslam Shad ◽  
Haq Nawaz ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Biological Evaluation ◽  
Schiff’S Bases ◽  
Schiff's Bases
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